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1.
Lead, copper, zinc, and magnesium content in hair of children and young people with some neurological diseases 总被引:1,自引:0,他引:1
Lech T 《Biological trace element research》2002,85(2):111-126
The lead, copper, zinc, and magnesium levels of scalp hair taken from 153 children aged 1–15 yr and young people (16–18 yr)
with selected neurological disorders (hyperexcibility, loss of consciousness, and epileptiform convulsions of an unknown origin,
etc.), were measured using the atomic absorption spectrometry method and then compared with a control group of healthy children
(n=108). The research indicated significantly reduced mean levels of magnesium in the hair of children suffering from selected
neurological diseases (in children aged 11–15 yr of age, above 30%; up to 5 yr of age, nearly 30%; the differences were statistically
significant at p<0.05) and slightly decreased mean levels of copper (differences statistically significant at p<0.05, particularly in the 11 to 15-yr category). Differences in zinc levels in hair were inconsiderable (not statistically
significant in any age groups). The lead level in the hair of the above-mentioned group of children was exceeded in relation
to the control group (a statistically significant difference at p<0.05 for the total group). A more than twofold decrease in the mean value of the Mg/Pb ratio (and a nearly 30% decrease in
the value of the Mg/Zn ratio) in the hair of children suffering from neurological diseases suggests that the high toxicity
of lead accompanying, among other things, magnesium deficiencies might be a cause of the observed disorders in children. 相似文献
2.
X-ray fluorescence spectrometry and atomic absorption spectrometry were used in a quantitative study of zinc, copper, and
magnesium in 71 postmortal human hearts. Samples were obtained from individuals who had demonstrated no previous clinical
or subsequent pathological findings of myocardial infarction and from victims of a recent or an old infarction. A significant
difference (p<0.001) in the elemental levels was observed between the noninfarct and the recent infarct groups. The noninfarct group had
higher cardiac levels of all three elements. However, the difference in elemental concentrations between the noninfarct and
the old-infarct groups was not significant. Cardiac levels of zinc (p<0.001) and copper (p<0.01) were significantly greater in the old-infarct group than in the recent-infarct group. Magnesium levels were higher
in the recent-and-old-infarct group than in the recent infarct group (p<0.01). It is possible that the elements are redistributed during myocardial infarction, and that uptake of these elements
(from the serum pool) by the heart may be important in maintaining myocardial integrity and function. 相似文献
3.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
4.
Antonella Bertazzo Carlo Costa Monica Biasiolo Graziella Allegri Girolamo Cirrincione Giuseppe Presti 《Biological trace element research》1996,52(1):37-53
The Cu and Zn levels of both 607 men (1–85 y old) and 649 women (1–92 y old) were determined by atomic absorption spectrometry.
Sex does not influence Cu (14.89±0.89 μg/g and 15.26±0.79 μg/g hair for males and females, respectively) and Zn contents (200.97±9.68
μg/g for men and 209.81±9.49 μg/g hair for women). Age influences Cu and Zn concentrations, but only significantly in females:
Cu levels decrease over 60 y of age; whereas Zn levels increase significantly from age groups 2–5 to 20–40 years. Hair color
influences Cu concentrations in both males and females. In males, white hair containes less Cu than black hair; in females,
white hair's Cu levels are significantly lower than those of dark blond, red, light brown, and brown hair. There are no significant
differences in Zn concentrations with respect to different hair colors, in either males or females. 相似文献
5.
Orkide Donma Sacit Günbey Mehmet Ali Taş M. Metin Donma 《Biological trace element research》1990,24(1):39-47
Zinc, copper, and magnesium concentrations in hair were measured in groups of children varying in one condition—protein-energy
malnutrition, ricketts, thalassemia, malignancy, cardiac failure, or after prolonged infection and in healthy controls. As
compared with controls, copper and magnesium concentrations were low in all groups, whereas higher values were obtained for
hair zinc. These results showed that a generalized copper and magnesium deficiency were observed in the southeastern part
of Turkey. However, zinc deficiency couldn’t be detected as far as the hair zinc values were concerned, although all of the
subjects fell within the 50 percentile limits for their age-appropriate weights and heights. 相似文献
6.
