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1.
In recent years, there has been increasing interest in research on geographical variation in the incidence of schizophrenia and other psychoses. In this paper, we review the evidence on variation in incidence of schizophrenia and other psychoses in terms of place, as well as the individual‐ and area‐level factors that account for this variation. We further review findings on potential mechanisms that link adverse urban environment and psychosis. There is evidence from earlier and more recent studies that urbanicity is associated with an increased incidence of schizophrenia and non‐affective psychosis. In addition, considerable variation in incidence across neighbourhoods has been observed for these disorders. Findings suggest it is unlikely that social drift alone can fully account for geographical variation in incidence. Evidence further suggests that the impact of adverse social contexts – indexed by area‐level exposures such as population density, social fragmentation and deprivation – on risk of psychosis is explained (confounding) or modified (interaction) by environmental exposures at the individual level (i.e., cannabis use, social adversity, exclusion and discrimination). On a neurobiological level, several studies suggest a close link between social adversity, isolation and stress on the one hand, and monoamine dysfunction on the other, which resembles findings in schizophrenia patients. However, studies directly assessing correlations between urban stress or discrimination and neurobiological alterations in schizophrenia are lacking to date. 相似文献
2.
Cognitive impairment in schizophrenia involves a broad array of nonsocial and social cognitive domains. It is a core feature of the illness, and one with substantial implications for treatment and prognosis. Our understanding of the causes, consequences and interventions for cognitive impairment in schizophrenia has grown substantially in recent years. Here we review a range of topics, including: a) the types of nonsocial cognitive, social cognitive, and perceptual deficits in schizophrenia; b) how deficits in schizophrenia are similar or different from those in other disorders; c) cognitive impairments in the prodromal period and over the lifespan in schizophrenia; d) neuroimaging of the neural substrates of nonsocial and social cognition, and e) relationships of nonsocial and social cognition to functional outcome. The paper also reviews the considerable efforts that have been directed to improve cognitive impairments in schizophrenia through novel psychopharmacology, cognitive remediation, social cognitive training, and alternative approaches. In the final section, we consider areas that are emerging and have the potential to provide future insights, including the interface of motivation and cognition, the influence of childhood adversity, metacognition, the role of neuroinflammation, computational modelling, the application of remote digital technology, and novel methods to evaluate brain network organization. The study of cognitive impairment has provided a way to approach, examine and comprehend a wide range of features of schizophrenia, and it may ultimately affect how we define and diagnose this complex disorder. 相似文献
3.
Dova B. Brenman‐Suttner Ryley T. Yost Ariel K. Frame J. Wesley Robinson Amanda J. Moehring Anne F. Simon 《Genes, Brain & Behavior》2020,19(2)
The field of behavioral genetics has recently begun to explore the effect of age on social behaviors. Such studies are particularly important, as certain neuropsychiatric disorders with abnormal social interactions, like autism and schizophrenia, have been linked to older parents. Appropriate social interaction can also have a positive impact on longevity, and is associated with successful aging in humans. Currently, there are few genetic models for understanding the effect of aging on social behavior and its potential transgenerational inheritance. The fly is emerging as a powerful model for identifying the basic molecular mechanisms underlying neurological and neuropsychiatric disorders. In this review, we discuss these recent advancements, with a focus on how studies in Drosophila melanogaster have provided insight into the effect of aging on aspects of social behavior, including across generations. 相似文献
4.
