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Ohbayashi T Shimada M Nakadai T Wada T Handa H Tamura T 《Nucleic acids research》2003,31(8):2127-2133
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Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes
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Kopytova DV Krasnov AN Kopantceva MR Nabirochkina EN Nikolenko JV Maksimenko O Kurshakova MM Lebedeva LA Yerokhin MM Simonova OB Korochkin LI Tora L Georgiev PG Georgieva SG 《Molecular and cellular biology》2006,26(20):7492-7505
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Analysis of the chicken TBP-like protein(tlp) gene: evidence for a striking conservation of vertebrate TLPs and for a close relationship between vertebrate tbp and tlp genes. 总被引:3,自引:0,他引:3
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M Shimada T Ohbayashi M Ishida T Nakadai Y Makino T Aoki T Kawata T Suzuki Y Matsuda T Tamura 《Nucleic acids research》1999,27(15):3146-3152
TLP (TBP-like protein), which is a new protein dis-covered by us, has a structure similar to that of the C-terminal conserved domain (CCD) of TBP, although its function has not yet been elucidated. We isolated cDNA and genomic DNA that encode chicken TLP (cTLP) and determined their structures. The predicted amino acid sequence of cTLP was 98 and 91% identical to that of its mammalian and Xenopus counterparts, respectively, and its translation product was ubiquitously observed in chicken tissues. FISH detection showed that chicken tlp and tbp genes were mapped at 3q2.6-2.8 and 3q2.4-2.6 of the same chromosome, respectively. Genome analysis revealed that the chicken tlp gene was spliced with five introns. Interestingly, the vertebrate tbp genes were also found to be split by five introns when we focused on the CCDs, and their splicing points were similar to those of tlp. On the contrary, another TBP-resembling gene of Drosophila, trf1, is split by only one intron, as is the Drosophila 's tbp gene. These results support our earlier assumption that vertebrate TLPs did not directly descend from Drosophila TRF1. On the basis of these results together with phylogenetical exam-ination, we speculate that tlp diverged from an ancestral tbp gene through a process of gene duplication and point mutations. 相似文献
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Chong JA Moran MM Teichmann M Kaczmarek JS Roeder R Clapham DE 《Molecular and cellular biology》2005,25(7):2632-2643
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