Hair zinc and copper: Relationship to hair type and serum concentrations in children and adolescents
The zinc and copper serum and hair concentrations of 691 3-18-y-old girls and boys previously determined as a part of the
Multicentre Study of Atherosclerosis Precursors in Finnish Children and Adolescents were further analyzed in order to find
a possible association between these two zinc and copper indices. The influence of hair color and the diameter of individual
hair strands on hair concentrations were studied by the analysis of covariance. Hair color and serum zinc concentrations were
found to be associated with hair zinc concentrations in boys. Such an association was not found for zinc and copper concentrations
in girls. Hair vs serum concentrations in different age and hair color groups did not show however, a significant relationship
either in copper or in zinc concentrations. The subjects with very low or high serum zinc or copper concentrations did not
usually have extreme hair concentrations and vice versa. However, there were some subjects with low or high serum concentrations
associated with low or high hair concentrations. 相似文献
7.
To clarify the changes of mineral levels in different tissues of riboflavin-deficient rats, Wistar rats were separated into
three groups. One group was fed a diet ad libitum that was deficient in riboflavin. The other two were fed either the complete
diet that was weight-matched to the riboflavin-deficient group or fed a complete diet ad libitum. In riboflavin-deficient
rats, the hemoglobin concentration and riboflavin contents of blood, liver, and kidney were significantly decreased, compared
with weight-matched and ad libitum-fed controls. The mineral concentrations of tissues are summarized as follows: The iron
(Fe) concentration in the heart, liver, and spleen was decreased in the riboflavin-deficient group compared with the other
groups. Calcium (Ca) and magnesium (Mg) concentrations in tibia were decreased in the riboflavin-deficient group compared
with the other two groups. Copper (Cu) concentration was increased in the heart and liver when the riboflavin-deficient group
was compared with the other groups. Zinc (Zn) concentration was increased in tibia when the riboflavin-deficient group was
compared with the other groups. 相似文献
8.
The aim of this study was to determine the levels of tissue and blood zinc (Zn), copper (Cu), magnesium (Mg) in nitric oxide
(NO) synthase blockade-induced hypertension. A group of albino rats received a NO synthase inhibitor, N
G
-nitro-l-arginine-methyl ester (l-NAME, 60 mg/kg/d) in their drinking water for 21 d. l-NAME intake caused a progressive rise in this group’s resting mean arterial blood pressure compared to a control group (p<0.01). There were no differences between the groups with regard to tissue and blood levels of Zn or Cu; however, Mg concentrations
were significantly lower in the hypertensive rats’ erythrocytes (20.2% reduction from control levels), cerebral cortex (17.0%),
heart (9.1%), renal cortex (12%), renal medulla (16.7%), and in the tissues of the caval vein (23.7%), mesenteric artery (29.8%),
renal artery (18.4%), and renal vein (22.1%). There were no significant Mg concentration changes in the hypertensive group’s
plasma, cerebellum, liver, duodenum, or aortal tissue. These findings suggest that Mg depletion may play a role in the blood
pressure rise that occurs in the model of chronic NO synthase inhibition-induced hypertension. 相似文献
9.
Assessment of copper and zinc status in hair and urine of young women descendants of NIDDM parents 总被引:1,自引:0,他引:1
Satish K. Taneja Monika Mahajan Sumedha Gupta Kiran Pal Singh 《Biological trace element research》1998,62(3):255-264
The concentration of copper (Cu) and zinc (Zn) in hair and urine were studied in young nonpregnant healthy women whose both
parents were diagnosed for noninsulin-dependent diabetes mellitus (NIDDM descendants) and were compared with those of young
healthy nonpregnant females with no family history of NIDDM or hypertension (non-NIDDM descendants) and NIDDM patients. The
concentration of Zn in hair in NIDDM descendants was significantly higher than that of non-NIDDM descendants (p < 0.001) and insignificantly higher than that of NIDDM patients. The hair Cu concentrations in NIDDM descendant and patients
were significantly lower than that of non-NIDDM descendants (p < 0.001). Hyperzincuria was detected in some NIDDM patients and hypocuperuria in all NIDDM descendants and patients. The
data suggest that the young healthy NIDDM descendants possess high-Zn and low-Cu reserves in their bodies, and the observed
perturbation appears to be associated with Cu-Zn antagonism. 相似文献
10.
