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Leask A 《Journal of cell communication and signaling》2010,4(3):157-158
There is no treatment for fibrotic disease is a significant cause of mortality. CCN2 Members of the CCN family of matricellular
proteins have a characteristic four domain structure. CCN2 (connective tissue growth factor) is believed to play an essential
role in fibrogenesis. In a recent paper, data are provided that CCN5 (wisp2), which lacks the carboxy-terminal heparin-binding
domain shared by the other CCN proteins, may act as a dominant-negative protein to suppress CCN2-mediated fibrogenesis. These
data are consistent with the notion that different CCN proteins may enhance or suppress each other’s action and also suggest
that CCN5, may be used as a novel anti-fibrotic therapy. 相似文献
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Leask A 《Journal of cell communication and signaling》2011,5(1):67-68
There is no treatment for the autoimmune disease scleroderma (systemic sclerosis, SSc), a multisystem disorder characterized by vascular damage and fibrosis. In particular, SSc can severely affect the lung, resulting in pulmonary arterial hypertension and fibrosis. Smoking is well-known to affect pulmonary health, and a recent report (Hudson et al., Arthritis Rheum, in press Oct 8) provides convincing evidence that stopping smoking improves disease outcome in SSc patients. This commentary discusses this recent publication which suggests that physicians should encourage SSc patients to stop smoking immediately. 相似文献
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The lack of species inventory data for most marine habitats currently hampers the objective management of marine biodiversity.
There is thus a clear need to find reliable indicator taxa that can be targeted in marine conservation studies, providing
cost-effective data for planning and monitoring. Using the rocky shores of the Solitary Islands Marine Park, NSW, Australia,
as a model, I evaluated macroinvertebrates and determined which taxa (i) best reflected ecological patterns of the broader
intertidal community; and (ii) were able to accurately predict species richness of assemblages at the headland scale. Both
molluscs and crustaceans showed high levels of correlation with overall species richness. However, molluscs, and in particular
prosobranchs, most closely reflected patterns in the community data and provided the most accurate predictions of species
richness at the scale of the headland. The potential time savings of using molluscs in rapid assessments are considerable
and relate to reductions in field time (by up to 40%) as well as the reduced need to invest time developing extensive taxonomic
knowledge of other invertebrate groups. Molluscs are widespread and easily sampled, with stable taxonomy and well-known ecology
relative to other marine invertebrate taxa. Their use as surrogates of biodiversity shows great potential for future marine
conservation studies. 相似文献
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Tom McSorley 《CMAJ》2013,185(12):1068-1069
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《Current biology : CB》2021,31(15):R950-R952
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Mitochondrial DNA polymorphisms as risk factors for Parkinson’s disease and Parkinson’s disease dementia 总被引:8,自引:0,他引:8
Autere J Moilanen JS Finnilä S Soininen H Mannermaa A Hartikainen P Hallikainen M Majamaa K 《Human genetics》2004,115(1):29-35
The activity of complex I of the mitochondrial respiratory chain has been found to be decreased in patients with Parkinsons disease (PD), but no mutations have been identified in genes encoding complex I subunits. Recent studies have suggested that polymorphisms in mitochondrial DNA (mtDNA)-encoded complex I genes (MTND) modify susceptibility to PD. We hypothesize that the risk of PD is conveyed by the total number of nonsynonymous substitutions in the MTND genes in various mtDNA lineages rather than by single mutations. To test this possibility, we determined the number of nonsynonymous substitutions of the seven MTND genes from 183 Finns. The differences in the total number of nonsynonymous substitutions and the nonsynonymous to synonymous substitution rate ratio (Ka/Ks) of MTND genes between the European mtDNA haplogroup clusters (HV, JT, KU, IWX) were analysed by using a statistical approach. Patients with PD (n=238) underwent clinical examination together with mtDNA haplogroup analysis and the clinical features between patient groups defined by the number of nonsynonymous substitutions were compared. Our analysis revealed that the haplogroup clusters HV and KU had a lower average number of amino acid replacements and a lower Ka/Ks ratio in the MTND genes than clusters JT and IWX. Supercluster JTIWX with the highest number of amino acid replacements was more frequent among PD patients and even more frequent among patients with PD who developed dementia. Our results suggest that a relative excess of nonsynonymous mutations in MTND genes in supercluster JTWIX is associated with an increased risk of PD and the disease progression to dementia. 相似文献
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《Current biology : CB》2022,32(22):4890-4899.e4
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Wood WG Igbavboa U Eckert GP Johnson-Anuna LN Müller WE 《Molecular neurobiology》2005,31(1-3):185-192
There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that elevated cholesterol levels are a risk factor for Alzheimer's disease. If elevated cholesterol is a risk factor for Alzheimer's disease, then it would be expected that patients with Alzheimer's disease would have elevated serum and brain cholesterol levels. Studies were reviewed that have examined cholesterol levels in Alzheimer's patients and control subjects, including prospective studies, and based on that review, the conclusion is reached that the majority of studies do not support elevated cholesterol levels in serum and brain as a risk factor for Alzheimer's disease. Alternative hypotheses are discussed, including cholesterol domains and subgroups of individuals with hypercholesteremia. 相似文献
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《Cell》2023,186(4):690-692
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