Generation and anisotropy of neutron emission from a condensed Z-pinch

The paper presents results of measurements of neutron emission generated in the constriction of a fast Z-pinch at the S-300 facility (2 MA, 100 ns). An increased energy concentration was achieved by using a combined load the central part of which was a microporous deuterated polyethylene neck with a mass density of 100 mg/cm³ and diameter of 1–1.5 mm. The neck was placed between two 5-mm-diameter agar-agar cylinders. The characteristics of neutron emission in two axial and two radial directions were measured by the time-of-flight method. The neutron spectrum was recovered from the measured neutron signals by the Monte Carlo method. In all experiments, the spatiotemporal characteristics of plasma in the Z-pinch constriction were measured by means of the diagnostic complex of the S-300 facility, which includes frame photography in the optical, VUV, and soft X-ray (SXR) spectral regions; optical streak imaging; SXR detection; and time-integrated SXR photography. The formation of hot dense plasma in the Z-pinch constriction was accompanied by the generation of hard X-ray (with photon energies E > 30 keV), SXR (with photon energies E > 1 keV and duration of 2–4 ns), and neutron emission. Anisotropy of the neutron energy distribution in the axial direction was revealed. The mean neutron energies measured in four directions at angles of 0° (above the anode), 90°, 180° (under the cathode), and 270° with respect to the load axis were found to be of 2.1 ± 0.1, 2.5 ± 0.1, 2.6 ± 0.2, and 2.4 ± 0.1 MeV, respectively. For a 1-mm-diameter neck, the maximum integral neutron yield was 6 × 10⁹ neutrons. The anisotropy of neutron emission for a Z-pinch with a power-law distribution of high-energy ions is calculated.     

X-pinch-based neutron source

Results are presented from experimental studies of the parameters of an X-pinch-based neutron source made of 70- to 80-μm-diameter deuterated polyethylene fibers. At currents of up to 1.7 MA and a current rise time of ～150 ns, hot plasma spots were observed in the fiber crossing region. The formation of hot spots was accompanied by the generation of short soft X-ray pulses with a duration of 2–4 ns, as well as by neutron emission. The neutron energy was measured using the time-of-flight technique in four directions, at 0°, 90°, 180°, and 270° with respect to the load axis. The mean energy of the neutrons emitted along the axis towards the anode and cathode was found to be 2.0 ± 0.2 and 2.6 ± 0.1 MeV, respectively, and that of neutrons emitted in two opposite directions along the radius, 2.5 ± 0.1 and 2.4 ± 0.1 MeV. The maximum neutron yield at a current amplitude of 1.6 MA was of 10¹⁰ neutrons per shot.     

Measurements of neutron emission from a Z-pinch constriction

Results are presented from measurements of neutron emission generated during discharges with current amplitudes of up to 3 MA and a current rise time of ～100 ns through profiled loads 10 mm in height and 4–5 mm in diameter. The experiments were performed with the S-300 eight-module high-power generator. To enhance the effect of energy accumulation, a≤1-mm-diameter neck was made in the central region of the load. An agar-agar foam of mass density 0.1 g/cm³ with an additive of deuterated polyethylene was used as a plasma-forming material. The formation of a hot plasma in the Z-pinch constriction was accompanied by the emission of soft X-ray (E = 1–10 keV), hard X-ray (E ≥ 30 keV), and neutron pulses with a minimum pulse duration of ≤10 ns. The neutron energy measured by the time-of-flight technique in three directions relative to the load axis (0°, 90°, and 180°) was found to be 2.5 ± 0.3 MeV, which corresponds to the dd reaction. The total neutral yield during the development of one constriction with a characteristic size of 100 μm attained 10⁸ neutrons per pulse.     