Kuru O Sentürk UK Gündüz F Aktekin B Aktekin MR 《Biological trace element research》2003,93(1-3):105-111
Trace element content of different tissues might be altered by both age and exercise training. We aimed to determine the effects
of a 1-yr swimming protocol (60 min/d, 5 day/wk) on tissue levels and the distribution of zinc (Zn), magnesium (Mg), and copper
(Cu) in aging rats. Three groups were formed: sedentary and trained old groups and a young control group. Tissue Zn, Mg, and
Cu concentrations were measured in the kidney, heart, liver, lungs, and gastrocnemius and soleus muscles. Kidney zinc concentration
significantly decreased in the sedentary old group compared to the young control group (p<0.01) and was significantly higher in the trained old group compared to the sedentary old group (p<0.01), whereas Zn levels in the soleus muscle significantly increased in the sedentary old group in comparison to young controls
(p<0.05). Tissue Mg concentrations remained unchanged. The sedentary old group exhibited a significant decrease in kidney Cu
concentration compared to the young control group (p<0.01). Although kidney Cu levels also decreased in trained old rats in comparison to young controls (p<0.05), they were significantly higher than in sedentary old rats (p<0.01). The decrease in kidney Zn and Cu content as a result of aging was partly prevented by long-term swimming exercise. 相似文献
11.
U. Carpentieri J. Myers C. W. Daeschner M. E. Haggard 《Biological trace element research》1988,16(2):165-176
The effects of simultaneous changes of calcium, magnesium, iron, copper, and zinc concentrations were evaluated in normal
human T and B lymphocytes, cultured in cation-depleted media. Optimal concentrations for thymidine incorporation (TI) in both
cell populations were Fe and Zn 15 μM and Cu 5 μM; for t cells Ca 2 mM and Mg 4 mM; for B cells Ca 4 mM and Mg 6 mM. TI decreased with increasing molarity of cations and the decrease was particularly apparent with Cu. Minimal amounts of
Ca and Mg (0.5 mM) were necessary for growth, even in presence of optimal concentrations of Fe, Cu, and Zn. Fe and Cu showed synergistic stimulatory
effects at low concentrations and synergistic inhibitory effects at high concentrations. Antagonism between Fe and Zn, Cu
and Zn, and Ca and Zn was also demonstrated. CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with
ConA stimulation in presence of Zn or Fe. The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and
Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8
positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca
and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth
of B cells higher than T cells. 相似文献
12.
Postpartum scalp hair samples from 82 term-pregnancy mother/neonate pairs were analyzed for their concentration of zinc (Zn),
copper (Cu), cadmium (Cd), and lead (Pb), using inductively coupled plasma-mass spectrometry. Maternal and neonatal Zn concentrations
had geometric means (and 99% confidence intervals) of 122.5 μg/g (117.9–131.5 μg/g) and 146.9 μg (141.5–156.7 μg/g) respectively.
Corresponding Cu values were 18.4 μg/g (17.6–23.8 μg/g) and 6.7 μg/g (6.3–7.6 μg/g). Those of Cd were 0.49 μg/g (0.47–0.69
μg/g) in the mothers and 0.57 μg/g (0.55–0.86 μg/g) in the neonates. For Pb, they were 7.95 μg/g (7.60–9.32 μg/g) and 4.56
μg/g (4.39–5.56 μg/g). Cigaret smoking, despite its relatively low prevalence (19.5%), was associated with lower Zn and higher
Cd and Pb concentrations and in lower Zn/Cd and Zn/Pb molar concentration ratios. Smoking also altered interelemental relationships,
particularly those of Zn with Cd and Pb and those between Cd and Pb. Smoking frequency appeared to show negative dose-response
effects on maternal and neonatal Zn concentrations, Zn/Pb molar concentration ratios, and birth weight. Mothers with a history
of oral contraceptive (OC) usage had significantly higher Cu concentrations and lower Zn/Cu molar concentration ratios than
nonusers, with the highest Cu concentrations and lowest Zn/Cu values being associated with third-generation OCs. No similar
effects were elicited in the respective neonatal Cu concentrations. Neither alcohol consumption nor prenatal supplementation
with iron and/or folic acid had discernible effects on the maternal or neonatal elemental concentrations. The data from this
study suggest that in a given population of term-pregnancy mothers and neonates, significant interindividual variations in
hair trace element concentrations can occur, irrespective of commonality of general environment, and that lifestyle factors,
including cigaret smoking and OC usage history, can be significant contributory factors to such variations. The data are discussed
in relation to the effects of smoking-associated exposure to Cd and Pb exposure on Zn availability for placental transfer,
as well as on the quantitative maternal Zn supply levels to the fetus resulting from the known tendency of smokers to have
lower dietary intakes of Zn. The higher Cu concentrations in OC users are discussed in relation to altered Cu metabolism,
characterized by increased synthesis of the Cu-binding protein, ceruloplasmin, as an acute-phase antioxidant response to altered
lipid profile and increased lipid oxidation. 相似文献
13.
