共查询到20条相似文献，搜索用时 15 毫秒
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《Current biology : CB》2022,32(1):64-73.e5
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Danielle Panoz-Brown Vishakh Iyer Lawrence M. Carey Christina M. Sluka Gabriela Rajic Jesse Kestenman Meredith Gentry Sydney Brotheridge Isaac Somekh Hannah E. Corbin Kjersten G. Tucker Bianca Almeida Severine B. Hex Krysten D. Garcia Andrea G. Hohmann Jonathon D. Crystal 《Current biology : CB》2018,28(10):1628-1634.e7
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Hippocampal principal neurons-'place cells'-exhibit location-specific firing. Recent work addresses the link between place cell activity and hippocampal memory function. New tasks that challenge spatial memory allow recording from single neurons, as well as ensembles of neurons, during memory computations, and insights into the cellular mechanisms of spatial memory are beginning to emerge. 相似文献
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睡眠和学习记忆同属于大脑最重要的基本功能．大量的动物实验和人体研究都证明睡眠在记忆巩固中发挥重要作用．综合此领域近年来的研究成果,着重阐述睡眠期间海马和皮层的记忆巩固过程,并简要介绍所涉及的初步的细胞和分子机制． 相似文献
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《Current biology : CB》2022,32(4):834-841.e5
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刘力 《生物化学与生物物理进展》2010,37(11):1157-1158
哺乳动物脑中的海马结构被发现已经有几个世纪了,而初步确定其功能却是近几十年神经科学领域的重大发现．目前普遍认为海马是与记忆密切相关的,并把海马作为揭示学习记忆等认知过程细胞分子基础的重要模型．就近年在《生物化学与生物物理进展》上发表的相关文章进行了评论． 相似文献
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Doyun Kim Sena Chung Seung‐Hyun Lee Se‐Young Choi Soung‐Min Kim JaeHyung Koo Jong‐Ho Lee Jeong Won Jahng 《Journal of cellular and molecular medicine》2017,21(12):3752-3760
The hypoglossal nerve controls tongue movements, and damages of it result in difficulty in mastication and food intake. Mastication has been reported to maintain hippocampus‐dependent cognitive function. This study was conducted to examine the effect of tongue motor loss on the hippocampus‐dependent cognitive function and its underlying mechanism. Male Sprague Dawley rats were subjected to the initial training of Morris water maze task before or after the bilateral transection of hypoglossal nerves (Hx). When the initial training was given before the surgery, the target quadrant dwelling time during the probe test performed at a week after the surgery was significantly reduced in Hx rats relative to sham‐operated controls. When the initial training was given after the surgery, Hx affected the initial and reversal trainings and probe tests. Brain‐derived neurotrophic factor (BDNF) expression, cell numbers and long‐term potentiation (LTP) were examined in the hippocampus on the 10th day, and BrdU and doublecortin staining on the 14th day, after the surgery. Hx decreased the hippocampal BDNF and cells in the CA1/CA3 regions and impaired LTP. BrdU and doublecortin staining was decreased in the dentate gyrus of Hx rats. Results suggest that tongue motor loss impairs hippocampus‐dependent cognitive function, and decreased BDNF expression in the hippocampus may be implicated in its underlying molecular mechanism in relation with decreased neurogenesis/proliferation and impaired LTP. 相似文献