共查询到20条相似文献,搜索用时 15 毫秒
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A role for caspases in controlling IL-4 expression in T cells 总被引:3,自引:0,他引:3
Sehra S Patel D Kusam S Wang ZY Chang CH Dent AL 《Journal of immunology (Baltimore, Md. : 1950)》2005,174(6):3440-3446
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Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells. 总被引:8,自引:0,他引:8
P G Soro P Morales-A J A Martínez-M S Morales-A S G Copín M A Marcos M L Gaspar 《Journal of immunology (Baltimore, Md. : 1950)》1999,163(2):611-617
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IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression 总被引:3,自引:0,他引:3
Suto A Wurster AL Reiner SL Grusby MJ 《Journal of immunology (Baltimore, Md. : 1950)》2006,177(6):3721-3727
Exposure of naive Th cell precursors (Thp) to IL-21 inhibits IFN-gamma production from developing Th1 cells. The inhibition of IFN-gamma seen in IL-21-treated Thp cells is specific as the expression of other Th1 cytokines is unaffected. Recently, it has been reported that Eomesodermin (Eomes), a member of the T-box gene family, is expressed in developing CD8+ T cells and plays an important role in regulating IFN-gamma production and cytolytic effector function. In this study, we show that Eomes mRNA and protein are also expressed in developing Th1 cells, and exposure of naive Thp cells to IL-21 results in a decrease in Eomes expression. Moreover, the repression of Eomes expression by IL-21 is not due to an indirect effect of IL-21 on the expression of IFN-gamma or STAT4 and is independent of STAT1 and T-bet expression. Finally, we show that ectopic expression of Eomes prevents the inhibition of IFN-gamma production from IL-21-treated Thp cells. Taken together, these results demonstrate that Eomes plays a role in regulating IFN-gamma production in CD4+ T cells and IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomes expression. 相似文献
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Willinger T Freeman T Herbert M Hasegawa H McMichael AJ Callan MF 《Journal of immunology (Baltimore, Md. : 1950)》2006,176(3):1439-1446
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Owaki T Asakawa M Morishima N Mizoguchi I Fukai F Takeda K Mizuguchi J Yoshimoto T 《Journal of immunology (Baltimore, Md. : 1950)》2008,180(5):2903-2911
IL-27, a member of the IL-6/IL-12 family, activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130 subunits, resulting in augmentation of Th1 differentiation and suppression of proinflammatory cytokine production. In the present study, we investigated the role of STAT3 in the IL-27-mediated immune functions. IL-27 induced phosphorylation of STAT1, -2, -3 and -5 in wild-type naive CD4+ T cells, but failed to induce that of STAT3 and STAT5 in STAT3-deficient cohorts. IL-27 induced not only proinflammatory responses including up-regulation of ICAM-1, T-box expressed in T cells, and IL-12Rbeta2 and Th1 differentiation, but also anti-inflammatory responses including suppression of proinflammatory cytokine production such as IL-2, IL-4, and IL-13 even in STAT3-deficient naive CD4+ T cells. In contrast, IL-27 augmented c-Myc and Pim-1 expression and induced cell proliferation in wild-type naive CD4+ T cells but not in STAT3-deficient cohorts. Moreover, IL-27 failed to activate STAT3, augment c-Myc and Pim-1 expression, and induce cell proliferation in pro-B BaF/3 transfectants expressing mutant gp130, in which the putative STAT3-binding four Tyr residues in the YXXQ motif of the cytoplasmic region was replaced by Phe. These results suggest that STAT3 is activated through gp130 by IL-27 and is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. Thus, IL-27 may be a cytokine, which activates both STAT1 and STAT3 through distinct receptor subunits, WSX-1 and gp130, respectively, to mediate its individual immune functions. 相似文献
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T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells 总被引:14,自引:0,他引:14
Chtanova T Tangye SG Newton R Frank N Hodge MR Rolph MS Mackay CR 《Journal of immunology (Baltimore, Md. : 1950)》2004,173(1):68-78