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Etheridge KT Banik SS Armbruster BN Zhu Y Terns RM Terns MP Counter CM 《The Journal of biological chemistry》2002,277(27):24764-24770
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Alves D Li H Codrington R Orte A Ren X Klenerman D Balasubramanian S 《Nature chemical biology》2008,4(5):287-289
Human telomerase is a ribonucleoprotein that is minimally comprised of protein (hTERT) and RNA (hTR) components. We have applied single-molecule fluorescence two-color coincidence detection to characterize complex formation between fluorophore-labeled components in solution. By systematic labeling and in vitro assembly of hTERT, hTR and telomerase's DNA substrate, we have established that catalytically functional human telomerase comprises a stable hTERT:hTR:substrate interaction in a 1:1:1 absolute stoichiometry. 相似文献
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