Cassava: constraints to production and the transfer of biotechnology to African laboratories

Knowledge and technology transfer to African institutes is an important objective to help achieve the United Nations Millennium Development Goals. Plant biotechnology in particular enables innovative advances in agriculture and industry, offering new prospects to promote the integration and dissemination of improved crops and their derivatives from developing countries into local markets and the global economy. There is also the need to broaden our knowledge and understanding of cassava as a staple food crop. Cassava (Manihot esculenta Crantz) is a vital source of calories for approximately 500 million people living in developing countries. Unfortunately, it is subject to numerous biotic and abiotic stresses that impact on production, consumption, marketability and also local and country economics. To date, improvements to cassava have been led via conventional plant breeding programmes, but with advances in molecular-assisted breeding and plant biotechnology new tools are being developed to hasten the generation of improved farmer-preferred cultivars. In this review, we report on the current constraints to cassava production and knowledge acquisition in Africa, including a case study discussing the opportunities and challenges of a technology transfer programme established between the Mikocheni Agricultural Research Institute in Tanzania and Europe-based researchers. The establishment of cassava biotechnology platform(s) should promote research capabilities in African institutions and allow scientists autonomy to adapt cassava to suit local agro-ecosystems, ultimately serving to develop a sustainable biotechnology infrastructure in African countries.     

Using genomic approaches to unravel livestock (host)-tick-pathogen interactions

Ticks and tick-borne diseases are a major constraint on livestock farming in many developing countries, which has a huge impact on their economies. Genomic information is becoming more abundant for many of the species involved, which if exploited successfully could be used to develop new control strategies. Here, we review the genomic resources that are now available and discuss how this information is currently being harnessed or can be used in the future to explore the complex interplay that occurs between livestock hosts, tick vectors and tick-borne pathogens.     

Better Global Assessment of Worker Inequality: Comment on “The Employment Footprints of Nations”

This commentary responds to the previously published Journal of Industrial Ecology article “The Employment Footprints of Nations: Uncovering Master‐Servant Relationships” by Alsamawi and colleagues. Their article uses extended input‐output analysis to calculate employment and income footprints and, consequently, quantifies and provides an analysis of the average wages embodied in consumption of countries in comparison with the wages received by domestic workers. In effect, Alsamawi and colleagues show the extent of inequality in labor income, especially between developed and developing economies, traced throughout the global supply chains, but ignore the price differentials existing between countries in their discussion of the welfare implications of global trade on workers. This commentary contends the appropriateness of adjusting nominal compensation of workers to purchasing power parity (PPP) when undertaking global comparisons that pertain to well‐being and recalculates the employment footprints and income footprints of nations with PPP adjustment. The price adjustment in this work is intended to show a more accurate depiction of the disparity among workers of different nations when their labor incomes are deflated by the index price of consumption goods in their country. Using observations covering 189 countries and 14,839 sectors for the period 1990–2011, the results of the adjustment reveal that the ratio of domestic wages to foreign wages paid in support of a country's consumption (footprint wages) tends to be underestimated for labor‐exporting countries (developing economies with relatively cheaper consumption goods) and overestimated for labor‐importing countries (developed economies with more expensive consumption goods), thus demonstrating, generally, relatively less income inequality than previously exposed.     

Biotechnology: developing countries and globalization

Biotechnology in a globalizing economy involves the participation of all countries–industrialized, developing and least developed, in the interconnected web of trade liberalization in closed and open-market economies. The various geopolitical or geocultural regions show striking approaches to the application of biotechnologies for development and the safeguarding of intellectual property rights. The generally held view that developing countries are doomed to being marginalized in a globalizing economy is, seemingly, in need of revision.     

