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1.
J. P. Wang K. R. He X. M. Ding S. P. Bai Q. F. Zeng K. Y. Zhang 《Biological trace element research》2017,175(2):367-374
The primary objective of the current study was to assess the influence of early high-fat feeding on tissue trace element content in young male Wistar rats. Twenty weanling male Wistar rats were divided into two groups fed standard (STD) or high-fat diet (HFD) containing 10 and 31.6 % of total calories from fat, respectively, for 1 month. Serum lipid spectrum, apolipoproteins, glucose, insulin, adiponectin, and leptin levels were assessed. The level of trace elements was estimated using inductively coupled plasma mass spectrometry. High-fat feeding significantly increased epidydimal (EDAT) and retroperitoneal adipose tissue (RPAT), as well as total adipose tissue mass by 34, 103, and 59 %, respectively. Serum leptin levels in HFD animals were twofold higher than those in the control rats. No significant difference in serum lipid spectrum, apolipoproteins, glucose, adiponectin, and insulin was detected between the groups. HFD significantly altered tissue trace element content. In particular, HFD-fed animals were characterized by significantly lower levels of Cu, I, Mn, Se, and Zn in the liver; Cr, V, Co, Cu, Fe, and I content of EDAT; Co, Cu, I, Cr, V, Fe, and Zn concentration in RPAT samples. At the same time, only serum Cu was significantly depressed in HFD-fed animals as compared to the control ones. Hair Co, Mn, Si, and V levels were significantly increased in comparison to the control values, whereas Se and I content was decreased. HFD feeding induced excessive adiposity and altered tissue trace element content in rats without insulin resistance, adiponectin deficiency, and proatherogenic state. Hypothetically, trace element disbalance may precede obesity-associated metabolic disturbances. 相似文献
2.
BackgroundThe existing data demonstrate that both trace elements and amino acids play a significant role in neurodevelopment and brain functioning. Certain studies have demonstrated alteration of micronutrient status in children with cerebral palsy, although multiple inconsistencies exist.The objectiveof the present study was to assess serum trace element and mineral, as well as amino acid levels in children with cerebral palsy.Methods71 children with cerebral palsy (39 boys and 32 girls, 5.7 ± 2.3 y.o.) and 84 healthy children (51 boys and 33 girls, 5.4 ± 2.3 y.o.) were enrolled in the present study. Serum trace element and mineral levels were assessed using inductively-coupled plasma mass-spectrometry (ICP-MS). Amino acid profile was evaluated by means of high-pressure liquid chromatography (HPLC).ResultsChildren with cerebral palsy are characterized by significantly lower Cu and Zn levels by 6% and 8%, whereas serum I concentration exceeded the control values by 7%. A tendency to increased serum Mn and Se levels was also observed in patients with cerebral palsy. Serum citrulline, leucine, tyrosine, and valine levels were 15 %, 23 %, 15 %, and 11 % lower than those in healthy controls. Nearly twofold lower levels of serum proline were accompanied by a 44 % elevation of hydroxyproline concentrations when compared to the control values. In multiple regression model serum I, Zn, and hydroxyproline levels were found to be independently associated with the presence of cerebral palsy. Correlation analysis demonstrated a significant correlation between Cu, Mn, Se, I, and Zn levels with hydroxyproline and citrulline concentrations.ConclusionThe observed alterations in trace element and amino acid metabolism may contribute to neurological deterioration in cerebral palsy. However, the cross-sectional design of the study does not allow to estimate the causal trilateral relationships between cerebral palsy, altered trace element, and amino acid metabolism. 相似文献
3.