Abnormal phospholipid metabolism has been implicated in the pathogenesis of schizophrenia, and it was reported that phospholipase C (PLC) β1 is reduced in specific brain areas of patients with schizophrenia. However, the causal relationship of the PLCβ1 gene with behavioral symptoms of schizophrenia remains unclear. To address this issue, we have examined the mutant mice lacking PLCβ1 for schizophrenia-related phenotypes by performing various behavioral tests, including general locomotor activity, sensorimotor gating, social behaviors, and learning and memory. Phospholipase C β1 knockout mice showed hyperactivities in an open field. They showed impaired prepulse inhibition of acoustic startle response, which was ameliorated by a systemic administration of an antipsychotic D2-receptor antagonist, haloperidol. In addition, they showed abnormal social behaviors, such as lack of barbering behavior, socially recessive trait and lack of nesting behavior. Furthermore, they showed impaired performance in the delayed-non-match-to-sample T-maze test. The present results show that the PLCβ1 mutant mice share some of the behavioral abnormalities that have been reported in patients with schizophrenia. Thus, the PLCβ1-linked signaling pathways may be involved in the neural system whose function is disrupted in the pathogenesis of schizophrenia. 相似文献
5.
Background
An increasing body of evidence suggests that the apparent social impairments observed in schizophrenia may arise from deficits in social cognitive processing capacities. The ability to process basic social cues, such as gaze direction and biological motion, effortlessly and implicitly is thought to be a prerequisite for establishing successful social interactions and for construing a sense of “social intuition.” However, studies that address the ability to effortlessly process basic social cues in schizophrenia are lacking. Because social cognitive processing deficits may be part of the genetic vulnerability for schizophrenia, we also investigated two groups that have been shown to be at increased risk of developing schizophrenia-spectrum pathology: first-degree relatives of schizophrenia patients and men with Klinefelter syndrome (47,XXY).Results
We compared 28 patients with schizophrenia, 29 siblings of patients with schizophrenia, and 29 individuals with Klinefelter syndrome with 46 matched healthy control subjects on a new paradigm. This paradigm measures one''s susceptibility for a bias in distance estimation between two agents that is induced by the implicit processing of gaze direction and biological motion conveyed by these agents. Compared to control subjects, patients with schizophrenia, as well as siblings of patients and Klinefelter men, showed a lack of influence of social cues on their distance judgments.Conclusions
We suggest that the insensitivity for social cues is a cognitive aspect of schizophrenia that may be seen as an endophenotype as it appears to be present both in relatives who are at increased genetic risk and in a genetic disorder at risk for schizophrenia-spectrum psychopathology. These social cue–processing deficits could contribute, in part, to the difficulties in higher order social cognitive tasks and, hence, to decreased social competence that has been observed in these groups. 相似文献6.
Pathogens have likely infl uenced life-history evolution in social insects because their nesting ecology and sociality can
exacerbate the risk of disease transmission and place demands on the immune system that ultimately can impact colony survival
and growth. The costs of the maintenance and induction of immune function may be particularly significant in termites, which
have a nitrogen-poor diet. We examined the effect of fungal exposure on survival and reproduction during colony foundation
in the dampwood termite Zootermopsis angusticollis by experimentally pairing male and female primary reproductives and exposing them to single (‘acute’) and multiple (‘serial’)
dosages of conidia of the fungus Metarhizium anisopliae and recording their survival and fitness over a 560 day period. The
number of eggs laid 70 days post-pairing was significantly reduced relative to controls in the serial-exposure but not the
acute-exposure treatment. Reproduction thus appeared to be more resilient to a single pathogen exposure than to serial challenge
to the immune system. The impact of fungal exposure was transient: all surviving colonies had similar reproductive output
after 300 days post-pairing. Our results suggest that disease can have significant survival and fitness costs during the critical
phase of colony foundation but that infection at this time may not necessarily impact long-term colony growth.
Received 25 February 2005; revised 27 September and 20 October 2005; accepted 20 December 2005. 相似文献
7.
