共查询到18条相似文献,搜索用时 93 毫秒
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黄原胶发酵培养基优化研究 总被引:3,自引:0,他引:3
分别用单因素法和正交试验法对野油菜黄单胞菌J-12的发酵培养基成分进行研究。得到的最优培养基配方为:4%玉米淀粉、0.3%鱼粉、0.3%豆饼粉、0.3%CaCO_3、0.5%KH_2PO_4、0.25%MgSO_4、0.025%FeSO_4、0.025%柠檬酸,接种量5%。在消前pH7.2~7.5,发酵温度28℃,摇床转速180r/min,发酵时间72h的实验条件下,发酵液粘度为8740mPa·s,采用酒精直接沉淀法提取黄原胶的产率达2.91%,产品的丙酮酸含量3.32%。 相似文献
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XCCNA-92发酵生产黄原胶的适宜条件是:好氧,发酵温度为30℃,培养基起始pH为7.0,接种量6%,发酵周期60h。利用最佳培养基配方,在30℃,150r/min条件下发酵72h,工业级黄原胶产量达40.84g/L,发酵液粘度86000cp,丙酮含量4.1%,碳源转化率达68.1%。 相似文献
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黄单胞菌R5产黄原胶的工艺条件研究 总被引:2,自引:0,他引:2
本文报道了黄单胞菌(Xanthomonascampestris)XC—82·5的诱导株R5发酵生产黄原胶的最适工艺条件。探讨了培养基中不同的碳源、发酵溶氧状况、发酵温度、pH值、菌龄对产胶水平的影响,向时发现:以菜油替代PPE作消泡剂有其独特的优越性;H2O2水不能改善溶氧水平。 相似文献
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槐豆胶与黄原胶的协效性研究 总被引:7,自引:0,他引:7
对槐豆胶与黄原胶的协效性进行了研究,结果表明,槐豆胶和黄原胶有较高的协效性,其最佳配比(重量比)为2:8;当混合液浓度达到0.5%-0.6%时形成凝胶,因此槐豆胶可作为黄原胶的增稠剂和凝胶剂。 相似文献
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实验研究了放置温度、时间、冻融、pH、盐以及柠檬酸对黄原胶和假酸浆子胶混胶黏度的影响.结果表明:黄原胶和假酸浆子胶有协效性,当假酸浆子胶与黄原胶的质量比15:85时,二者的协同增效性最高,胶溶液为非牛顿型流体,且变化满足Herschel-Bulkley方程.温度、时间对混胶有一定的影响.进一步对其研究表明:冻融、pH、盐以及柠檬酸都对其影响较小. 相似文献
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Xanthan gum, a microbial desiccation-resistant polysaccharide prepared commercially by aerobic submerged fermentation from
Xanthomonas campestris, has been successfully used as a solidifying agent for plant tissue culture media. Its suitability as a substitute to agar
was demonstrated for in vitro seed germination, caulogenesis and rhizogenesis of Albizzia lebbeck, androgenesis in anther cultures of Datura innoxia, and somatic embryogenesis in callus cultures of Calliandra tweedii. Culture media used for eliciting these morphogenic responses were gelled with either 1% xanthan gum or 0.9% agar. Xanthan
gum, like agar, supported all these responses. 相似文献
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The objective of present investigation was to develop venlafaxine hydrochloride-layered tablets for obtaining sustained drug
release. The tablets containing venlafaxine hydrochloride 150 mg were prepared by wet granulation technique using xanthan
gum in the middle layer and barrier layers. The granules and tablets were characterized. The in vitro drug dissolution study was conducted in distilled water. The tablets containing two lower strengths were also developed using
the same percentage composition of the middle layer. Kinetics of drug release was studied. The optimized batches were tested
for water uptake study. Radar diagrams are provided to compare the performance of formulated tablets with the reference products,
Effexor XR capsules. The granules ready for compression exhibited good flow and compressibility when xanthan gum was used
in the intragranular and extragranular fractions. Monolayer tablets failed to give the release pattern similar to that of
the reference product. The drug release was best explained by Weibull model. A unified Weibull equation was evolved to express
drug release from the formulated tablets. Lactose facilitated drug release from barrier layers. Substantial water uptake and
gelling of xanthan gum appears to be responsible for sustained drug release. The present study underlines the importance of
formulation factors in achieving same drug release pattern from three strengths of venlafaxine hydrochloride tablets. 相似文献
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《Bioscience, biotechnology, and biochemistry》2013,77(10):2165-2171
This study describes the effects of mixtures of xanthan gum and galactomannan, guar gum, or locust bean gum, on the lipids in plasma and liver in non-diabetic and diabetic rats. Non-diabetic rats were fed cholesterol-free diets with 3% guar gum, locust bean gum, or xanthan gum (3G, 3L, and 3X), or a mixture of xanthan gum and guar gum or locust bean gum (1:2, w/w) (2G1X, 2L1X) for 2 weeks. Rats fed diets not containing these polysaccharides were used as controls. The total cholesterol in plasma and the triacylglycerol in liver were significantly lowered in rats fed the 2G1X diet. The 3G, 3X, 3L, and 2L1X diets showed no significant effect on the total cholesterol and triacylglycerol in plasma and liver. In the streptozotocin-induced (STZ) diabetic rats, the total cholesterol in plasma was lowered in rats fed the 3G, 3X or 2G1X diet for 4 weeks, and the 2G1X diet was more effective than the 3G and 3X diets. The triacylglycerol in plasma in STZ diabetic rats was also significantly lowered by the 2G1X diet. These results showed that a mixture of xanthan gum and guar gum has an improved hypolipidemic effect on non-diabetic and STZ diabetic rats. The effects of the 2G1X diet on the diabetic symptoms in STZ diabetic rats, suppression of food and water intakes, decrease in glucose in urine, and lowering of plasma glucose, were also observed. 相似文献
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The purpose of this study was to investigate the formulation variables influencing the drug release from the layered tablets
containing chitosan and xanthan gum as matrix component. Increasing the amount of lactose could diminish pH sensitive release
behavior of these matrix tablets. Effect of formulation variables on drug release from the prepared three-layered matrix tablets
was investigated. The amount of drug loading did not affect the drug release which was influenced by the hydrodynamic force
and the matrix composition. An increase in stirring rate correspondingly increased the release rate. Moreover, incorporation
of soluble diluents in core or barrier could enhance the drug release. Least square fitting the experimental dissolution data
to the mathematical expressions (power law, first order, Higuchi’s and zero order) was carried out to study the drug release
mechanism. Most dissolution profiles of the prepared three-layered tablets provided a better fit to zero order kinetic than
to first order kinetic and Higuchi’s equation. 相似文献