Ecologically-based strategies for conservation and development in the tropics

Tropical countries are endowed with a rich array of biotic and geophysical resources. Only in the past 30 years has the rate of their resource transformation been so rapid as to threaten the environment, largely because of the demands of a growing human population resulting from the demographic transition. While resource transformations have produced the goods and services necessary to meet the needs of the growing populations, they have also generated a variety of effects on the environment and the societies of these countries. The rapid pace of technological advances and social change seriously threaten the sustainability of natural assets and ecological processes in these countries, with global consequences. This threat is exacerbated (1) by inadequate capability in these tropical countries to manage degradations in natural resources and the environment arising from technological interventions affecting large-scale ecological processes; and (2) by the coincidence of down-turns in long-term cycles of unequal amplitudes, which concern elitism and administrations, dependency on fossil fuels for industrialisation and shifts in cultural periods, all of which threaten the global structure and continuity of prevailing social institutions, Both phenomena endanger the prospects for international investments in the transformation of natural resources and management of the environment for sustainable livelihoods, especially in developing countries. most tropical countries have developing economies, and have inadequate capacity to manage the impacts and trade-offs of technological insertions largely because of financial constraints, poor technical expertise and the international character of their economies. In spite of harsh socio-biological, technological and financial constraints, there is a pressing need for investing in human expertise in tropical countries because of their effects on the sustainability of global climate, resource and environmental heritage, cultural heritage and societal organisation. Assurance of this sustainability demands that investments in tropical countries must be founded on traditional knowledge, organisation and community participation; on comparative advantages in terms of resource endowments and technological skills; on strategies and actions promoting innovative futures; on the strengthening of institutional capacities for assessing impacts and trade-offs; on a universally-acceptable system for exchanging experiences about technological insertions with reference to spatial areas, levels of sophistication, assessment of impacts and standards; and on the attraction of various forms of international cooperation at professional, governmental and non-governmental levels, which has been recommended by the World Commission on Environment and Development (Bruntland Commission). This overall challenge for international development in the tropics amounts to advancing macro-ecological and-economic sciences of large-scale processes having local impacts, andvice versa, involving the dynamic interactions between culture and philosophy, politics, investment (economics), society, technology and environment at different spatial and temporal scales.     

International Cooperation for Metal Recycling From Waste Electrical and Electronic Equipment

This article addresses a market‐based management concept for waste electrical and electronic equipment (WEEE) known as the “best‐of‐two‐worlds” approach. The concept is based on the idea that recyclers in developing countries and emerging economies can cooperate with technologically advanced refineries in industrialized countries to facilitate efficient recovery of valuable metals, such as gold and palladium, from e‐waste. The article provides an overview of technical and environmental concerns underlying the concept and sheds light on the political framework, the waste‐related trade issues, and the resource economics that need to be considered for further decision making. Building on this synthesis, I conduct a qualitative assessment of sustainability impacts of the proposed concept by analyzing two scenarios and their associated risks. The analysis suggests that, under certain preconditions, the best‐of‐two‐worlds concept could yield significant improvements in terms of management of hazardous substances, resource efficiency, greenhouse gas emissions, income generation, and investments into social and environmental standards. Generally, two potential implementation scenarios were identified: Whereas under Scenario 1 only WEEE generated within developing countries and emerging economies is managed through the best‐of‐two‐worlds approach, Scenario 2 additionally incorporates WEEE imported from industrialized countries. Although both scenarios can yield a variety of benefits, Scenario 2 might cause a net flow of hazardous substances from industrialized countries into developing countries and emerging economies, thus leading to less beneficial sustainability impacts.     

The next steps for genomic medicine: challenges and opportunities for the developing world

This is a historical moment on the path to genomic medicine - the point at which theory is about to be translated into practice. We have previously described human genome variation studies taking place in Mexico, India, Thailand, and South Africa. Such investments into science and technology will enable these countries to embark on the path to the medical and health applications of genomics, and to benefit economically. Here we provide a perspective on the challenges and opportunities facing these and other countries in the developing world as they begin to harness genomics for the benefit of their populations.     

Globalization of biotechnology: The agglomeration of dispersed knowledge and information and its implications for the political economy of technology in developing countries

This study examines a contradictory development in the era of globalization wherein country-specific economic and socio-political institutional environment limits the global flow of technological knowledge and information, particularly in the biotechnology sector. International collaborations for developing new biotechnologies has increased significantly in recent years, but these have virtually bypassed firms in developing countries. The international flow of technologies tends to agglomerate in developed economies particularly in the US, where an appropriate mix of economic choices, social regulation and state action fostered institutional environments that facilitated the development and commercialization of biotechnologies. Moreover, with the heightening competition in the global economy, state and firms of developed economies have evolved into a relationship of close partnership. This shows that, far from being irrelevant, the state remains a political entity that structures the innovation system in order to promote the well-being of its firms. This calls for a re-thinking of the role of the state in technological and economic development, particularly among the developing economies.     

Biotechnology to improve health in developing countries -- a review

The growing health disparities between the developing and the developed world call for urgent action from the scientific community. Science and technology have in the past played a vital role in improving public health. Today, with the tremendous potential of genomics and other advances in the life sciences, the contribution of science to improve public health and reduce global health disparities is more pertinent than ever before. Yet the benefits of modern medicine still have not reached millions of people in developing countries. It is crucial to recognize that science and technology can be used very effectively in partnership with public health practices in developing countries and can enhance their efficacy. The fight to improve global health needs, in addition to effective public health measures, requires rapid and efficient diagnostic tools; new vaccines and drugs, efficient delivery methods and novel approaches to therapeutics; and low-cost restoration of water, soil and other natural resources. In 2002, the University of Toronto published a report on the "Top 10 Biotechnologies for Improving Health in Developing Countries". Here we review these new and emerging biotechnologies and explore how they can be used to support the goals of developing countries in improving health.     

