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Genome Editing—Principles and Applications for Functional Genomics Research and Crop Improvement 总被引:1,自引:0,他引:1
Genome editing technologies are powerful tools for studying gene function and for crop improvement. The technologies rely on engineered endonucleases to generate double stranded breaks (DSBs) at target loci. The DSBs are repaired through the error-prone non-homologous end joining (NHEJ) and homology-directed repair (HDR) pathways in cells, resulting in mutations and sequence replacement, respectively. In the widely used CRISPR/Cas9 system, the endonuclease Cas9 is targeted by a CRISPR small RNA to DNA sequence of interest. In this review, we describe the four available types of genome editing tools, ZFN, TALEN, CRISPR/Cas9 and CRISPR/Cpf1, and show their applications in functional genomics research and precision molecular breeding of crops. 相似文献
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Phytochemistry Reviews - 相似文献
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Xin Zhang 《基因组蛋白质组与生物信息学报(英文版)》2004,2(1):59-63
The Beijing Genomics Institute (BGI) of Chinese Academy of Sciences (CAS) was officially founded in December 2003. Its predecessor, Beijing Huada Genomics Research Center, has presented significant contributions to the development of life sciences in China by its excellent scientific innovations and 相似文献
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Mustonen Tero Maxwell Kimberley H. Mustonen Kaisu Jones Russ Pedersen Halfdan Nuunoq Graham Jamie Greeno Dean Hugu Suteji Fischer Mibu Murtom?ki Eero 《Reviews in Fish Biology and Fisheries》2022,32(1):17-17
Reviews in Fish Biology and Fisheries - A correction to this paper has been published: https://doi.org/10.1007/s11160-021-09657-9 相似文献
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Jenni Menon Mariano 《应用发育科学》2013,17(3):139-147
Applying latent class and regression techniques to data from the NICHD Study of Early Child Care and Youth Development (n = 997), this study explored the potential academic advantages of time spent in out-of-school activities. Of particular interest was how these potential advantages played out in relation to the timing and duration of activity participation and the family contexts in which it occurred. Participation closer to the start of high school—including consistent participants and latecomers—was associated with higher grades at the transition into high school, especially for youth from low-income families. Sensitivity analyses indicated that this link between school-age activity participation and adolescent academic progress was unlikely to be solely a function of selection. It also tended to be more pronounced among youth from lower-income families, although without varying by other aspects of family status or process. 相似文献
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Amy B. H. Greenwell 《Economic botany》1947,1(3):276-289
A staple food since ancient times for countless Pacific island natives, taro may today be entering a new era of utilization by way of the baker’s flour manufactured from it and other comestibles such as poi and paiai derived from its corm. 相似文献
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Ten years ago, the Chinese National Human Genome Center at Shanghai (South Center,hereafter) was established in the Zhangjiang HiTech 相似文献
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Castagna Michela Cinquetti Raffaella Verri Tiziano Vacca Francesca Giovanola Matteo Barca Amilcare Romanazzi Tiziana Roseti Cristina Galli Alessandra Bossi Elena 《Neurochemical research》2022,47(1):111-126
To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.
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Malcolm S. M. Watts 《The Western journal of medicine》1964,101(6):417-421
The Committee to Study the Role of Medicine of the California Medical Education and Research Foundation (CMERF) is grateful to Dr. Watts for the following paper which served as the philosophical basis for the Committee''s study and discussions. The Committee is also grateful to CMERF and to its president, James C. Doyle, for the encouragement and cooperation it has received in the course of its intensive study of a problem which is of great interest and concern to the medical profession of California.Dr. Watts'' background paper has served as a potent stimulus in directing the Committee''s attention to the continuing dialogue between medicine and society, and in focussing on problems and issues which will be the subject of the Committee''s Second Progress Report, excerpts from which are scheduled for publication in the next issue of California Medicine. 相似文献