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Multiple genetic pathways have been shown to regulate life span and aging in the yeast Saccharomyces cerevisiae. Here we show that loss of a component of the RNA polymerase II complex, Hpr1p, results in a decreased life span. Although hpr1Delta mutants have an increased rate of recombination within the ribosomal DNA (rDNA) array, this is not accompanied by an increase in extrachromosomal rDNA circles (ERCs). Analyses of mutants that affect replication of the rDNA array and suppressors that reverse the phenotypes of the hpr1Delta mutant show that the reduced life span is associated with increased genomic instability but not with increased ERC formation. The hpr1Delta mutant acts in a pathway distinct from previously described mutants that reduce life span. 相似文献
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The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA 下载免费PDF全文
Schneiter R Guerra CE Lampl M Gogg G Kohlwein SD Klein HL 《Molecular and cellular biology》1999,19(5):3415-3422
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A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae 总被引:1,自引:0,他引:1 下载免费PDF全文
Chávez S Beilharz T Rondón AG Erdjument-Bromage H Tempst P Svejstrup JQ Lithgow T Aguilera A 《The EMBO journal》2000,19(21):5824-5834
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