The oxo/peroxo debate: a nonheme iron perspective

The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.     

Outdoor thermal comfort characteristics in the hot and humid region from a gender perspective

Thermal comfort is a subjective psychological perception of people based also on physiological thermoregulation mechanisms when the human body is exposed to a combination of various environmental factors including air temperature, air humidity, wind speed, and radiation conditions. Due to the importance of gender in the issue of outdoor thermal comfort, this study compared and examined the thermal comfort-related differences between male and female subjects using previous data from Taiwanese questionnaire survey. Compared with males, the results indicated that females in Taiwan are less tolerant to hot conditions and intensely protect themselves from sun exposure. Our analytical results are inconsistent with the findings of previous physiological studies concerning thermal comfort indicating that females have superior thermal physiological tolerance than males. On the contrary, our findings can be interpreted on psychological level. Environmental behavioral learning theory was adopted in this study to elucidate this observed contradiction between the autonomic thermal physiological and psychological–behavioral aspects. Women might desire for a light skin tone through social learning processes, such as observation and education, which is subsequently reflected in their psychological perceptions (fears of heat and sun exposure) and behavioral adjustments (carrying umbrellas or searching for shade). Hence, these unique psychological and behavioral phenomena cannot be directly explained by autonomic physiological thermoregulation mechanisms. The findings of this study serve as a reference for designing spaces that accommodates gender-specific thermal comfort characteristics. Recommendations include providing additional suitable sheltered areas in open areas, such as city squares and parks, to satisfy the thermal comfort needs of females.     

Lessons from the human embryo debate

Britain has given the green light for research on stem cells derived from human embryos. Nigel Williams reports on the discussion ahead of this controversial decision.     

The accountant as triage master: an economist's perspective on voluntary euthanasia and the value of life debate

The author, an economist, rebuts the contention that human life cannot and should not be economically evaluated and argues that such evaluations are made implicitly and inconsistently, resulting in a reduction of human welfare. He presents an economic framework for the analysis of costs and benefits in which the focal point, as in most value systems, is the tradeoff between life and quality of life. Therefore, as the quality of life decreases, society's efforts to preserve life should decrease. If the valuation of life includes self evaluation, then there should be less effort to preserve the life of an individual who wishes to die. Richardson concludes that voluntary euthanasia is a limiting case in which society accepts the individual's valuation of life.     

The Indian stratification debate: A discursive exposition of problems and issues in the analysis of class,caste and gender

Conclusion In order to analyze the interrelationships between class, caste and gender, it is essential to analyze the relationship between anthropology and political economy. In non-Marxist anthropology, elitism, cultural relativism, and evolutionism are still influential. The tension in Barrington Moore between a materialist and idealist view of the class/caste relationship is finally resolved in favor of idealism. Moore's idealism sharply contrasts with much contemporary work on peasant struggles in India, in which the peasants are no longer denied access to the historical stage. This shift in focus to the oppressed is only partially reflected in the field of gender, caste and class. While some work on gender, caste and class is both evolutionary and elitist in focus, the emphasis is now changing, and giving way to a more critical historical materialist perspective in which the historical subject is not permanently and inexorably relegated to the wings. Kate Currie is a Professor in the Department of Sociology, Lancaster University, Lancaster.

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On the role of autophagy in human diseases: a gender perspective

Cytopathological features of cells from males and females, i.e. XX and XY isolated cells, have been demonstrated to represent a key variable in the mechanism underlying gender disparity in human diseases. Major insights came from the studies of gender differences in cell fate, e.g. in apoptotic susceptibility. We report here some novel insights recently emerged from literature that are referred as to a cytoprotection mechanism by which cells recycle cytoplasm and dispose of excess or defective organelles, i.e. autophagy. Autophagy and related genes have first been identified in yeast. Orthologue genes have subsequently been found in other organisms, including human beings. This stimulated the research in the field and, thanks to the use of molecular genetics and cell biology in different model systems, autophagy gained the attention of several research groups operating to analyse the pathogenetic mechanisms of human diseases. It remains unclear, however, whether autophagy can exert a protective effect or instead contribute to the pathogenesis of important human diseases. On the basis of the growing importance of sex/gender as key determinant of human pathology and of the known differences between males and females in the onset, progression, drug susceptibility and outcome of a plethora of diseases, the idea that autophagy could represent key and critical factor should be taken into account. In the review, we summarize our current knowledge about the role of autophagy in some paradigmatic human diseases (cancer, neurodegenerative, autoimmune, cardiovascular) and the role of 'cell sex' differences in this context.     

The Icelandic genome debate

Three of the central issues in contemporary debates about the commodification of the human body are those of property, ownership, and access. This article uses the case of the central medical database on Icelanders to discuss contesting claims about the ownership of the human genome, with respect to the rapid development of biotechnology, human genome projects and DNA collections. We emphasize the contrast between commercial and communitarian perspectives and to illustrate our argument we explore debates about the Icelandic database. These debates have been intense, focusing on a range of issues, including ethics, academic freedom, public health and, last but not least, the control and ownership of medical records, genetic information and genealogical data. This article should be seen primarily as an anthropological commentary on ongoing developments.     

The animal cultures debate

Recent interest in animal cultures has been fuelled by high-profile reports of intra- and interpopulation differences in the behavioural repertoires of primates and cetaceans, consistent with the existence of socially learned traditions. Several studies have mapped spatial differences in behaviour, revealing a mosaic of behavioural phenotypes within species. The dominant current approach attempts to determine whether this is cultural variation by excluding asocial learning, ecological or genetic factors. However, claims of animal cultures remain controversial because such comparisons are subject to weaknesses; thus, new approaches to isolating the influence of culture on behaviour are required. Here we suggest that, rather than attributing behaviour to explanatory categories, researchers would often be better advised to partition variance in behaviour to alternative sources.