BackgroundEssential trace elements and minerals play a significant role in neurodevelopment. Although certain studies demonstrated impaired essential trace element and mineral status in children with ADHD, the existing data are insufficient. The objective of the present study was to assess serum trace element and mineral levels in children with ADHD.MethodsSerum trace element and mineral levels in 68 children with ADHD and 68 neurotypical controls were assessed using ICP-MS at NexION 300D (PerkinElmer Inc., USA) equipped with ESI SC-2 DX4 autosampler (Elemental Scientific Inc., USA).ResultsSerum Cr, Mg, and Zn levels in children with ADHD were 21 % (p = 0.010), 4 % (p = 0.005), and 7 % (p = 0. 001) lower as compared to the healthy controls, respectively. In turn, serum Cu/Zn values were 11 % higher than those in the control group. Age and gender had a significant impact on serum element levels in ADHD. Particularly, preschool children were characterized by significantly increased Cu (+8 %; p = 0.034), and Cu/Zn (+19 %; p < 0.001) values, whereas serum Zn (-9 %; p = 0.004) level was decreased. In primary school-aged children only 6 % (p = 0.007) lower Mg levels were observed. Both boys and girls with ADHD were characterized by 8 % (p = 0.016) lower serum Zn levels and 10 % (p = 0.049) higher Cu/Zn values when compared to neurotypical girls. Boys with ADHD also had significantly higher Cu/Zn, exceeding the respective control values by 12 % (p = 0.021), predominantly due to a 7 % (p = 0.035) decrease in serum Zn. Serum Mg levels were also found to be significantly lower than those in neurotypical children by 5 % (p = 0.007). In adjusted regression models serum Cr (β=-0.234; p = 0.009) and Cu/Zn (β = 0.245; p = 0.029) values were significantly associated with ADHD, respectively. Two-way ANOVA revealed a significant impact of ADHD on Cr, Mg, Zn, and Cu/Zn, whereas age was associated with Cu, I, Mg, Mo, and Cu/Zn, whereas gender accounted only for variability in serum Mn levels. Principal component analysis (PCA) also revealed significant contributions of Mg, Zn, and Cu/Zn values to ADHD variability.ConclusionsHypothetically, the observed decrease of essential trace elements, namely Mg and Zn, and elevation of Cu/Zn may significantly contribute to the risk of ADHD or its severity and/or comorbidity. 相似文献
4.
Ferahman M Unal E Sakoglu N Ersoy YE As A Ozdemir S 《Biological trace element research》2003,91(1):89-94
Metal ions are required as active components of several proteins, including pancreatic enzymes, and they can play important roles in the etiopathogenesis of acute pancreatitis. In the present study, we measured the concentrations of zinc (Zn) and copper (Cu) in both serum and pancreatic tissue, as markers of trace element status in an experimental acute pancreatitis model. Twenty-four male Wistar rats were divided into two groups: the experimental group (N=24) and the control group (N=10). Acute pancreatitis was induced by injection of 48% ethyl alcohol into the common biliary duct. The animals were sacrificed 24 h later to detect the concentrations of Zn and Cu. There was no significant difference in tissue Zn and Cu concentrations between control and experimental groups (p<0.05). However, in the acute pancreatitis group, serum Zn and Culevels were very significantly lower (p<0.001 and p<0.0001, respectively). In conclusuion, these findings suggested that altered mineral metabolism in serum and pancreatic tissue may have contributed to the pathophysiology of acute pancreatitis. 相似文献
5.
Kosar F Sahin I Acikgöz N Aksoy Y Kucukbay Z Cehreli S 《Biological trace element research》2005,107(1):1-10
It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients had significantly lower serum concentrations of Se and Zn than control subjects (p < 0.05 and p < 0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93 +/- 0.59 microg/L vs 1.06 +/- 0.29 microg/L; p < 0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70 +/- 0.92 vs 1.68 +/- 0.45; p < 0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity classes (p > 0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. 相似文献
6.
Acrylamide is an organic chemical which occurs in foods widespreadly consumed in diets worldwide. The purpose of this study was to evaluate the serum trace element levels (Fe, Cu, Zn, Mn, Cr, Se, Co, Ni, V, As, Mg, P, Li, K, Al) in Wistar rats exposed to acrylamide. Acrylamide was administered to the treatment groups at 2 and 5 mg/kg?body weight (bw)/day via drinking water for 90 days. Inductively coupled plasma mass spectrometry was used for the determination of serum trace element concentrations. Serum Zn, Se, Co, V and Mg concentrations of 5 mg/kg bw/day acrylamide-treated male rats were lower, whereas serum As concentration was higher than the same parameters of the controls rats. Similarly, serum Zn, Se, Co, V and Mg concentrations were decreased in 5 mg/kg?bw/day acrylamide-treated female rats compared with control rats. On the other hand, there were no significant differences between serum Fe, Cu, Mn, Cr, Ni, P, Li, K and Al concentrations of all groups. The results from this study provide evidence that dietary acrylamide intake adversely affects the serum trace elements status. 相似文献
7.
