Antiviral action of carminomycin and some of its derivatives]

Carminomycin was shown to inhibit the development of both the DNA-containing variolovaccine virus and the RNA-containing grippe virus in chick embryos. Comparison of the effects of rubomycin, carminomycin, 14-oxy-carminomycin and carminomycin complex with bovine serum albumin in experiments with chick embryos showed that the inhibitory effect of carminomycin and its derivatives on the development of the grippe virus was much higher than that of rubomycin. The carminomycin derivatives proved to be much more active in this respect than the initial antibiotic. Carminomycin and its derivatives had a therapeutic effect on mice with experimental grippe pneumonia also on their oral use.     

On the mechanism of the biological action of some nitrophenols

The pH dependence of the germinative capacity inhibition by 14 nitrophenol derivatives was estimated on the conidia ofNeurospora sitophila. The improtance of maintaining accurate pH during biological tests, particularly with derivatives possessing a low pK value is emphasized. The McGowan relationship cannot be applied to the group of substances investigated here. No relationship could be established between the biological activity and lipid solubility. The effect of acidity of the medium and pK of fungicides on the course of absorption of phenols byNeurospora sitophila spores was studied.     

High-pressure liquid chromatography of polycyclic aromatic hydrocarbons and some of their derivatives.

The separation of polycyclic aromatic hydrocarbons and their derivatives by means of high-pressure liquid chromatography on Permaphase ODS is described. The method consists of the (isocratic) elution of compounds from the column with a methanol-water mixture of constant composition and is particularly suited to the identification of metabolic products of polycyclic hydrocarbons.