共查询到20条相似文献,搜索用时 31 毫秒
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A Ito 《Japanese journal of medical science & biology》1970,23(1):21-30
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P. aeruginosa adsorbed toxoid has been obtained. The stabilization of exotoxins and the content of proteases, hemolysin, lecithinase in their structure have been found to enhance the immunogenic potency of preparations which protect test animals from death caused by the experimental injections of toxins, homologous and heterologous to bacterial strains of different O-serogroups, into these animals. Antibodies neutralizing the lethal action of P. aeruginosa exotoxin have been detected in the blood sera of immunized animals. 相似文献
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用超滤、硫酸铵二段盐析法取代等电点沉淀法后,精制破伤风类毒素(精破类)的纯度由807Lf/mgPN提高到1883Lf/mgPN,纯度提高一倍以上。使用双胨培养基取代酪素培养基后,产毒水平由47Lf/ml提高到88Lf/ml(t=6.46,p<0.001);用新法精制后,精破类纯度分别为1949Lf/mgPN及1785Lf/mgPN(t=0.334,p>0.05),引用双胨培养基后可提高产毒水平,但不影响精破类的纯度。 相似文献
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The immunopurification of tetanus toxoid 总被引:1,自引:0,他引:1
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Reversion of toxicity of tetanus toxoid 总被引:1,自引:0,他引:1
K Akama A Ito A Yamamoto S Sadahiro 《Japanese journal of medical science & biology》1971,24(3):181-183
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Reversion of toxicity of diphtheria toxoid 总被引:2,自引:0,他引:2
K Akama S Kameyama S Otani S Sadahiro R Murata 《Japanese journal of medical science & biology》1971,24(3):183-187
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百日咳、白喉、破伤风、乙型肝炎联合疫苗的实验研究 总被引:2,自引:1,他引:1
对制备无细胞百日咳菌苗、白喉、破伤风、乙型肝炎联合疫苗的实验室条件进行了初步探索,实验结果表明,联合疫苗的配方以每毫升无细胞百日咳组分15-18μg.PN、白喉类毒素30lf、破伤风类毒素7-10lf和基因工程乙肝表面抗原20μg为宜,稀释缓冲液选用0.85%NaCl溶液吸附效果较好,动物实验证明联合疫苗中各组分均安全有效。 相似文献
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P A Nielsen 《Applied microbiology》1967,15(2):453-454
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Antigenicity of Clostridium botulinum type-E formol toxoid 总被引:1,自引:0,他引:1
H Kondo S Kondo R Murata G Sakaguchi 《Japanese journal of medical science & biology》1969,22(2):75-85