Anthropological Approaches to Psychological Medicine: Crossing Bridges

Anthropological Approaches to Psychological Medicine: Crossing Bridges. Vieda Skultans and John Cox. London: Jessica Kingsley Publishers, 2000. 303 pp.     

Lead Poisoning: Using Transdisciplinary Approaches to Solve an Ancient Problem

Conservation medicine examines the linkages among the health of people, animals, and the environment. Few issues illustrate this approach better than an examination of lead (Pb) toxicity. Lead is cheap and there is a long tradition of its use. But the toxic effects of Pb have also been recognized for many years. As a result, western societies have eliminated or greatly reduced many traditional uses of Pb, including many paints, gasoline, and solders because of threats to the health of humans and the environment. Legislation in several countries has eliminated the use of lead shot for hunting waterfowl. Despite these advances, a great many Pb products continue to be readily available. For example, wildlife agencies recognize that angling and shooting sports deposit thousands of tons of Pb into the environment each year. In recent years, our knowledge of the lethal and sublethal effects of Pb has grown dramatically. This discussion reviews the effects of lead on wildlife, humans, and domestic animals. It also discusses the importance of bringing together all interest groups to find safe alternatives, to develop new educational and policy initiatives, to eliminate many current uses of Pb, and to clean up existing problems.     

Programmed Cell Death in Plants: Orchestrating an Intrinsic Suicide Program Within Walls

Plants are remarkable organisms in that they constantly adjust their growth and developmental patterns in response to changes in their environment. Part of this repertoire of dynamic readjustment of its body plan is the induction of programmed cell death in order to remove unwanted or unneeded cells and/or tissues. In addition, the programmed demise of specific cells can also be used to create specialized cell types, such as tracheary elements. In spite of its importance in the life of plants, the mechanistic understanding of how cell death is orchestrated remains poorly defined at the molecular and biochemical levels. In recent years, genetic and molecular studies are beginning to generate a growing list of good candidates for the central core of a possible cell death “engine”. These include the metacaspase protease family and the highly conserved plant orthologues to mammalian Bax Inhibitor-1. However, further characterization of the biochemical functions for these proteins and the resolution of the pathways that they work in would be necessary to achieve a comprehensive understanding of how cellular suicide is carried out in plants. In addition, critical definition of different plant cell death morphotypes via biochemical, molecular and genetic approaches will be important to delineate the complex interplay between different suicide pathways that appear to coexist and thus complicate their analysis.     

Gender, Suicide, and the Sociocultural Context of Deliberate Self-Harm in an Urban General Hospital in Mumbai, India

Recognizing the complementary effects of social contexts and psychiatric disorders, this study clarifies the role of gender in suicidal behavior in urban Mumbai by considering psychiatric diagnoses and patient-identified sociocultural features. The cultural epidemiological approach suggests the critical impact of situational sociocultural factors that complement the customary psychopathological accounts for those who harm or kill themselves. The cultural epidemiology of deliberate self-harm (DSH), it is argued, is critical to planning for suicide prevention, community mental health and psychiatric practice. This study, based on a cultural epidemiological framework, compares male and female admissions for DSH, evaluating conditions with SCID-I and EMIC interviews. We assessed features and narratives of suicidal behavior, patient-identified underlying problems, their perceived causes and triggers. The study included 92 women and 104 men. A diagnosis of depressive disorder was made for 48.9 percent of women and 39.4 percent of men. Many patients (50.0 percent of women and 41.3 percent of men) did not fulfill the criteria for any diagnosis, or did so only for an adjustment disorder or a V-code. Men typically explained DSH with reference to work problems, financial problems and problem drinking. Women typically discussed domestic problems, in-law relations and victimization. Problem drinking affected women living with men who drank. Social and situational factors appear to play a relatively greater role than psychiatric illness in self-harm and suicide in Mumbai, as in other Asian studies, compared with Europe and North America.     

Medieval Archaeology: Understanding Traditions and Contemporary Approaches

Medieval Archaeology: Understanding Traditions and Contemporary Approaches . Christopher Gerrard. New York: Routledge, 2003. 302 pp.     

Continuum Approaches to Understanding Ion and Peptide Interactions with the Membrane

Experimental and computational studies have shown that cellular membranes deform to stabilize the inclusion of transmembrane (TM) proteins harboring charge. Recent analysis suggests that membrane bending helps to expose charged and polar residues to the aqueous environment and polar head groups. We previously used elasticity theory to identify membrane distortions that minimize the insertion of charged TM peptides into the membrane. Here, we extend our work by showing that it also provides a novel, computationally efficient method for exploring the energetics of ion and small peptide penetration into membranes. First, we show that the continuum method accurately reproduces energy profiles and membrane shapes generated from molecular simulations of bare ion permeation at a fraction of the computational cost. Next, we demonstrate that the dependence of the ion insertion energy on the membrane thickness arises primarily from the elastic properties of the membrane. Moreover, the continuum model readily provides a free energy decomposition into components not easily determined from molecular dynamics. Finally, we show that the energetics of membrane deformation strongly depend on membrane patch size both for ions and peptides. This dependence is particularly strong for peptides based on simulations of a known amphipathic, membrane binding peptide from the human pathogen Toxoplasma gondii. In total, we address shortcomings and advantages that arise from using a variety of computational methods in distinct biological contexts.     

From Multiple Voices to a Common Language: Ecosystem Approaches to Human Health as an Emerging Paradigm

The International Forum on Ecosystem Approaches to Human Health, held in Montreal, May 18–23, 2003, was one product of a new paradigm or framework linking health, ecosystems, and sustainable development that emerged in recent decades. This profile aims to provide a backdrop for the contents of this supplementary issue by outlining some of the key principles of the Ecosystem Approaches to Human Health (Ecohealth) framework. It also discusses some of the activities supported by the Ecosystem Approaches to Human Health Program Initiative of the International Development Research Centre (IDRC) to build on the success of the Forum. In doing so, the intention is to frame the 2003 Forum as one in a series of opportunities to reflect and learn from precedents of research and practice from an ecohealth perspective and to foster the development of a community of practice on Ecohealth (COPEH). The profile not only places the contents of the supplement and the Forum within a larger context, but also provides an overview of other IDRC activities that are building capacity for future research and practice, and are strengthening the emerging COPEH.     

Activity as an Anthropological Category : On Distinguishing Between the Ontological and the Epistemological Status of Activity

This article is devoted to categorial and logical-semantic analysis of the concept "activity" in philosophy, methodology, and psychology. The basic activity-related subcategories are systematized and the normative structure of activity is revealed. The set of problems pertaining to the ontogenesis of activity-related abilities and to professional formation is defined in terms of the process of establishment of the subject of his own activity.