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赤霉素A4,A7的研究进展 总被引:7,自引:0,他引:7
赤霉素A_4、A_7的研究进展颜方贵,秦杰,何增国,李季伦(北京农业大学生物学院,北京100094)赤霉素A_3(GA_3)是目前应用最广的植物生长激素之一。随着研究的深入,对该族的其它同系物,特别是GA_4、GA_7越来越受到重视,这是由于GA_4... 相似文献
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目的研究膀胱移行细胞癌(TCC)中黑色素瘤抗原(MAGE)基因表达。方法逆转录聚合酶链反应(RT-PCR)技术检测20例膀胱TCC患者癌组织和3株膀胱TCC细胞株T24、EJ、BIU87中MAGE-A1、A2、A3、A4基因mRNA表达。结果20例膀胱TCC癌组织中19例(95%)至少表达一种MAGE-A基因,12例MAGE-A1阳性(60%),16例MAGE-A2阳性(80%),11例MAGE-A3阳性(55%),18例MAGE-A4阳性(90%),MAGE-A1-4均阳性8例(40%)。膀胱TCC细胞株T24中MAGE-A1-4基因均表达,EJ中MAGE-A3、A4基因表达,BIU87中MAGE-A2、A3、A4基因表达。结论MAGE基因在膀胱TCC中有较高表达,可望成为膀胱TCC免疫治疗的靶基因。 相似文献
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Summary This paper reports a rare malformation syndrome which is observed in two sibs (brother and sister) of a family. It consists of nearly symmetric reductive defects of the limbs, flexon contractures of various joints, cleft lip and cleft palate, multiple minor abnormalities including capillary hemangioma of the forehead, hypoplastic cartilages of ears and nose, micrognathia, intrauterine growth retardation, and possibly mental retardation. Chromosomes of both parents and propositi are normal. Genetic data suggest autosomal recessive inheritance. 相似文献
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从民间药用抗肝炎药相思子(AbrusprecatoriusL.)根中分得8个异黄烷醌类化合物,即相思子醌A、B、D、E、F、G以及已知化合物3,7二羟基6甲氧基双氢黄酮和2,8二羟基3,4,9,10四甲氧基紫檀素。用化学转化和光谱学方法包括1H1HCOSY、1H13CCOSY、CD等方法鉴定它们的结构。 相似文献
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Vibrostimulation of skin from the crus of the cat at frequencies of 10, 30, and 50/sec evokes a response of mechanoreceptors innervating group A and A fibers to the presentation of each vibrostimulus. The higher the frequency of vibrostimulation, the more clearly manifest are changes in on- and off-responses on a neurogram recorded from the n. saphenus branch. These changes are a result of a decrease in the number of impulses evoked by each vibratory beat. Mechanoreceptors innervated by fibers of group C are not excited as a result of vibrostimulation at these frequencies. After preliminary vibrostimulation, a portion of the mechanoreceptors innervated by C-fibers do not respond to presentation of a mechanical test stimulus (stretching of the skin); the higher the frequency of vibrostimulation, the smaller is the number of reacting receptors.Kirov Medical Institute, Nizhny Novgorod. Translated from Neirofiziologiya, Vol. 24, No. 1, pp. 20–27, January–February, 1992. 相似文献
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Luciano Gastaldo Romeo Ciabatti Francesco Assi Ermenegildo Restelli Jurgen K. Kettenring Luigi F. Zerilli Gabriella Romanò Maurizio Denaro Bruno Cavalleri 《Journal of industrial microbiology & biotechnology》1992,11(1):13-18
Summary WhenActinoplanes strain ATCC 33076, the producer of A-16686 A1, A2 and A3 complex, is fermented in a suitable medium three additional factors, designated A1, A2 and A3 are produced. These were isolated and characterized, and were shown to differ from the parent components of the original complex by lacking one mannose unit. Bioconversion of A factors into A factors was achieved by incubation with the mycelium ofActinoplanes ATCC 33076. Factor A2 has better antibacterial activity than A2 against some bacteria. 相似文献
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Aβ peptide is the major component of senile plaques (SP) which accumulates in AD (Alzheimer's disease) brain. Reports from different laboratories indicate that anesthetics interact with Aβ peptide and induce Aβ oligomerization. The molecular mechanism of Aβ peptide interactions with these anesthetics was not determined. We report molecular details for the interactions of uniformly 15N labeled Aβ40 with different anesthetics using 2D nuclear magnetic resonance (NMR) experiments. At high concentrations both isoflurane and propofol perturb critical amino acid residues (G29, A30 and I31) of Aβ peptide located in the hinge region leading to Aβ oligomerization. In contrast, these three specific residues do not interact with thiopental and subsequently no Aβ oligomerization was observed. However, studies with combined anesthetics (thiopental and halothane), showed perturbation of these residues (G29, A30 and I31) and subsequently Aβ oligomerization was found. Perturbation of these specific Aβ residues (G29, A30 and I31) by different anesthetics could play an important role to induce Aβ oligomerization. 相似文献
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