Neutron emission during the implosion of a wire array onto a deuterated fiber

Results are presented from Z-pinch experiments performed in the S-300 facility (Kurchatov Institute) at a maximum current of 2 MA and current rise time of 100 ns. The Z-pinch load was a 1-cm-long 1-cmdiameter cylindrical array made of 40 tungsten wires with a total mass of 160 μg, at the axis of which a 100-μm-diameter (CD₂) _n deuterated fiber was installed. Hard X-ray and neutron signals were recorded using five scintillation detectors oriented in one radial and two axial directions. The maximum neutron yield from the DD reaction reached 3 × 10⁹ neutrons per shot. The average neutron energy was determined from time-of-flight measurements and Monte Carlo simulations under the assumption that the neutron emission time was independent of the neutron energy. The average neutron energy in different experiments was found to vary within the range 2.5–2.7 MeV. The fact that the average neutron energy was higher than 2.45 MeV (the energy corresponding to the DD reaction) is attributed to the beam-target collisional mechanism for the acceleration of deuterons to 100–500 keV.     

Determination of the thermal and epithermal neutron sensitivities of an LBO chamber

An LBO (Li₂B₄O₇) walled ionization chamber was designed to monitor the epithermal neutron fluence in boron neutron capture therapy clinical irradiation. The thermal and epithermal neutron sensitivities of the device were evaluated using accelerator neutrons from the ⁹Be(d, n) reaction at a deuteron energy of 4 MeV (4 MeV d-Be neutrons). The response of the chamber in terms of the electric charge induced in the LBO chamber was compared with the thermal and epithermal neutron fluences measured using the gold-foil activation method. The thermal and epithermal neutron sensitivities obtained were expressed in units of pC cm², i.e., from the chamber response divided by neutron fluence (cm^?2). The measured LBO chamber sensitivities were 2.23 × 10^?7 ± 0.34 × 10^?7 (pC cm²) for thermal neutrons and 2.00 × 10^?5 ± 0.12 × 10^?5 (pC cm²) for epithermal neutrons. This shows that the LBO chamber is sufficiently sensitive to epithermal neutrons to be useful for epithermal neutron monitoring in BNCT irradiation.     

Correlation between the neutron yield from a plasma focus device and the jump in the discharge current

The correlation between the neutron yield Y from a plasma focus device and the jump in the discharge current ??I has been studied experimentally. The total yield of the DD neutron source was measured by the method of activation of silver isotopes. The time dependences of the neutron and ??-radiation yields were recorded using scintillation detectors. It is found that, for the given experimental device, the neutron yield depends linearly on the jump in the discharge current ??I at the instant of neutron generation. The influence of the initial deuterium pressure in the discharge chamber on this dependence is examined.     

A source with a 1013 DT neutron yield on the basis of a spherical plasma focus chamber

Results from preliminary experimental research of neutron emission generated by a spherical plasma focus chamber filled with an equal-component deuterium-tritium mixture are presented. At a maximum current amplitude in the discharge chamber of ～1.5 MA, neutron pulses with a full width at half-maximum of 75–80 ns and an integral yield of ～1.3 × 10¹³ DT neutrons have been recorded.     

RBE of quasi-monoenergetic 60 MeV neutron radiation for induction of dicentric chromosomes in human lymphocytes

The production of dicentric chromosomes in human lymphocytes by high-energy neutron radiation was studied using a quasi-monoenergetic 60 MeV neutron beam. The average yield coefficient of the linear dose–response relationship for dicentric chromosomes was measured to be (0.146±0.016) Gy⁻¹. This confirms our earlier observations that above 400 keV, the yield of dicentric chromosomes decreases with increasing neutron energy. Using the linear-quadratic dose–response relationship for dicentric chromosomes established in blood of the same donor for ⁶⁰Co γ-rays as a reference radiation, an average maximum low-dose RBE (RBE_M) of 14±4 for 60 MeV quasi-monoenergetic neutrons with a dose-weighted average energy of 41.0 MeV is obtained. A correction procedure was applied, to account for the low-energy continuum of the quasi-monoenergetic spectral neutron distribution, and the yield coefficient α for 60 MeV neutrons was determined from the measured average yield coefficient . For α, a value of (0.115±0.026) Gy⁻¹ was obtained corresponding to an RBE_M of 11±4. The present experiments extend earlier investigations with monoenergetic neutrons to higher energies.     

