共查询到20条相似文献,搜索用时 15 毫秒
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Kellie A. Rance Jean-Michel Fustin Gillian Dalgleish Catherine Hambly Lutz Bünger John R. Speakman 《Mammalian genome》2005,16(8):567-577
Body mass (BM) is a classic polygenic trait that has been extensively investigated to determine the underlying genetic architecture.
Many previous studies looking at the genetic basis of variation in BM in murine animal models by quantitative trait loci (QTL)
mapping have used crosses between two inbred lines. As a consequence it has not been possible to explore imprinting effects
which have been shown to play an important role in the genetic basis of early growth with persistent effects throughout the
growth curve. Here we use partially inbred mouse lines to identify QTL for mature BM by applying both Mendelian and Imprinting
models. The analysis of an F2 population (n ≈ 500) identified a number of QTL at 14, 16, and 18 weeks explaining in total 31.5%, 34.4%, and 30.5% of total phenotypic
variation, respectively. On Chromosome 8 a QTL of large effect (14% of the total phenotypic variance at 14 weeks) was found
to be explained by paternal imprinting. Although Chromosome 8 has not been previously associated with imprinting effects,
features of candidate genes within the QTL confidence interval (CpG islands and direct clustered repeats) support the hypothesis
that Insulin receptor substrate 2 may be associated with imprinting, but as yet is unidentified as being so. 相似文献
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Emma E. M. Knowles Samuel R. Mathias Josephine Mollon Amanda Rodrigue Marinka M. G. Koenis Thomas D. Dyer Harald H. H. Goring Joanne E. Curran Rene L. Olvera Ravi Duggirala Laura Almasy John Blangero David C. Glahn 《Genes, Brain & Behavior》2019,18(4)
Processing speed is a psychological construct that refers to the speed with which an individual can perform any cognitive operation. Processing speed correlates strongly with general cognitive ability, declines sharply with age and is impaired across a number of neurological and psychiatric disorders. Thus, identifying genes that influence processing speed will likely improve understanding of the genetics of intelligence, biological aging and the etiologies of numerous disorders. Previous genetics studies of processing speed have relied on simple phenotypes (eg, mean reaction time) derived from single tasks. This strategy assumes, erroneously, that processing speed is a unitary construct. In the present study, we aimed to characterize the genetic architecture of processing speed by using a multidimensional model applied to a battery of cognitive tasks. Linkage and QTL‐specific association analyses were performed on the factors from this model. The randomly ascertained sample comprised 1291 Mexican‐American individuals from extended pedigrees. We found that performance on all three distinct processing‐speed factors (Psychomotor Speed; Sequencing and Shifting and Verbal Fluency) were moderately and significantly heritable. We identified a genome‐wide significant quantitative trait locus (QTL) on chromosome 3q23 for Psychomotor Speed (LOD = 4.83). Within this locus, we identified a plausible and interesting candidate gene for Psychomotor Speed (Z = 2.90, P = 1.86 × 10?03). 相似文献
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