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Silvia Serra Andrea Chicca Giovanna Delogu Saleta Vázquez-Rodríguez Lourdes Santana Eugenio Uriarte Laura Casu Jürg Gertsch 《Bioorganic & medicinal chemistry letters》2012,22(21):6775
Here we present the synthesis and antiproliferative activity of a series of diversely substituted 12 synthesized 4-oxycoumarin derivatives. Among all compounds the 4-hydroxy-5,7-dimethoxycoumarin showed the most potent antiproliferative effect against several human (MCF-7, U937 and HL-60) and mouse (Neuro2a) cancer cell lines with IC50 values in the range of 0.2–2 μM. Intriguingly its structural isomer where only methoxy group is changed from 5 to 8 position was inactive in MCF-7 cells, and only weakly active in HL-60, U937 and Neuro2a cells.
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Andrew J. Potter Stuart Ray Louisa Gueritz Claire L. Nunns Christopher J. Bryant Simon F. Scrace Natalia Matassova Lisa Baker Pawel Dokurno David A. Robinson Allan E. Surgenor Ben Davis James B. Murray Christine M. Richardson Jonathan D. Moore 《Bioorganic & medicinal chemistry letters》2010,20(16):e1
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Chris A. Smethurst Nicola Bevan Carl Brooks Amanda Emmons Peter J. Gough Claudette Mookherjee Kitty Moores Simon Peace Joanne Philp Val Piercy Steve P. Watson Mara Zippoli 《Bioorganic & medicinal chemistry letters》2013,23(1):382
Optimisation of a series of biaryl sulphonamides resulted in the identification of compound 14 which demonstrated dose-dependent and strain-specific inhibition of monocyte recruitment in a thioglycollate-induced peritonitis model of inflammation.
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José M. Bueno Pilar Manzano María C. García Jesús Chicharro Margarita Puente Milagros Lorenzo Adolfo García Santiago Ferrer Rubén M. Gómez María T. Fraile José L. Lavandera José M. Fiandor Jaume Vidal Esperanza Herreros Domingo Gargallo-Viola 《Bioorganic & medicinal chemistry letters》2013,23(24):6938
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Kirk D. Robarge Shirley A. Brunton Georgette M. Castanedo Yong Cui Michael S. Dina Richard Goldsmith Stephen E. Gould Oivin Guichert Janet L. Gunzner Jason Halladay Wei Jia Cyrus Khojasteh Michael F.T. Koehler Karen Kotkow Hank La Rebecca L. LaLonde Kevin Lau Leslie Lee Derek Marshall James C. Marsters Minli Xie 《Bioorganic & medicinal chemistry letters》2010,20(2):771
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Zhijian Zhao Scott E. Wolkenberg Philip E.J. Sanderson Meiqing Lu Vandna Munshi Gregory Moyer Meizhen Feng Anthony V. Carella Linda T. Ecto Lori J. Gabryelski Ming-Tain Lai Sridar G. Prasad Youwei Yan Georgia B. McGaughey Michael D. Miller Craig W. Lindsley George D. Hartman Joseph P. Vacca Theresa M. Williams 《Bioorganic & medicinal chemistry letters》2010,20(17):5360