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Hachiya A Kodama EN Sarafianos SG Schuckmann MM Sakagami Y Matsuoka M Takiguchi M Gatanaga H Oka S 《Journal of virology》2008,82(7):3261-3270
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Ehteshami M Beilhartz GL Scarth BJ Tchesnokov EP McCormick S Wynhoven B Harrigan PR Götte M 《The Journal of biological chemistry》2008,283(32):22222-22232
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Blanca G Baldanti F Paolucci S Skoblov AY Victorova L Hübscher U Gerna G Spadari S Maga G 《The Journal of biological chemistry》2003,278(18):15469-15472
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Mikhail S. Novikov Vladimir T. Valuev-Elliston Denis A. Babkov Maria P. Paramonova Alexander V. Ivanov Sergey A Gavryushov Anastasia L. Khandazhinskaya Sergey N. Kochetkov Christophe Pannecouque Graciela Andrei Robert Snoeck Jan Balzarini Katherine L. Seley-Radtke 《Bioorganic & medicinal chemistry》2013,21(5):1150-1158
A series of phenyloxyethyl and cinnamyl derivatives of substituted uracils were synthesized and found to exhibit potent activity against HIV-RT and HIV replication in cell culture. In general, the cinnamyl derivatives proved superior to the phenyloxyethyl derivatives, however 1-[2-(4-methylphenoxy)ethyl]-3-(3,5-dimethylbenzyl)uracil (19) exhibited the highest activity (EC50 = 0.27 μM) thus confirming that the 3-benzyluracil fragment in the NNRTI structure can be regarded as a functional analogue of the benzophenone pharmacophore typically found in NNRTIs. 相似文献
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Cases-González CE Franco S Martínez MA Menéndez-Arias L 《Journal of molecular biology》2007,365(2):298-309