共查询到20条相似文献,搜索用时 343 毫秒
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Characterization of a MEN1 ortholog from Drosophila melanogaster 总被引:2,自引:0,他引:2
Guru SC Prasad NB Shin EJ Hemavathy K Lu J Ip YT Agarwal SK Marx SJ Spiegel AM Collins FS Oliver B Chandrasekharappa SC 《Gene》2001,263(1-2):31-38
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Padilla O Calvo J Vilà JM Arman M Gimferrer I Places L Arias MT Pujana MA Vives J Lozano F 《Immunogenetics》2000,51(12):993-1001
CD5 is a member of the family of receptors which contain extracellular domains homologous to the type I macrophage scavenger receptor cysteine-rich (SRCR) domain. Here, we compare the exon/intron organization of the human CD5 gene with its mouse homologue, as well as with the human CD6 gene, the closest related member of the SRCR superfamily. The human CD5 gene spans about 24.5 kb and consists of at least 11 exons. These exons are conserved in size, number, and structure in the mouse CD5 homologue. No evidence for the biallelic polymorphism reported in the mouse could be found among a population of 100 individuals of different ethnic origins. The human CD5 gene maps to the Chromosome (Chr) 11q12.2 region, 82 kb downstream from the human CD6 gene, in a head-to-tail orientation, a situation which recalls that reported at mouse Chr 19. The exon/intron organization of the human CD5 and CD6 genes was very similar, differing in the size of intron 1 and the number of exons coding for their cytoplasmic regions. While several isoforms, resulting from alternative splicing of the cytoplasmic exons, have been reported for CD6, we only found evidence of a cytoplasmic tailless CD5 isoform. The conserved structure of the CD5 and CD6 loci, both in mouse and human genomes, supports the notion that the two genes may have evolved from duplication of a primordial gene. The existence of a gene complex for the SRCR superfamily on human Chr 11q (and mouse Chr 19) still remains to be disclosed. 相似文献
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Kerstin Hasenpusch-Theil Brian P. Chadwick Thomas Theil Stephanie K. Heath David G. Wilkinson Anna-Marie Frischauf 《Mammalian genome》1999,10(3):294-298
We have isolated and characterized a novel PHD finger gene, PHF2, which maps to human Chromosome (Chr) 9q22 close to D9S196.
Its mouse homolog was also characterized and mapped to the syntenic region on mouse Chr 13. The predicted human and mouse
proteins are 98% identical and contain a PHD finger domain, eight possible nuclear localization signals, two potential PEST
sequences, and a novel conserved hydrophobic domain. Northern analysis shows widespread expression of PHF2 in adult tissues,
while in situ hybridization on mouse embryos reveals staining in the neural tube and dorsal root ganglia significantly above
a ubiquitous low level expression signal. From its expression pattern and its chromosomal localization, PHF2 is a candidate
gene for hereditary sensory neuropathy type I, HSN1.
Received: 9 July 1998 / Accepted: 16 October 1998 相似文献
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Akihira Ohtoshi Ichiko Nishijima Monica J Justice Richard R Behringer 《Mechanisms of development》2002,110(1-2):241-244
To identify novel homeobox genes expressed during mouse embryogenesis, we searched the databases and found a novel mouse paired-like homeobox gene, Dmbx1(diencephalon/mesencephalon-expressed brain homeobox gene 1), that is also conserved in zebrafish and human. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4 that is the homologous gene cluster region of human chromosome 1, where human DMBX1 is located. Both mouse and human Dmbx1/DMBX1 have four coding exons and their gene structures are conserved. Whole-mount in situ hybridization revealed that Dmbx1 expression is detected in 7.5-9.5 dpc mouse embryos. At 7.5 and 8.5 dpc, Dmbx1 is expressed in a sub-region of the anterior head folds. At 9.5 dpc, expression is observed in the caudal diencephalon as well as in the mesencephalon and is restricted to the neuroepithelium. Expression in adult tissues was detected in brain, stomach, and testis. Dmbx1 provides a unique marker of the developing anterior nervous system and should provide a useful molecular resource to elucidate the mechanisms that pattern the vertebrate brain. 相似文献
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