Advances in plant biotechnology and its adoption in developing countries

Developing countries are already benefiting and should continue to benefit significantly from advances in plant biotechnology. Insect-protected cotton containing a natural insecticide protein from Bacillus thuringiensis (Bt cotton) is providing millions of farmers with increased yields, reduced insecticide costs and fewer health risks. Many other useful plant biotechnology products that can benefit poor farmers and consumers are in the research and development pipelines of institutions in developing countries, and should soon reach farmers' fields.     

Twenty-five years of international exchanges of plant genetic resources facilitated by the CGIAR genebanks: a case study on global interdependence

This article analyses 25 years of data about international movements of plant genetic resources for food and agriculture (PGRFA), facilitated by the gene banks hosted by seven centres of the Consultative Group on International Agricultural Research. It identifies trends in the movements of PGRFA for use in research and development, and describes the diversity of those resources transferred over time. The paper also presents data on the number of countries involved in the global exchanges, analyses their development status and describes their role as providers and/or recipients, providing a picture of the breadth of these global exchanges. We highlight that it is primarily developing and transition economies that have participated in the flows, and that the transferred germplasm has been largely used within their public agricultural research and development programmes. We conclude that, when provided the opportunity of facilitated access, countries will use a wide diversity of germplasm from many other countries, sub-regions and continents as inputs into their agricultural research and development programmes. We highlight the importance of enabling the continuation of the non-monetary benefits from international access to germplasm. We discuss the implications for the process of development and reform of the multilateral system of access and benefit sharing under International Treaty on Plant Genetic Resources for Food and Agriculture.     

Health biotechnology innovation on a global stage

With increasing globalization, infectious diseases are spreading faster than ever before, creating an urgent need for international collaboration. The rise of emerging economies has changed the traditional collaborative landscape and provided opportunities for more diverse models of collaboration involving developing countries, including North-South, South-South and North-South-South partnerships. Here, we discuss how developing countries can partner with other nations to address their shared health problems and to promote innovation. We look specifically at what drives collaborations and at the challenges that exist for them, and we propose actions that can strengthen these partnerships.     

Development and Dematerialization: An International Study

Economic development and growth depend on growing levels of resource use, and result in environmental impacts from large scale resource extraction and emissions of waste. In this study, we examine the resource dependency of economic activities over the past several decades for a set of countries comprising developing, emerging and mature industrialized economies. Rather than a single universal industrial development pathway, we find a diversity of economic dependencies on material use, made evident through cluster analysis. We conduct tests for relative and absolute decoupling of the economy from material use, and compare these with similar tests for decoupling from carbon emissions, both for single countries and country groupings using panel analysis. We show that, over the longer term, emerging and developing countries tend to have significantly larger material-economic coupling than mature industrialized economies (although this effect may be enhanced by trade patterns), but that the contrary is true for short-term coupling. Moreover, we demonstrate that absolute dematerialization limits economic growth rates, while the successful industrialization of developing countries inevitably requires a strong material component. Alternative development priorities are thus urgently needed both for mature and emerging economies: reducing absolute consumption levels for the former, and avoiding the trap of resource-intensive economic and human development for the latter.     

Supply management of high-value components with a credit constraint

Due to rapid increases in the automotive markets in emerging economies, leading car manufacturers rapidly expand their manufacturing capacity in countries such as China. A certain portion of key performance components however continue to be sourced from developed countries. We study such a manufacturer that imports high-value components from a developed country. There are two available transportation modes: a slow mode with low cost and long and stochastic lead time, and a fast mode with high cost and short and deterministic lead time. Moreover, the manufacturer is subject to a credit constraint that bounds both the in-warehouse inventory and the number of outstanding orders (because it needs to pay for the components in advance). Consequently, the cheapest hedge against demand and supply uncertainty??inventory??is only available to a limited extent and the decision maker must turn to using the fast transportation mode for a much larger share of the orders. We model the manufacturer??s ordering policy and study its performance using simulation. Our study shows the adverse effects that the credit limit has on the growth opportunities of such companies in developing countries that import high-value components or other goods from developed countries. We show that especially the reduction in lead time variability can substantially reduce these adverse effects. Realizing that this variability is primarily caused by the import customs procedures, governments in developing economies have a means to assist their local manufacturers.     

