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PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation
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Lee JA Lee SH Lee C Chang DJ Lee Y Kim H Cheang YH Ko HG Lee YS Jun H Bartsch D Kandel ER Kaang BK 《The Journal of cell biology》2006,174(6):827-838
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Ubiquitin-mediated proteolysis in learning and memory 总被引:2,自引:0,他引:2
Sensitization of defensive reflexes inAplysia is a simple behavioral paradigm for studying both short- and long-term memory. In the marine mollusk, as in other animals,
memory has at least two phases: a short-term phase lasting minutes and a long-term phase lasting several days or longer. Short-term
memory is produced by covalent modification of pre-existing proteins. In contrast, long-term memory needs gene induction,
synthesis of new protein, and the growth of new synapses. The switch from short-term (STF) to long-term facilitation (LTF)
inAplysia sensory neurons requires not only positive regulation through gene induction, but also the specific removal of several inhibitory
proteins. One important inhibitory protein is the regulatory (R) subunit of the cAMP-dependent protein kinase (PKA). Degradation
of R subunits, which is essential for initiating long-term stable memory, occurs through the ubiquitin-proteasome pathway. 相似文献
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