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《Journal of biomolecular techniques》2009,20(1):1-30
For more than two decades Genomics has grown as a discipline separately from Genetics. During this period the HGP was completed, other species were analyzed and the technology dramatically incremented. Methods for nucleic acids analysis now include the NexGen sequencing technologies for analysis of whole genomes and new DNA capture methods that allow sequencing of every human exon in a single sample. As a consequence, we are beginning to accrue the raw sequence of the whole genomes of multiple individuals and cell types. These methods are also being directed at finding specific disease alleles, and to characterize the full spectrum of variation in human populations as well as to study cancer. In combination these technologies provide unprecedented opportunity to study fundamental questions in biology. At long last the two disciplines of Genetics and Genomics are coming back together. 相似文献
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《Journal of fish biology》2002,61(SA):254-272
Costa, M. J. & Cabral, H. N. ( Instituto de Oceanografia, Faculdade de Ciências de Universidade de Lisboa, R. Ernesto de Vasconcelos, 1749-016 Lisboa, Portugal; Departamento de Zoologia e Antropologia, Faculdade de Ciências da Universidade de Lisboa, R. Ernesto de Vasconcelos, 1749-016 Lisboa, Portugal ), Almeida, P. R. ( Instituto de Oceanografia, Faculdade de Ciências de Universidade de Lisboa, R Ernesto de Vasconcelos, 1749-016 Lisboa, Portugal; Laboratório de Biologia da Conservação, Departamento de Biologia, Universidade de Évora, 7002-554 Évora, Portugal ), Costa, J. L., Chainho, P., Chaves, M. L., Prista, N., Vasconcelos, R. & Cabral, M. ( Instituto de Oceanografia, Faculdade de Ciêcias de Universidade de Lisboa, R. Ernesto de Vasconcelos, 1749-016 Lisboa, Portugal ). 相似文献