HIV-1整合酶及其抑制剂的研究进展

HIV-1整合酶是由HIV病毒pol基因编码的分子量为32KD的蛋白质,是HIV病毒复制的必需酶之一,它催化病毒DNA整合入宿主染色体DNA。人类细胞中没有HIV 整合酶的类似物[1],理论上抑制整合酶对人体副作用很小。因此HIV-1整合酶成为继HIV-1蛋白酶,逆转录酶后治疗艾滋病的富有吸引力和合理的靶标。本文综述了HIV整合酶结构,抑制剂的研究以及以HIV-1 整和酶为靶点治疗AIDS方法的最新研究进展。     

Evaluation of different leguminous seeds as food sources for the bean bug Riptortus pedestris

This study was conducted to determine the effects of six different leguminous seeds (cowpea, white kidney bean, soybean cultivars Cheongja and Daepung, mung bean, and azuki bean) on the life history traits of the bean bug Riptortus pedestris (F.) (Hemiptera: Alydidae). The total developmental time from the first instar nymph to adult ranged from 18 to 25 d; R. pedestris fed with white kidney beans were the slowest to develop. In addition, bugs fed with white kidney beans had the highest mortality (93%) and the shortest longevity (18 d). R. pedestris fed with cowpeas, soybeans, or azuki beans had high reproductive success, with the highest egg hatching success recorded in bugs fed cowpeas. The results suggest that cowpea may be a beneficial food source for the development and reproduction of bean bugs.