K. V. Sandhu D. Lang B. Müller S. Nullmeier Y. Yanagawa H. Schwegler O. Stork 《Genes, Brain & Behavior》2014,13(4):439-450
Reduced glutamic acid decarboxylase (GAD)67 expression may be causally involved in the development of social withdrawal in neuropsychiatric states such as autism, schizophrenia and bipolar disorder. In this study, we report disturbance of social behavior in male GAD67 haplodeficient mice. GAD67+/? mice, compared to GAD67+/+ littermates, show reduced sociability and decreased intermale aggression, but normal nest building and urine marking behavior, as well as unchanged locomotor activity and anxiety‐like behavior. Moreover, the mutants display a reduced sensitivity to both social and non‐social odors, indicating a disturbance in the detection and/or processing of socially relevant olfactory stimuli. Indeed, we observed reduced activation of the lateral septum, medial preoptic area, bed nucleus of the stria terminalis, medial and cortical amygdala upon exposure of GAD67+/? mice to social interaction paradigm, as indicated by c‐Fos immunohistochemistry. These data suggest a disturbance of stimulus processing in the brain circuitry controlling social behavior in GAD67+/? mice, which may provide a useful model for studying the impact of a reduced GAD67 expression on alterations of social behavior related to neuropsychiatric disorders . 相似文献
8.
Roger Krohn 《Biology & philosophy》1991,6(2):181-203
This paper raises the question of the prominence and use of statistical graphs in science, and argues that their use in problem
solving analysis can best be understood in an ‘interactionist’ frame of analysis, including bio-emotion, culture, social organization,
and environment as elements. The frame contrasts both with philosophical realism and with social constructivism, which posit
two variables and one way causal flows. We next posit basic differences between visual, verbal, and numerical media of perception
and communication. Graphs are thus seen as key interactive sites where different media are transformed into more interpretable
forms. Examples are taken from Limnology where numbers are transformed into graphs to find patterns in them, and thus, by
implication in the environmental materials from which the numerical measurements were taken. Their revisualization by passes
a human cognitive limitation, for the direct analysis — interpretation of lists and tables of numbers, visual imaging being
a cognitive strength. Sense of problem, conceptual repertoire, and social relations are seen to direct this pattern search
and interpretive process. 相似文献
9.
Gozes I 《Peptides》2011,32(2):428-431
NAP (davunetide) is an active fragment of activity-dependent neuroprotective protein (ADNP). ADNP and the homologous protein ADNP2 provide cell protection. ADNP is essential for brain formation, proper development and neuronal plasticity, all reported to be impaired in schizophrenia. ADNP haploinsufficiecy inhibits social and cognitive functions, major hallmarks in schizophrenia. Imbalance in ADNP/ADNP2 expression in the schizophrenia brain may impact disease progression. NAP treatment partly ameliorates ADNP haploinsufficiecy. The microtubule, stable tubule-only polypeptide (STOP)-deficient mice were shown to provide a reliable model for schizophrenia. Daily intranasal NAP treatment significantly decreased hyperactivity in STOP-deficient mice and protected visual memory, supporting further clinical development. 相似文献
10.
The snare web is used as a medium for communication betweenindividuals within colonies of social spiders and has thereforebeen suggested as necessary for the evolution of sociality inthe Araneae. The social spider Diaea socialis (Thomisidae) isan exception because it does not build a snare web. Experimentsdemonstrate that silk attracts all spiders and that a chemicaldeposited onto the silk attracts adult female spiders, suggestingthat the group living of this species is mediated by a pheromone.The pheromone attracts spiders differentially: females are notattracted to juvenile silk, and it repels gravid females. Thepheromone appears to be stable but volatile, is ether-soluble,and retains its viability after dissolution. Molecular-ionicmasses for 7-8 different compounds were found in the range 220281atomic units; the pheromone may be one or a combination of severalof these. 相似文献
11.