Measurements of the parameters of a condensed deuterated Z-pinch on the angara-5-1 facility

Results are presented from measurements of the parameters of high-temperature plasma in the Z-pinch neck formed when a current of up to 3.5 MA flows through a low-density polymer load. To enhance the effect of energy concentration, a deuterated microporous polyethylene neck with a mass density of 100 mg/cm³ and diameter of 1–1.3 mm was placed in the central part of the load. During the discharge current pulse, short-lived local hot plasma spots with typical dimensions of about 200–300 μm formed in the neck region. Their formation was accompanied by the generation of soft X-ray pulses with photon energies of E > 0.8 keV and durations of 3–4 ns. The plasma electron temperature in the vicinity of the hot spot was measured from the vacuum UV emission spectra of the iron diagnostic admixture and was found to be about 200–400 eV. The appearance of hot plasma spots was also accompanied by neutron emission with the maximum yield of 3 × 10¹⁰ neutrons/shot. The neutron energy spectra were studied by means of the time-of-flight method and were found to be anisotropic with respect to the direction of the discharge current.     

Aspects in practical neutron dosimetry with ionization chambers

Summary The calibration procedure to determine the absorbed dose within a phantom irradiated with fast neutrons is described for ionization chambers. A comparison between values of the neutron dose determined with paired ionization chambers and values of the neutron fluence measured with a fission chamber (²³⁸U) is given. The comparison indicates the energy variation of the fast neutrons within a phantom irradiated with 14 MeV neutrons.Dedicated to Prof. Dr. Dr. h. c. mult. B. Rajewsky on the occasion of his 80th birthday.     

RBE of thermal neutrons for induction of chromosome aberrations in human lymphocytes

The induction of chromosome aberrations in human lymphocytes irradiated in vitro with slow neutrons was examined to assess the maximum low-dose RBE (RBE_M) relative to ⁶⁰Co γ-rays. For the blood irradiations, cold neutron beam available at the prompt gamma activation analysis facility at the Munich research reactor FRM II was used. The given flux of cold neutrons can be converted into a thermally equivalent one. Since blood was taken from the same donor whose blood had been used for previous irradiation experiments using widely varying neutron energies, the greatest possible accuracy was available for such an estimation of the RBE_M avoiding the inter-individual variations or differences in methodology usually associated with inter-laboratory comparisons. The magnitude of the coefficient α of the linear dose–response relationship (α = 0.400 ± 0.018 Gy^?1) and the derived RBE_M of 36.4 ± 13.3 obtained for the production of dicentrics by thermal neutrons confirm our earlier observations of a strong decrease in α and RBE_M with decreasing neutron energy lower than 0.385 MeV (RBE_M = 94.4 ± 38.9). The magnitude of the presently estimated RBE_M of thermal neutrons is—with some restrictions—not significantly different to previously reported RBE_M values of two laboratories.     

Implosion dynamics of condensed Z-pinch at the Angara-5-1 facility

The implosion dynamics of a condensed Z-pinch at load currents of up to 3.5 MA and a current rise time of 100 ns was studied experimentally at the Angara-5-1 facility. To increase the energy density, 1- to 3-mm-diameter cylinders made of a deuterated polyethylene?agar-agar mixture or microporous deuterated polyethylene with a mass density of 0.03–0.5 g/cm³ were installed in the central region of the loads. The plasma spatiotemporal characteristics were studied using the diagnostic complex of the Angara-5-1 facility, including electron-optical streak and frame imaging, time-integrated X-ray imaging, soft X-ray (SXR) measurements, and vacuum UV spectroscopy. Most information on the plasma dynamics was obtained using a ten-frame X-ray camera (Е > 100 eV) with an exposure of 4 ns. SXR pulses were recorded using photoemissive vacuum X-ray detectors. The energy characteristics of neutron emission were measured using the time-offlight method with the help of scintillation detectors arranged along and across the pinch axis. The neutron yield was measured by activation detectors. The experimental results indicate that the plasma dynamics depends weakly on the load density. As a rule, two stages of plasma implosion were observed. The formation of hot plasma spots in the initial stage of plasma expansion from the pinch axis was accompanied by short pulses of SXR and neutron emission. The neutron yield reached (0.4–3) × 10¹⁰ neutrons/shot and was almost independent of the load density due to specific features of Z-pinch dynamics.     

