共查询到20条相似文献,搜索用时 15 毫秒
1.
Introduction
Although systemic autoimmune diseases (SAID) share many clinical and laboratory features, whether they also share some common features of pathogenesis remains unclear. We assessed plasma proteomic profiles among different SAID for evidence of common molecular pathways that could provide insights into pathogenic mechanisms shared by these diseases. 相似文献2.
Background
Recently, perfluorooctanoic acid (PFOA) has become a significant issue in many aspects of environmental ecology, toxicology, pathology and life sciences because it may have serious effects on the endocrine, immune and nervous systems and can lead to embryonic deformities and other diseases. Human serum albumin (HSA) is the major protein component of blood plasma and is called a multifunctional plasma carrier protein because of its ability to bind an unusually broad spectrum of ligands. 相似文献3.
Giovanni Zuliani Michela Perrone Donnorso Cristina Bosi Angelina Passaro Edoardo Dalla Nora Amedeo Zurlo Francesco Bonetti Alessia F Mozzi Claudio Cortese 《BMC neurology》2011,11(1):121
Background
In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol). Some studies suggested an association between 24S-OH-Chol metabolism and different neurological diseases including dementia. A possible decrease in 24S-OH-Chol plasma levels has been reported late onset Alzheimer's disease (LOAD) and vascular dementia (VD), but results of previous studies are partially contradictory. 相似文献4.
Robert Ehehalt Richard Sparla Hasan Kulaksiz Thomas Herrmann Joachim Füllekrug Wolfgang Stremmel 《BMC cell biology》2008,9(1):45
Background
Mechanisms of long chain fatty acid uptake across the plasma membrane are important targets in treatment of many human diseases like obesity or hepatic steatosis. Long chain fatty acid translocation is achieved by a concert of co-existing mechanisms. These lipids can passively diffuse, but certain membrane proteins can also accelerate the transport. However, we now can provide further evidence that not only proteins but also lipid microdomains play an important part in the regulation of the facilitated uptake process. 相似文献5.
Philip Stegmaier Mathias Krull Nico Voss Alexander E Kel Edgar Wingender 《BMC systems biology》2010,4(1):124
Background
The study of relationships between human diseases provides new possibilities for biomedical research. Recent achievements on human genetic diseases have stimulated interest to derive methods to identify disease associations in order to gain further insight into the network of human diseases and to predict disease genes. 相似文献6.
Marcelo H Ratto Wilfredo Huanca Gregg P Adams 《Reproductive biology and endocrinology : RB&E》2010,8(1):44
Background
Previously, we documented the presence of ovulation-inducing factor (OIF) in the seminal plasma of llamas and alpacas. The purpose of the study was to define the biochemical characteristics of the molecule(s) in seminal plasma responsible for inducing ovulation. 相似文献7.
Background
The overall objective of the Ansan Geriatric Study (AGE study) was to describe the prevalence, incidence, and related risk factors for geriatric diseases in elderly Koreans. 相似文献8.
Background
Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases. 相似文献9.
Marco Candela Clarissa Consolandi Marco Severgnini Elena Biagi Bianca Castiglioni Beatrice Vitali Gianluca De Bellis Patrizia Brigidi 《BMC microbiology》2010,10(1):116
Background
Affecting the core functional microbiome, peculiar high level taxonomic unbalances of the human intestinal microbiota have been recently associated with specific diseases, such as obesity, inflammatory bowel diseases, and intestinal inflammation. 相似文献10.
Ghazi Chabchoub Elif Uz Abdellatif Maalej Chigdem A Mustafa Ahmed Rebai Mouna Mnif Zouheir Bahloul Nadir R Farid Tayfun Ozcelik Hammadi Ayadi 《Arthritis research & therapy》2009,11(4):R106-8
Introduction
The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases. 相似文献11.
Marcelo H Ratto Louis TJ Delbaere Yvonne A Leduc Roger A Pierson Gregg P Adams 《Reproductive biology and endocrinology : RB&E》2011,9(1):24
Background
The objective of the present study was to isolate and purify the protein fraction(s) of llama seminal plasma responsible for the ovulation-inducing effect of the ejaculate. 相似文献12.
Johannes HM Levels Boris Bleijlevens Farhad Rezaee Johannes MFG Aerts Joost CM Meijers 《Proteome science》2007,5(1):15-8
Background
High-Density Lipoprotein (HDL), one of the main plasma lipoproteins, serves as a docking station for proteins involved in inflammation, coagulation, and lipid metabolism. 相似文献13.
Background
Realistic modeling of cardiac inter-beat (RR) intervals is highly desirable for basic research in cardiac electrophysiology, clinical management of heart diseases, and developing signal processing tools for ECG analysis. 相似文献14.
Karen M Moody Lawrence B Schonberger Ryan A Maddox Wen-Quan Zou Laura Cracco Ignazio Cali 《BMC neurology》2011,11(1):136
Background
Sporadic fatal insomnia (sFI) and fatal familial insomnia (FFI) are rare human prion diseases. 相似文献15.
Teschendorff AE Naderi A Barbosa-Morais NL Pinder SE Ellis IO Aparicio S Brenton JD Caldas C 《Genome biology》2006,7(10):R101-13
Background
A consensus prognostic gene expression classifier is still elusive in heterogeneous diseases such as breast cancer. 相似文献16.
Background
The morphological changes of the retinal blood vessels in retinal images are important indicators for diseases like diabetes, hypertension and glaucoma. Thus the accurate segmentation of blood vessel is of diagnostic value. 相似文献17.
Keith Al-Hasani John Boyce Victoria P McCarl Stephen Bottomley Ian Wilkie Ben Adler 《Microbial cell factories》2007,6(1):3
P. multocida is a Gram-negative pathogen responsible for causing diseases in animals of economic significance to livestock industries throughout the world. Current vaccines include bacterins, which provide only limited protection against homologous serotypes. Therefore there is a need for more effective vaccines to control diseases caused by P. multocida. As a step towards developing vaccines against fowl cholera, a genomics based approach was applied for the identification of novel immunogens. 相似文献
18.
Shaw-Wei D Tsen Chao-Yi Wu Avedis Meneshian Sara I Pai Chien-Fu Hung T-C Wu 《Journal of biomedical science》2009,16(1):36-7
Background
Gene therapy with plasmid DNA is emerging as a promising strategy for the treatment of many diseases. One of the major obstacles to such therapy is the poor transfection efficiency of DNA in vivo. 相似文献19.
Background
In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure and intact Plasmodium falciparum plasma membrane would provide a suitable model to elucidate the possible role played by the parasite plasma membrane in ion balance and drug transport. 相似文献20.