Joseph Firth John Torous Brendon Stubbs Josh A. Firth Genevieve Z. Steiner Lee Smith Mario Alvarez‐Jimenez John Gleeson Davy Vancampfort Christopher J. Armitage Jerome Sarris 《World psychiatry》2019,18(2):119-129
The impact of the Internet across multiple aspects of modern society is clear. However, the influence that it may have on our brain structure and functioning remains a central topic of investigation. Here we draw on recent psychological, psychiatric and neuroimaging findings to examine several key hypotheses on how the Internet may be changing our cognition. Specifically, we explore how unique features of the online world may be influencing: a) attentional capacities, as the constantly evolving stream of online information encourages our divided attention across multiple media sources, at the expense of sustained concentration; b) memory processes, as this vast and ubiquitous source of online information begins to shift the way we retrieve, store, and even value knowledge; and c) social cognition, as the ability for online social settings to resemble and evoke real‐world social processes creates a new interplay between the Internet and our social lives, including our self‐concepts and self‐esteem. Overall, the available evidence indicates that the Internet can produce both acute and sustained alterations in each of these areas of cognition, which may be reflected in changes in the brain. However, an emerging priority for future research is to determine the effects of extensive online media usage on cognitive development in youth, and examine how this may differ from cognitive outcomes and brain impact of uses of Internet in the elderly. We conclude by proposing how Internet research could be integrated into broader research settings to study how this unprecedented new facet of society can affect our cognition and the brain across the life course. 相似文献
12.
13.
A new interpretation of the social organization and mating system of the Callitrichidae 总被引:1,自引:0,他引:1
Tamarins and marmosets are usually described as monogamous, or as living in extended family groups. Field research on a variety
of callitrichid species shows, however, that immigration and emigration by adults are common and that groups are likely to
be composed largely of unrelated adults of both sexes. Despite the number of adult females present in a group, only a single
female is usually reproductively active. This female may mate with more than one male. Care for the young is provided by all
group members but principally by adult males. This generally is referred to as a “communal breeding system. ” However, a vertebrate
social system in which more than two reproductively active adults participate in infant care is rare and has otherwise been
reported only in a small number of avian and canid species. Wild callitrichid groups virtually always include helpers, but
the number of adults of each sex is highly variable. We propose that the Callitrichidae tend to live in small multimalemultifemale
groups, communally rear the young of one female, and exhibit a mating pattern characterized by female promiscuity but a breeding
system that is functionally polyandrous. There is a significant correlation between the number of males and a group and the
total number of surviving young. The possible adaptive advantages of this social organization are discussed.
An erratum to this article is available at . 相似文献
14.
Varlet M Marin L Raffard S Schmidt RC Capdevielle D Boulenger JP Del-Monte J Bardy BG 《PloS one》2012,7(1):e29772
It has been demonstrated that motor coordination of interacting people plays a crucial role in the success of social exchanges. Abnormal movements have been reported during interpersonal interactions of patients suffering from schizophrenia and a motor coordination breakdown could explain this social interaction deficit, which is one of the main and earliest features of the illness. Using the dynamical systems framework, the goal of the current study was (i) to investigate whether social motor coordination is impaired in schizophrenia and (ii) to determine the underlying perceptual or cognitive processes that may be affected. We examined intentional and unintentional social motor coordination in participants oscillating hand-held pendulums from the wrist. The control group consisted of twenty healthy participant pairs while the experimental group consisted of twenty participant pairs that included one participant suffering from schizophrenia. The results showed that unintentional social motor coordination was preserved while intentional social motor coordination was impaired. In intentional coordination, the schizophrenia group displayed coordination patterns that had lower stability and in which the patient never led the coordination. A coupled oscillator model suggests that the schizophrenia group coordination pattern was due to a decrease in the amount of available information together with a delay in information transmission. Our study thus identified relational motor signatures of schizophrenia and opens new perspectives for detecting the illness and improving social interactions of patients. 相似文献
15.
