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Christine Neuveut Robert M. Scoggins David Camerini Richard B. Markham Kuan-Teh Jeang 《Journal of biomedical science》2003,10(6):651-660
HIV-1 Tat is essential for virus replication and is a potent transactivator of viral gene expression. Evidence suggests that Tat also influences virus infectivity and cytopathicity. Here, we find that the second coding exon of Tat contributes a novel function for the replication/infectivity of macrophage-tropic HIV-1. We show that macrophage-tropic HIV-1 which expresses the full-length two-exon form of Tat replicates better in monocyte-derived macrophages (MDM) than an otherwise isogenic virus which expresses only the one-exon form of Tat. Similarly, two-exon Tat expressing HIV-1 also replicates better than one-exon Tat expressing HIV-1 in two different models of human cells/tissue reconstituted SCID mice. 相似文献
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Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues 下载免费PDF全文
Bouchonnet F Dam E Mammano F de Soultrait V Henneré G Benech H Clavel F Hance AJ 《Journal of virology》2005,79(2):812-822
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The Tat protein of human immunodeficiency virus type 1 (HIV-1) can promote placement of tRNA primer onto viral RNA and suppress later DNA polymerization in HIV-1 reverse transcription 下载免费PDF全文
Kameoka M Morgan M Binette M Russell RS Rong L Guo X Mouland A Kleiman L Liang C Wainberg MA 《Journal of virology》2002,76(8):3637-3645
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F Lori F di Marzo Veronese A L de Vico P Lusso M S Reitz Jr R C Gallo 《Journal of virology》1992,66(8):5067-5074
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