Research of the small plasma focus with an auxiliary electrode at deuterium filling

The research was provided on the small plasma focus device with the Mather-type electrodes in configuration with an auxiliary electrode placed in front of the anode. It works at the current maximum of 200 kA. The total neutron yield from D-D reaction reaches 10⁵–10⁷ per one shot. The hard X-rays and neutrons were detected with scintillation detectors and the soft X-rays with a PIN detector and four MCP frames. We present preliminary results obtained from different configurations of the anode (inner electrode) and auxiliary electrode and we compare these results with that obtained in configuration without auxiliary electrode. The auxiliary electrode decreased both the neutron yield and the time of hard X-ray and neutron production. Different electrode faces has influence on the energy distribution of generated neutrons.     

Dosimetric effect of limited aperture multileaf collimator on VMAT plan quality: A study of prostate and head-and-neck cancers

Aim

The aim of study was to evaluate the dosimetric effect of collimator-rotation on VMAT plan quality, when using limited aperture multileaf collimator of Elekta Beam Modulator? providing a maximum aperture of 21 cm × 16 cm.

Formation of hot spots in the plasma of a Z-pinch produced from low-density deuterated polyethylene

Results are presented from experimental studies of the plasma formation dynamics in a Z-pinch produced from a cylindrical microporous agar-agar load. The experiments were performed on the S-300 facility at a current of 2 MA and current rise time of 100 ns. To enhance the energy concentration, a deuterated polyethylene neck with a mass density of 50–75 μg/cm³ and diameter of 1–2 mm was made in the central part of the load. The spatiotemporal characteristics of the Z-pinch were studied using an optical streak camera and fast frame photography in the optical and soft X-ray spectral ranges. X-ray emission was detected using semiconductor and vacuum diodes, and neutron emission was studied by means of the time-of-flight method. It is found that, in the course of continuous plasma production, hot spots with a diameter of 100 μm form in the pinch plasma. The hot spots emit short soft X-ray pulses with a duration of 2–4 ns, as well as neutron pulses with an average neutron energy of about 2.45 MeV. The maximum neutron yield was found to be 4.5 × 10⁹ neutrons per shot. The scenario of hot spot formation is adequately described by two-dimensional MHD simulations.     

The lipid integrity of membranes of guinea pig alveolar macrophages studied by nanosecond fluorescence decay of 1,6-diphenyl-1,3,5-hexatriene: The effect of stimulation by concanavalin A and formyl peptides1

Time-resolved fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene was used to monitor physical changes in the membranes of guinea pig alveolar macrophages following stimulation by N-formyl peptides (either N-formylmethionylphenylalanine (FMP) or N-formyl methionyl leucylphenylalanine (FMLP)) and concanavalin A. The anisotropy of diphenylhexatriene in macrophages showed a dependence on stimulation both in the rate of decay and in the value of anisotropy at infinite time. Subtle differences were observed between the effect of concanavalin A and FMLP on the membrane lipid fluidity as detected by fluorescence anisotropy. Concanavalin A stimulation of macrophages decreased the value of the anisotropy at infinite times in the range of 0–20 °C and increased the value at 25–40 °C; and at all temperatures it decreased the rate of decay of anisotropy. At temperatures below 25 °C, the response to FMLP was similar to concanavalin A, but above 25 °C, FMLP only slightly modified the anisotropy decay profile. Another physical parameter, calcium permeability, was examined because Ca⁺² fluxes are dependent upon membrane properties. The temperature-dependent profiles of concanavalin A and FMP-stimulated ⁴⁵Ca⁺² efflux from alveolar macrophages were similar. The rate and extent of ⁴⁵Ca⁺² efflux increased from 4 to 22 °C, with no further increases observed up to 37 °C. This pattern correlated well with observed changes in membrane fluidity.     

