共查询到20条相似文献，搜索用时 0 毫秒
1.
Andrew J. Potter Stuart Ray Louisa Gueritz Claire L. Nunns Christopher J. Bryant Simon F. Scrace Natalia Matassova Lisa Baker Pawel Dokurno David A. Robinson Allan E. Surgenor Ben Davis James B. Murray Christine M. Richardson Jonathan D. Moore 《Bioorganic & medicinal chemistry letters》2010,20(16):e1
2.
3.
Silvia Serra Andrea Chicca Giovanna Delogu Saleta Vázquez-Rodríguez Lourdes Santana Eugenio Uriarte Laura Casu Jürg Gertsch 《Bioorganic & medicinal chemistry letters》2012,22(21):6775
Here we present the synthesis and antiproliferative activity of a series of diversely substituted 12 synthesized 4-oxycoumarin derivatives. Among all compounds the 4-hydroxy-5,7-dimethoxycoumarin showed the most potent antiproliferative effect against several human (MCF-7, U937 and HL-60) and mouse (Neuro2a) cancer cell lines with IC50 values in the range of 0.2–2 μM. Intriguingly its structural isomer where only methoxy group is changed from 5 to 8 position was inactive in MCF-7 cells, and only weakly active in HL-60, U937 and Neuro2a cells.
- Download : Download full-size image
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Stephen P. East Clara Bantry White Oliver Barker Stephanie Barker James Bennett David Brown E. Andrew Boyd Christopher Brennan Chandana Chowdhury Ian Collins Emmanuelle Convers-Reignier Brian W. Dymock Rowena Fletcher David J. Haydon Mihaly Gardiner Stuart Hatcher Peter Ingram Paul Lancett Paul Mortenson Konstantinos Papadopoulos Lloyd G. Czaplewski 《Bioorganic & medicinal chemistry letters》2009,19(9):2606
16.
17.
18.
19.
Alessandro A. Boezio Loren Berry Brian K. Albrecht David Bauer Steven F. Bellon Christiane Bode April Chen Deborah Choquette Isabelle Dussault Mei Fang Satoko Hirai Paula Kaplan-Lefko Jay F. Larrow Min-Hwa Jasmine Lin Julia Lohman Michele H. Potashman Yusheng Qu Karen Rex Michael Santostefano Kavita Shah Jean-Christophe Harmange 《Bioorganic & medicinal chemistry letters》2010,20(2):773