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<正>马尔尼菲青霉(Penicillium marniffei,PM)是青霉属中惟一的双相真菌。PM可引起局限性和播散性感染,其在HIV流行前播散性马尔尼菲青霉病(penicilliosis marneffei,PSM)是一种罕见的真菌疾病,主要见于免疫受损的宿主。随着艾滋病的流行,有关该菌感染的报道日渐增多已成为我国南方艾滋病(AIDS)患者重要的机会性感染病原菌之一,是 相似文献
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马尔尼菲青霉病的临床诊断进展 总被引:1,自引:0,他引:1
马尔尼菲青霉病(penicilliosis marneffei,PSM)是由致病真菌马尔尼菲青霉(Penicilliummarniffei,PM)所引起的一种深部真菌病,属地方流行病,好发于各种原因引起的免疫抑制患者,是东南亚地区艾滋病患者最常见的机会性感染之一,误诊率极高[1]。目前WHO已经把它作为AIDS的指征性疾病。我国报道的散发性病例多集中在中国南部,如广西、广东、云南等省,及有东南亚旅居史的人群中。本文就马尔尼菲青霉病的临床诊断进展作一综述。1真菌学诊断真菌培养是确定病原菌最为可靠的方法,从体内分离出PM是诊断马尔尼菲青霉病的金标准。马尔尼菲青霉菌是… 相似文献
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艾滋病合并马尔尼菲青霉病256例临床研究 总被引:3,自引:0,他引:3
目的探讨艾滋病合并马尔尼菲青霉病的流行病学、临床特点、早期确诊方法及治疗方案。方法对2007年1月-2008年12月我院收治的256例艾滋病合并马尔尼菲青霉病患者的临床资料进行回顾性分析。结果1 404例艾滋病患者中合并马尔尼菲青霉病者共256例,发生率为18.2%,患者以发热、消瘦、贫血、咳嗽、咳痰、皮疹、淋巴结肿大为主要表现,外周血CD4+T淋巴细胞平均值为19×10^6/L,患者往往还合并其他多种机会性感染,以口腔念珠菌病、耶氏肺孢子菌肺炎、结核病等多见。两性霉素B治疗组临床疗效优于氟康唑治疗组,伴有皮疹者和无皮疹者病死率差异有统计学意义(P〈0.001)。结论马尔尼菲青霉病是广西艾滋病患者常见的机会性感染之一,主要发生于CD4+T淋巴细胞〈50×10^6/L的患者。血培养是早期确诊马尔尼菲青霉病的最有效方法,治疗上首选两性霉素B。 相似文献
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目的探讨艾滋病合并马尔尼菲青霉病的临床表现,治疗与转归。方法回顾分析本院2008年8月~2009年8月收治的艾滋病合并马尔尼菲青霉36例。结果 36例艾滋病合并马尔尼菲青霉病平均年龄35.8岁。马尔尼菲青霉感染临床表现呈现非特异性,其中发热86.11%,贫血94.44%,GGT升高69.44%,AST升高63.89%,淋巴结肿大88.89%,脾大63.89%,低蛋白血症83.33%,咳嗽36.11%,皮损30.56%(其中典型改变仅5例,占13.89%),CD4+50cells/mm388.89%,骨髓培养(27/27)及皮损活检培养(2/2)阳性率100%,血液培养阳性率69.44%(25/36)。36例经抗真菌治疗,其中29例给予HAART治疗,28例治愈,7例好转,1例死亡。结论马尔尼菲青霉是艾滋病常见的机会性感染,早发现,早治疗,长程敏感抗真菌药物联合治疗可提高治愈率,减少复发。 相似文献
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马尔尼菲青霉与马尔尼菲青霉病 总被引:4,自引:0,他引:4
马尔尼菲青霉(Penicillium marneffei,PM),现在已成为东南亚地区艾滋病最常见的机会性感染的病原体之一。马尔尼菲青霉病(Penicilliosis marneffei,PSM)是由PM引起的一种真菌感染性疾病。PM主要侵犯单核巨噬细胞系统,临床表现复杂多样。虽然血清学诊断可能提高对PM的认识和早期潜伏期病例的诊断,但是PSM的确诊有赖于真菌学检查——从体内分离出PM是诊断的金标准。PSM是一种致死性疾病,系统性抗真菌药物治疗是唯一可靠的治疗方法。 相似文献
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为探讨和总结非人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者发生马尔尼菲青霉病的临床特点,回顾性研究复旦大学附属华山医院感染科2007年1月-2017年8月收治的9例及同期发表文献中的马尔尼菲青霉病病例,分析其临床表现、实验室检查、治疗及转归。9例马尔尼菲青霉病患者的HIV检测均为阴性,5例CD4+ T细胞计数正常。非HIV感染马尔尼菲青霉病的起病较缓,临床表现与经典马尔尼菲青霉病类似,真菌血症较少见,病理特点以肉芽肿改变及化脓性炎症为主,诊断方法仍以培养为主(8/9),1例通过病理及二代测序技术诊断。目前,非HIV感染马尔尼菲青霉病发病率有升高趋势,部分发生于免疫正常人群,需引起临床医师的重视。 相似文献
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In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980. 相似文献
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N. P. Vesselkin Yu. V. Natochin 《Journal of Evolutionary Biochemistry and Physiology》2010,46(6):592-603
Evolution of living organisms is closely connected with evolution of structure of the system of regulations and its mechanisms.
The functional ground of regulations is chemical signalization. As early as in unicellular organisms there is a set of signal
mechanisms providing their life activity and orientation in space and time. Subsequent evolution of ways of chemical signalization
followed the way of development of delivery pathways of chemical signal and development of mechanisms of its regulation. The
mechanism of chemical regulation of the signal interaction is discussed by the example of the specialized system of transduction
of signal from neuron to neuron, of effect of hormone on the epithelial cell and modulation of this effect. These mechanisms
are considered as the most important ways of the fine and precise adaptation of chemical signalization underlying functioning
of physiological systems and organs of the living organism 相似文献