Quantum-chemical and empirical calculations on phospholipids: V. Conformational calculations on model headgroups with varying ammonium group methylation

Using empirical 0-1-6-12 atom-atom potential functions and the PCILO method the conformational properties of anhydrous and hydrated model headgroups with varying ammonium group methylation were investigated. With a phosphoryl gauche^(?)-gauche^(?) conformation the torsion angle α₄ lies in the region of 180°–300° for all compounds. Torsion angles α₄ = 300° ? 100° are forbidden due to intramolecular sterical hindrance. The torsion angles α₅ and α₆ are influenced by the stage of ammonium group methylation and bound water molecules. The minima of energy with respect to α₅ were found at an ± syn-clinal (and for PC and DMPE + H₂O at an anti-periplanar) conformation.     

Isometric torque–angle relationships of the elbow flexors and extensors in the transverse plane

Maximal voluntary isometric torque–angle relationships of elbow extensors and flexors in the transverse plane (humerus elevation angle of 90°) were measured at two different horizontal adduction angles of the humerus compared to thorax: 20° and 45°. For both elbow flexors and extensors, the torque–angle relationship was insensitive to this 25° horizontal adduction of the humerus. The peak in torque–angle relationship of elbow extensors was found at 55° (0° is full extension). This is closer to full elbow extension than reported by researchers who investigated this relationship in the sagittal plane. Using actual elbow angles during contraction, as we did in this study, instead of angles set by the dynamometer, as others have done, can partly explain this difference.We also measured electromyographic activity of the biceps and triceps muscles with pairs of surface electrodes and found that electromyographic activity level of the agonistic muscles was correlated to measured net torque (elbow flexion torque: Pearson’s r = 0.21 and extension torque: Pearson’s r = 0.53). We conclude that the isometric torque–angle relationship of the elbow extensors found in this study provides a good representation of the force–length relationship and the moment arm–angle relationship of the elbow extensors, but angle dependency of neural input gives an overestimation of the steepness.     

Effect of temperature on membrane fluidity and calcium conductance of the excitable ciliary membrane from Paramecium

Fluorescence anisotropy and average fluorescence lifetime of diphenylhexatriene were measured in artificial lipid membrane vesicles. Within the temperature range investigated (15–52°C) both parameters correlate and can be used interchangeably to measure membrane fluidity. Fluorescence anisotropy of DPH in membrane vesicles of cilia from the protozoan Paramecium tetraurelia decreased slightly from 5 to 37°C, yet, no phase transition was observed. An estimated flow activation energy of approx. 2 kcal/mol indicated that the ciliary membrane is very rigid and not readily susceptible to environmental stimuli. The ciliary membrane contains two domains of different membrane fluidity as indicated by two distinct fluorescence lifetimes of diphenylhexatriene of 7.9 and 12.4 ns, respectively. Ca²⁺ flux into ciliary membrane vesicles of Paramecium as measured with the Ca²⁺ indicator dye arsenazo III showed a nonlinear temperature dependency from 5 to 35°C with a minimum around 15°C and increasing flux rates at higher and lower temperatures. The fraction of vesicles permeable for Ca²⁺ remained unaffected by temperature. The differences in temperature dependency of Ca²⁺ conductance and membrane fluidity indicate that the Ca²⁺ permeability of the ciliary membrane is a membrane property which is not directly affected by the fluidity of its lipid environment.     

Development and study of a portable plasma focus neutron source

The work is devoted to designing a compact pulsed neutron source on the basis of a plasma focus (PF) discharge. The main task was to study the physical processes accompanying a sub-kilojoule repetitive PF discharge. A device with a power supply energy of up to 600 J and pulse repetition rate of up to 10 Hz has been developed and put into operation. The dependence of the neutron yield as a function of the pulse repetition rate has been studied experimentally. A neutron flux of ～10⁸ neutrons/s has been obtained in the 3-s-long packet mode with a repetition rate of 10 Hz and discharge current of 80–90 kA.