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Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia 总被引:2,自引:1,他引:1
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Margolis TP Elfman FL Leib D Pakpour N Apakupakul K Imai Y Voytek C 《Journal of virology》2007,81(20):11069-11074
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Wen Huang Ping Zhao Xiao Chen Ping Li Gaonian Zhao Mingming Xu Xiuying Chen Peng Xie 《Cell biochemistry and biophysics》2014,68(1):159-162
This study aims to compare the different latent infections of herpes simplex virus type I in a murine model. One hundred and twenty BALB/c mice were randomly assigned into either of three groups: intravenous inoculation group, ocular abrasion group, and intranasal inoculation group. Six weeks later, the trigeminal ganglia (TG) were removed to detect the expression of HSV-I antigen. HSV DNA in TG was also detected by polymerase chain reaction to confirm latent infection. The rate of HSV DNA in TG detected in the intravenous inoculation group was 18/22 and 22/26 in the ocular abrasion group, both of which were higher than the rate detected in the intranasal inoculation group (18/30). The expression of HSV antigen in TG in these three groups was all negative. Mortality rate in the intravenous inoculation group was 8/30, which was much higher than those of the two other groups. Intranasal virus dripping, cornea abrasion, and intravenous injection can detect latent HSV-I infection in a murine model. Compared to two other groups, the cornea abrasion group showed less severe signs, a quicker recovery rate in acute infection, and higher incidence rate of latent infection. Therefore, it is an ideal method in the presence of latent HSV-I infection. 相似文献
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The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice
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Peng W Henderson G Inman M BenMohamed L Perng GC Wechsler SL Jones C 《Journal of virology》2005,79(10):6162-6171
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