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Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction. 相似文献
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Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1 总被引:6,自引:0,他引:6
Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1alpha (HIF-1alpha). Moreover, 5'-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin. Mutation of these HREs in the visfatin promoter abrogates activation of a luciferase reporter gene driven by visfatin promoter under hypoxia. Taken together, our results demonstrate that visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region. 相似文献
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范新明周鸣彭建强郭莹 《现代生物医学进展》2011,11(20):3994-3996
缺氧诱导因子(HIF)是参与缺氧转录反应调控的转录调控因子,HIF的活化在缺氧时细胞中保护起重要作用,HIF及HIF依赖的基因如诱导型一氧化氮合酶(iNOS)、血红素氧合酶(HO-1)的激活可减轻心脏的缺血-再灌注损伤,HIF调节的基因表达可能介导了缺血预处理和缺血后处理的保护作用。本文对HIF在心肌缺血再灌注损伤中的保护作用予以综述。 相似文献
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Warnecke C Weidemann A Volke M Schietke R Wu X Knaup KX Hackenbeck T Bernhardt W Willam C Eckardt KU Wiesener MS 《Experimental cell research》2008,314(10):2016-2027
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Reactive oxygen species (ROS) and the heat stress response of Daphnia pulex: ROS‐mediated activation of hypoxia‐inducible factor 1 (HIF‐1) and heat shock factor 1 (HSF‐1) and the clustered expression of stress genes 下载免费PDF全文
Eva Klumpen Nadine Hoffschröer Bettina Zeis Ulrike Gigengack Elias Dohmen Rüdiger J. Paul 《Biology of the cell / under the auspices of the European Cell Biology Organization》2017,109(1):39-64