Aino Saarinen Saara Marttila Pashupati P. Mishra Leo-Pekka Lyytikäinen Emma Raitoharju Nina Mononen Elina Sormunen Mika Kähönen Olli Raitakari Jarmo Hietala Liisa Keltikangas-Järvinen Terho Lehtimäki 《Aging cell》2024,23(3):e14052
Schizophrenia is often regarded as a disorder of premature aging. We investigated (a) whether polygenic risk for schizophrenia (PRSsch) relates to pace of epigenetic aging and (b) whether personal dispositions toward active and emotionally close relationships protect against accelerated epigenetic aging in individuals with high PRSsch. The sample came from the population-based Young Finns Study (n = 1348). Epigenetic aging was measured with DNA methylation aging algorithms such as AgeAccelHannum, EEAAHannum, IEAAHannum, IEAAHorvath, AgeAccelHorvath, AgeAccelPheno, AgeAccelGrim, and DunedinPACE. A PRSsch was calculated using summary statistics from the most comprehensive genome-wide association study of schizophrenia to date. Social dispositions were assessed in terms of extraversion, sociability, reward dependence, cooperativeness, and attachment security. We found that PRSsch did not have a statistically significant effect on any studied indicator of epigenetic aging. Instead, PRSsch had a significant interaction with reward dependence (p = 0.001–0.004), cooperation (p = 0.009–0.020), extraversion (p = 0.019–0.041), sociability (p = 0.003–0.016), and attachment security (p = 0.007–0.014) in predicting AgeAccelHannum, EEAAHannum, or IEAAHannum. Specifically, participants with high PRSsch appeared to display accelerated epigenetic aging at higher (vs. lower) levels of extraversion, sociability, attachment security, reward dependence, and cooperativeness. A rather opposite pattern was evident for those with low PRSsch. No such interactions were evident when predicting the other indicators of epigenetic aging. In conclusion, against our hypothesis, frequent social interactions may relate to accelerated epigenetic aging in individuals at risk for psychosis. We speculate that this may be explained by social-cognitive impairments (perceiving social situations as overwhelming or excessively arousing) or ending up in less supportive or deviant social groups. 相似文献
16.
Emily S. Cross Richard Ramsey Roman Liepelt Wolfgang Prinz Antonia F. de C. Hamilton 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2016,371(1686)
Although robots are becoming an ever-growing presence in society, we do not hold the same expectations for robots as we do for humans, nor do we treat them the same. As such, the ability to recognize cues to human animacy is fundamental for guiding social interactions. We review literature that demonstrates cortical networks associated with person perception, action observation and mentalizing are sensitive to human animacy information. In addition, we show that most prior research has explored stimulus properties of artificial agents (humanness of appearance or motion), with less investigation into knowledge cues (whether an agent is believed to have human or artificial origins). Therefore, currently little is known about the relationship between stimulus and knowledge cues to human animacy in terms of cognitive and brain mechanisms. Using fMRI, an elaborate belief manipulation, and human and robot avatars, we found that knowledge cues to human animacy modulate engagement of person perception and mentalizing networks, while stimulus cues to human animacy had less impact on social brain networks. These findings demonstrate that self–other similarities are not only grounded in physical features but are also shaped by prior knowledge. More broadly, as artificial agents fulfil increasingly social roles, a challenge for roboticists will be to manage the impact of pre-conceived beliefs while optimizing human-like design. 相似文献
17.
Maud Poisbleau Matthieu Guillemain Laurent Demongin David Carslake Joan David 《Journal of Ornithology》2009,150(1):195-204
Juveniles of many birds establish dominance hierarchies within family social units, only to leave and compete to acquire dominance
status in new social groups. Little is known about the role of sex, body mass, size or experience during the duckling period
on subsequent dominance rank and adult social relationships. We used captive Mallard Anas platyrhynchos ducklings to test for the role of individual characteristics and growth parameters in establishing within-brood hierarchies,
the maintenance of within-brood hierarchies in the subsequent wintering group and differences in social ranks between broods.
Strong stable linear hierarchies were present within each brood and, later, within each phase of the winter. There was a reorganisation
of the hierarchical order between the duckling period and early winter, but only few modifications afterwards during the winter.