Jana Kadrabová Alexander Madarič Zuzana Kováčiková Emil Ginter 《Biological trace element research》1995,50(1):13-24
Plasma zinc (Zn), copper (Cu), and magnesium (Mg) concentrations, copper/zinc ratio, and selenium (Se) status were studied
in 44 vegetarians (22 males and 22 females) and their age- and sex-matched nonvegetarians in the Bratislava region (Slovakia).
Vegetarians had statistically significant lower levels of plasma Zn and Cu than nonvegetarians, which may be the result of
lower bioavailability of Zn and Cu from this type of diet. No differences in plasma Mg levels were found between vegetarians
and nonvegetarians.
Se status, as expressed by plasma and erythrocyte concentrations and plasma and erythrocyte glutathione peroxidase activities
(GPx), was significantly lower in vegetarians when compared to nonvegetarians. In the series as a whole, there were significantly
higher correlations between plasma and erythrocyte Se concentrations and between plasma and erythrocyte GPx activities. Significant
positive correlations were also found between plasma Se concentrations and erythrocyte GPx activities, and between erythrocyte
Se concentrations and erythrocyte GPx activities.
A vegetarian diet does not provide a sufficient supply of essential antioxidant trace elements, like Zn, Cu, and especially
Se. Se supplementation should be recommended to this risk group of the population. 相似文献
14.
Abdellatif Chakar Ridha Mokni Philip A. Walravens Philippe Chappuis Fanny Bleiberg-Daniel Jean-Louis Mahu Daniel Lemonnier 《Biological trace element research》1993,38(1):97-106
Plasma zinc, copper, and parameters of growth were measured in a group of 116 French preschool children, 2–5 yr-old from low-income
households. Participants were selected on the basis of Z-scores of weight for height (WHZ) and height for age (HAZ). Zinc
and copper concentrations of children with growth impairment (GI), defined by a WHZ and/or HAZ< −1 Z-score, were compared
to those of age, sex, and ethnic origin matched controls (WHZ and HAZ >−1 Z-score). Mean (±SD) plasma zinc concentration was
12.58±1.84 μmol/L in the GI group, and 13.27±1.98 μmol/L in the controls. The difference of the means of paired samples was
0.69±2.34, and by pairedt-test the significance reachedp=0.028. This effect was primarily a result of the weight retarded group (WHZ <−1 Z-score,p<0.009) and to the girls (p<0.05). There were no significant differences in plasma copper concentrations between groups. These results suggest the presence
of marginal zinc deficiency in French preschool children with low weight for height Z-scores. 相似文献
15.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献
16.
The use of hair and bone as media in evaluation of lead exposure was investigated in this study. For 12–16 wk rats were given
tap water containing lead acetate in the following concentrations: 41.7 mg Pb/L, 83.3 mg Pb/L, and 166.6 mg Pb/L. The animals
were sacrificed every 4 wk and their tibia bones and hair were collected for determination of lead content. In control animals,
the lead level amounted to 1.2 μg/g (range 0.8–1.3 μg/g) and 0.7 μg/g (range 0.4–2.0 μg/g) in bone and hair, respectively.
