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Adipocyte differentiation from the inside out 总被引:8,自引:0,他引:8
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The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis 总被引:2,自引:0,他引:2 下载免费PDF全文
Kortum RL Costanzo DL Haferbier J Schreiner SJ Razidlo GL Wu MH Volle DJ Mori T Sakaue H Chaika NV Chaika OV Lewis RE 《Molecular and cellular biology》2005,25(17):7592-7604
Mitogen-activated protein kinase pathways are implicated in the regulation of cell differentiation, although their precise roles in many differentiation programs remain elusive. The Raf/MEK/extracellular signal-regulated kinase (ERK) kinase cascade has been proposed to both promote and inhibit adipogenesis. Here, we titrate expression of the molecular scaffold kinase suppressor of Ras 1 (KSR1) to regulate signaling through the Raf/MEK/ERK/p90 ribosomal S6 kinase (RSK) kinase cascade and show how it determines adipogenic potential. Deletion of KSR1 prevents adipogenesis in vitro, which can be rescued by introduction of low levels of KSR1. Appropriate levels of KSR1 coordinate ERK and RSK activation with C/EBPbeta synthesis leading to the phosphorylation and stabilization of C/EBPbeta at the precise moment it is required within the adipogenic program. Elevated levels of KSR1 expression, previously shown to enhance cell proliferation, promote high, sustained ERK activation that phosphorylates and inhibits peroxisome proliferator-activated receptor gamma, inhibiting adipogenesis. Titration of KSR1 expression reveals how a molecular scaffold can modulate the intensity and duration of signaling emanating from a single pathway to dictate cell fate. 相似文献
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Eguchi J Yan QW Schones DE Kamal M Hsu CH Zhang MQ Crawford GE Rosen ED 《Cell metabolism》2008,7(1):86-94
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The transcriptional basis of adipocyte development 总被引:1,自引:0,他引:1
Rosen ED 《Prostaglandins, leukotrienes, and essential fatty acids》2005,73(1):31-34
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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis 总被引:1,自引:0,他引:1 下载免费PDF全文
Shin S Wakabayashi N Misra V Biswal S Lee GH Agoston ES Yamamoto M Kensler TW 《Molecular and cellular biology》2007,27(20):7188-7197