Food waste within food supply chains: quantification and potential for change to 2050

Food waste in the global food supply chain is reviewed in relation to the prospects for feeding a population of nine billion by 2050. Different definitions of food waste with respect to the complexities of food supply chains (FSCs)are discussed. An international literature review found a dearth of data on food waste and estimates varied widely; those for post-harvest losses of grain in developing countries might be overestimated. As much of the post-harvest loss data for developing countries was collected over 30 years ago, current global losses cannot be quantified. A significant gap exists in the understanding of the food waste implications of the rapid development of ‘BRIC’ economies. The limited data suggest that losses are much higher at the immediate post-harvest stages in developing countries and higher for perishable foods across industrialized and developing economies alike. For affluent economies, post-consumer food waste accounts for the greatest overall losses. To supplement the fragmentary picture and to gain a forward view, interviews were conducted with international FSC experts. The analyses highlighted the scale of the problem, the scope for improved system efficiencies and the challenges of affecting behavioural change to reduce post-consumer waste in affluent populations.     

From Norway to Novartis: cyclosporin from Tolypocladium inflatum in an open access bioprospecting regime

The Convention on Biological Diversity (CBD) introduces a new regime of source countries' national sovereignty over genetic resources, in which benefit sharing is a central factor. This article shows how Tolypocladium inflatum was collected in Norway in 1969 within an open access regime implying that there is no benefit sharing with the source country from Novartis' present sales of the derived medicines based on cyclosporin. We estimate source country's loss of benefits in comparison with present norms and expectations concerning bioprospecting. Two percent annual royalties would have been a reasonable claim in this case, and in 1997 this amounted to US$ 24.3 million. Such benefits could, for instance, have been targeted to conservation, scientific capacity building and health care. The study provides an indication of possible gains for source countries – countries with developed as well as developing economies – in a case of the finding of a blockbuster drug. Institutional prerequisites for benefit sharing are discussed, and the emphasis, which often is placed on the role of patents as the cause of lack of source country benefits, is in this case found to be misleading.     

The crisis seen from below,within, and against: from solidarity economy to food distribution cooperatives in Greece

Anthropological literature on crises and social and solidarity economies can benefit from integrated approaches that assess grassroots cooperatives formed during critical periods of capitalist recession. This article debates on why it is problematic to conceptualize the Greek crisis as exceptional and then examines the relationship between the solidarity economy and cooperatives and argues that the latter is a development of the former in the future plans of people struggling against the crisis being witnessed in Greece. It moreover makes a case for there being a need to pay more attention to the distribution sector. Its main aim is to point out how participants engaged in initiatives related to the solidarity economy tend to imagine that their activities are inspired by larger aims and claims than the immediate significance of their material actions. This is done by ethnographically analyzing organized social responses against crises through the rise of popular solidarity economies associated with distribution of food without middlemen.     

The Inequality Footprints of Nations: A Novel Approach to Quantitative Accounting of Income Inequality

In this study we use economic input-output analysis to calculate the inequality footprint of nations. An inequality footprint shows the link that each country''s domestic economic activity has to income distribution elsewhere in the world. To this end we use employment and household income accounts for 187 countries and an historical time series dating back to 1990. Our results show that in 2010, most developed countries had an inequality footprint that was higher than their within-country inequality, meaning that in order to support domestic lifestyles, these countries source imports from more unequal economies. Amongst exceptions are the United States and United Kingdom, which placed them on a par with many developing countries. Russia has a high within-country inequality nevertheless it has the lowest inequality footprint in the world, which is because of its trade connections with the Commonwealth of Independent States and Europe. Our findings show that the commodities that are inequality-intensive, such as electronic components, chemicals, fertilizers, minerals, and agricultural products often originate in developing countries characterized by high levels of inequality. Consumption of these commodities may implicate within-country inequality in both developing and developed countries.     

The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models

Fungal infections of the cornea are an important cause of blindness and visual impairment worldwide, with contact lens wear being the main risk factor in the USA and other industrialized countries, and traumatic injury being the main risk factor in developing countries. In this review, we highlight recent advances in the understanding of the host response to Aspergillus and Fusarium species in infected human corneal tissue and in mouse models of fungal keratitis.     

Global Integration and Subsistence Insecurity

Global integration heightens the cyclical crises of capitalism by incorporating the subsistence sectors of advanced and peripheral economies. World trends show a contraction in industrial production; the rise of unemployment, an increase in military spending and decline in social welfare, a reversal of capital flows from developing countries to developed economies, and a worldwide drop in real wages. The impact of these trends on communities in Mexico, Bolivia, and the United States where the author has done fieldwork is assessed in relation to current economic crises and the social movements that respond to them. The author shows that collective action to oppose the devastating effect on subsistence is more prevalent in marginal economies that are just beginning to experience the effect of capital penetration than in the industrial wastelands of developed countries. Theories of the crisis neglect those arenas where resistance and protest are most active: the urban barrios struggling for food and water, the rural laborers forced off of their land base, and the hunters and cultivators of the jungle. Luxemburg's thesis asserting the importance of the subsistence sector in capital accumulation acquires increasing significance at a time when those economies are threatened with extinction. Expanding the notion of subsistence production to include nonwage work allows us to theorize the significance of social reproduction in crisis conditions.