In the treated rats the accumulation of lead in bone and hair occurred in a dose-dependent manner. A positive corelation (r=0.876) was established between the lead levels in bone and hair of the rats. The regression equation was as follows: μg Pb/g
bone=0.842×μg Pb/g hair+1.868. After discontinuation of exposure, a significant decrease in the lead content in bone and hair
was noticed. About 9 wk after cessation of treatment, the lead content in hair declined to the pre-exposure level, but 64%
of the maximal lead concentration did remain in bone. The results of this study indicate that during a continuous exposure
the lead level in hair reflects its content in bone. Such phenomena did not occur during the postexposure period. 相似文献
17.
Lino Piccinini Paola Borella Annalisa Bargellini Cristina Incerti Medici Alessandra Zoboli 《Biological trace element research》1996,51(1):23-30
The purpose of our study was to investigate the relationship between plasma and hair levels of Se, Zn, and Cu, and cancer.
We selected a total of 66 patients affected by either breast (38) or lung (28) cancer. They entered into the study at the
onset of disease, and before any chemical or radiotherapy. Controls were randomly selected among healthy people and were matched
for sex, age, smoking habits, and residence. In the group of breast cancer, a significant decrease in hair Se was found compared
to controls (p<0.01), whereas plasma Se was only slightly decreased. No difference between cases and controls was detected in both hair
and plasma levels of Zn and Cu. Subjects who developed lung cancer were significantly lower in hair Zn (p<0.05) and Cu (p<0.01) than controls, whereas there was no difference with regard to Se. In addition, plasma Cu of these patients was increased
as compared to controls. 相似文献
18.
Djukić-Cosić D Ninković M Malicević Z Plamenac-Bulat Z Matović V 《Biological trace element research》2006,114(1-3):281-291
In this report, we present the results of our investigations on the effect of Mg pretreatment on Cd and bioelements (Cu and
Zn) contents in kidney of mice exposed to acute and subacute Cd intoxication. Acute intoxication was performed on male Swiss
mice given a single oral dose of 20 mg Cd/kg body weight and mice given the same dose of Cd but pretreated with 40 mg Mg/kg
body weight. For subacute intoxication one group of mice was given 10 mg Cd/kg body weight every day, for 2 wk, and the other
one received the same dose of Cd after oral Mg intake of 20 mg/kg body weight. Cd, Cu, and Zn content was determined in kidney
by atomic absorption spectrophotometry. In acute Cd intoxication, Mg pretreatment resulted in significant decrease of Cd in
kidney after 4 and 6 h, compared with animals given only Cd. Under the condition of subacute Cd intoxication, Mg supplementation
reduced Cd kidney content after 2 wk for about 30%, compared with animals treated with Cd only. The effect of Mg on Cu and
Zn kidney content was also beneficial. 相似文献
19.
Trace elements are known to have a key role in myocardial metabolism. The accumulation (cobalt, arsenic, copper) or deficiency
(selenium, zinc) of trace elements may be responsible for idiopathic dilated cardiomyopathy. We investigated the trace element
concentrations (Cu, Zn, Mg) in sera from patients with dilated cardiomyopathy by atomic absorption spectrophotometry. We observed
that patients with dilated cardiomyopathies have higher copper and lower zinc concentrations in serum than healthy controls.
The magnesium concentrations of patients did not differ significantly from that of control subjects. 相似文献
20.
The concentrations of zinc and copper in gastric juice of humans who had widely varying dietary zinc intake were evaluated.
In order to compare this with zinc and copper levels of normal dietary individuals, we also determined the zinc and copper
levels in healthy individuals' plasma and in cancer patient's natural tissue, all of whom had normal diets. The correlation
coefficients between zinc and copper were 0.71, 0.45, and 0.55, respectively, in gastric juice, plasma, and tissue of normal
dietary subjects. Such correlation changed and was destroyed when there was a high zinc level in gastric juice. When gastric
juice zinc level changed from mean value 16.8 μmol/L to 262.5 μmol/L, the correlation coefficient varied from 0.71 to −0.04,
and the copper level also varied from mean value 8.96 μmol/L to 4.89 μmol/L. These findings probably give the evidence to
suggest that a high zinc level will restrain the copper level and break the balance of the human body's zinc and copper metabolism. 相似文献