共查询到20条相似文献,搜索用时 15 毫秒
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Different regions of the estrogen receptor are required for synergistic action with the glucocorticoid and progesterone receptors. 总被引:1,自引:0,他引:1 下载免费PDF全文
Estrogen and progesterone or estrogen and glucocorticoid receptors functionally cooperate in gene activation if their cognate binding sites are close to one another. These interactions have been described as synergism of action of the steroid receptors. The mechanism by which synergism is achieved is not clear, although protein-protein interaction of the receptors is one of the favorite models. In transfection experiments with receptor expression vectors and a reporter gene containing estrogen and progesterone-glucocorticoid receptor binding sites, we have examined the effects that different portions of the various receptors have on synergism. N-terminal domains of the chicken progesterone and human glucocorticoid receptors, when deleted, abolished the synergistic action of these receptors with the estrogen receptor. Deletion of the carboxy-terminal amino acids 341 to 595 of the estrogen receptor produced a mutant receptor that could not trans-activate on its own. This mutant receptor did not affect the action of the glucocorticoid receptor but functioned synergistically with the progesterone receptor. We therefore conclude that the synergistic action of the receptors for estrogen and progesterone is mechanistically different from the synergistic action of the receptors for estrogen and glucocorticoid. 相似文献
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Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix 下载免费PDF全文
Yang L Guerrero J Hong H DeFranco DB Stallcup MR 《Molecular biology of the cell》2000,11(6):2007-2018
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A Cellular Repressor of E1A-Stimulated Genes That Inhibits Activation by E2F 总被引:15,自引:1,他引:14 下载免费PDF全文
Elizabeth Veal Michael Eisenstein Zian H. Tseng Grace Gill 《Molecular and cellular biology》1998,18(9):5032-5041
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Cassuto H Kochan K Chakravarty K Cohen H Blum B Olswang Y Hakimi P Xu C Massillon D Hanson RW Reshef L 《The Journal of biological chemistry》2005,280(40):33873-33884