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Cho JY Akbarali Y Zerbini LF Gu X Boltax J Wang Y Oettgen P Zhang DE Libermann TA 《The Journal of biological chemistry》2004,279(19):19512-19522
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J H Kim S Lee J K Rho S Y Choe 《The international journal of biochemistry & cell biology》1999,31(9):933-940
The human CR1 gene is expressed specifically in hematopoietic cells. It is suggested that some cell-type specific factors which involve in gene-specific activation or repression exist in cells according to the result that the gene expression varies differently depend on differentiation stage. Here, we demonstrate that the integrity of a polyomavirus enhancer core sequence, 5'-TGTGGT-3', is critical to the human CR1 promoter activity. AML1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. We show that the AML1 binds specifically to this site and activates the human CR1 promoter. Furthermore, we demonstrate that the Ets binding site (GGAA) located 2 bp upstream of the AML1 site is also involved in the regulation of the human CR1 promoter activity. Point mutations of either the AML1 or the Ets binding site that abolish the binding of the respective factors result in significant decreases of the human CR1 promoter activity. These results suggest that AML1 and Ets proteins direct the expression of the human CR1 promoter. 相似文献
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Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy
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Okuda T Takeda K Fujita Y Nishimura M Yagyu S Yoshida M Akira S Downing JR Abe T 《Molecular and cellular biology》2000,20(1):319-328
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