None of the tested “hatching”, “duckling” and “adult” traits explained either the within-brood or the winter hierarchies,
but winter rank was related to brood of origin with ducklings from the same brood having similar social ranks. These differences
between broods were maintained through the whole winter in most cases, though one brood drastically progressed in the hierarchy
during late-winter. These results suggest that the factors affecting the establishment of social relationships within broods
differ from those in winter groups, and that brood-related mechanisms influence social relationships during winter. We discuss
our results in the light of direct and indirect maternal influence. 相似文献
18.
Roni G. Alder Jennifer L. Young Elizabeth I. Russell Danielle R. McHardy Richard J. Linscott 《PloS one》2013,8(4)
In studies of schizotypy, investigators seldom inform participants that they are engaged in research designed to shed light on risk for schizophrenia. Such nondisclosure is justified in part by the argument that disclosure of risk status may be harmful. However, there is little evidence that this is the case. Harm arising from disclosure of risk status was examined in two experiments. In the first, participants (n = 114 psychology undergraduates) were asked to anticipate their reactions to news of risk for schizophrenia, depression, cancer, and diabetes, and also to indicate whether they would want to know their schizophrenia risk status. Participants anticipated schizophrenia risk would have a negative impact that was significantly greater than depression or diabetes risk but similar to cancer risk. The anticipated impact of schizophrenia risk was predicted by expectations of stigmatization as well as confidence in the accuracy of biological screening. Although 81% indicated a preference for knowing their risk status, just 11% were prepared to undergo an assessment to find out. In the second, a between-subjects deception paradigm was used to inform participants (n = 144 psychology undergraduates) they had an enzyme deficiency that placed them at increased risk for schizophrenia, cancer, or depression. Impact was assessed using prospective self-report and salivary cortisol and retrospective self-report. Impact was modeled using measures of stigmatization and health locus of control. Retrospectively, schizophrenia, cancer, and depression risk had strong negative impacts relative to a control group, but there was no effect on prospective measures. Together, the findings suggest that news of risk for schizophrenia has the potential to engender distress, although participants’ anticipations and reflections of responses are not corroborated in prospectively measured outcomes. 相似文献
19.
社会神经科学是研究人类的社会行为及其神经机制的综合性学科.从1992年学科成立至今,社会神经科学研究取得了丰硕的成果.本文系统介绍了该领域4个主要研究方向:社会知觉、社会认知、社会调节和社会互动的研究成果,并在此基础上总结了各研究方向的核心问题,即社会知觉加工的模块化问题、人类社会认知的独特性问题和社会调节加工的跨文化一致性问题.已有研究表明,社会知觉加工至少在计算算法层面是特异化的;心智化系统是人类独有的加工模块;人类社会调节不具备跨文化的一致性;大脑间耦合可能是社会互动共有的神经机制.最后,展望了社会神经科学未来的发展方向. 相似文献
20.
Emily R. Boeving Michelle A. Rodrigues Eliza L. Nelson 《American journal of primatology》2020,82(11):e23182
The emerging field of network science has demonstrated that an individual's connectedness within their social network has cascading effects to other dimensions of life. Like humans, spider monkeys live in societies with high fission–fusion dynamics, and are remarkably social. Social network analysis (SNA) is a powerful tool for quantifying connections that may vary as a function of initiating or receiving social behaviors, which has been described as shifting social roles. In primatology, the SNA literature is dominated by work in catarrhines, and has yet to be applied to the study of development in a platyrrhine model. Here, SNA was utilized in combination with R-Index social role calculation to characterize social interaction patterns in juvenile and adult Colombian spider monkeys (Ateles fusciceps rufiventris). Connections were examined across five behaviors: embrace, face-embrace, grooming, agonism, and tail-wrapping from 186 hr of observation and four network metrics. Mann–Whitney U tests were utilized to determine differences between adult and juvenile social network patterns for each behavior. Face-embrace emerged as the behavior with different network patterns for adults and juveniles for every network metric. With regard to social role, juveniles were receivers, not initiators, for embrace, face-embrace, and grooming (ps < .05). Network and social role differences are discussed in light of social development and aspects of the different behaviors. 相似文献