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Maclean JA Chen MA Wayne CM Bruce SR Rao M Meistrich ML Macleod C Wilkinson MF 《Cell》2005,120(3):369-382
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Kagotani K Takebayashi S Kohda A Taguchi H Paulsen M Walter J Reik W Okumura K 《Bioscience, biotechnology, and biochemistry》2002,66(5):1046-1051
Genomic imprinting is characterized by allele-specific expression of genes within chromosomal domains. Here we show, using fluorescence in situ hybridization (FISH) analysis, that the large chromosomal domain of the mouse distal chromosome 7 imprinting cluster, approximately 1 Mb in length between p57Kip2 and H19 genes, replicates asynchronously between the two alleles during S-phase. At the telomeric side of this domain, we found a transition from asynchronous replication at the imprinted p57Kip2 gene to synchronous replication at the Nap2 gene. Two-color FISH suggested that the paternal allele of this whole domain replicates earlier than its maternal allele. Treatment of the cells with a histone deacetylase inhibitor abolished this allele-specific feature accompanied with accelerated replication of the later-replicating allele at a domain level. Allele-specific asynchronous replication was observed even in ES cells. These results suggest that this imprinting cluster consists of a large replication domain which is already found at the early stage in development. 相似文献
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Senawong T Peterson VJ Avram D Shepherd DM Frye RA Minucci S Leid M 《The Journal of biological chemistry》2003,278(44):43041-43050
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The polycomb group protein Suz12 is required for embryonic stem cell differentiation 总被引:11,自引:0,他引:11
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Pasini D Bracken AP Hansen JB Capillo M Helin K 《Molecular and cellular biology》2007,27(10):3769-3779