Sensitivity of the assay for Cu,Zn superoxide dismutase 3 (SOD3), the predominant form of SOD in serum, can be increased, and interferences caused by low-molecular-weight substances in the serum can be reduced by conducting the assay at pH 10 with xanthine/xanthine oxidase and acetylated cytochrome c (cyt c) as superoxide generator and detector, respectively. Serum SOD3 activity was assayed under these conditions in an experiment where weanling, male rats were fed diets for 6 weeks containing 3, 5 and 15 mg Zn/kg with dietary Cu set at 0.3, 1.5 and 5 mg Cu/kg at each level of dietary Zn. Serum SOD3 responded to changes in dietary Cu but not to changes in dietary Zn. A second experiment compared serum SOD3 activity to traditional indices of Cu status in weanling, male and female rats after they were fed diets containing, nominally, 0, 1, 1.5, 2, 2.5, 3 and 6 mg Cu/kg for 6 weeks. Serum SOD3 activity was significantly lower (P < .05) in male rats fed diets containing 0 and 1 mg Cu/kg and female rats fed diet containing 0 mg Cu/kg compared with rats fed diet containing 6 mg Cu/kg. These changes were similar to changes in liver Cu concentrations, liver cyt c oxidase (CCO) activity and plasma ceruloplasmin in males and females. Serum SOD3 activity was also strongly, positively correlated with liver Cu concentrations over the entire range of dietary Cu concentrations (R(2) = .942 in males, R(2) = .884 in females, P < .0001). Plots of serum SOD3 activity, liver Cu concentration, liver CCO activity and ceruloplasmin as functions of kidney Cu concentration all had two linear segments that intersected at similar kidney Cu concentrations (18-22 microg/g dry kidney in males, 15-17 microg/g dry kidney in females). These findings indicate that serum SOD3 activity is a sensitive index of Cu status. 相似文献
8.
Jean Nève Wojciech Wasowicz Dominique Quivy Nathalie Parij Andre Van Gossum Anne Peretz 《Biological trace element research》1995,47(1-3):147-153
Serum thiobarbituric acid reactive substances (TBARS), Zn, Cu, and Se concentrations were determined in 47 healthy adults
and in patients with diseases, such as renal in sufficiency, insulin-dependent diabetes mellitus, chronic pancreatitis, liver
cirrhosis, or cancer, in order to clarify the relationship between this indicator of lipid peroxidation and antioxidative
trace element status. TBARS levels were higher than control values in all pathological cases, except in cancer patients. Cu
levels in patients highly correlated with ferroxidase ceruloplasmin activity (r=0.86), but were only statistically different from controls in diabetics. Zn levels were lower than normal in dialysis, liver
cirrhosis, and cancer patients. Se levels were significantly decreased in all pathological cases. Half of the subjects with
liver cirrhosis or renal insufficiency and 3/4 of chronic pancreatitis or cancer patients had an active inflammatory process.
Despite intense modifications in determined indicators, no clear correlation could be demonstrated between the different parameters.
Basic antioxidative trace element status and inflammation are therefore not major determinants of TBARS levels in normal and
in pathological conditions, despite of the frequent association of low serum Zn and mainly low serum Se with high TBARS levels. 相似文献
9.
M. Fogle B. Daly M. Evans E. L. B. Justiniano C. J. Kovacs J. L. Shinpaugh L. H. Toburen 《Biological trace element research》2001,80(2):181-189
Although altered levels of circulating essential trace elements are known to accompany malignant disease, the lack of sensitivity
of conventional detection methods has generally limited their study to clinical conditions involving extensive disease (i.e.,
significant tumor burden). As such, the application of altered trace element levels as potential prognostic guides or as response
indicators subsequent to treatment has been of limited use. During this study, proton-induced X-ray emission spectroscopy
was evaluated as a tool to determine trace element imbalances in a murine tumor model. Using plasma from C57B1/6 mice bearing
the syngeneic Lewis lung carcinoma (LLCa), levels of Fe, Cu, and Zn, as well as changes in the Cu/Zn ratio, were measured
in animals carrying an increasing primary tumor burden. The plasma levels of Fe, Cu, and Zn were found to decrease significantly
7 d following implants of LLCa cells with no significant change observed in the Cu/Zn ratio. By d 21, however, an increase
in the Cu/Zn ratio was found to accompany increased growth of the LLCa tumor; the plasma levels of Cu had returned to normal
levels, whereas both the Fe and Zn plasma levels remained lowered. Collectively, the results suggest that although a net change
in individual plasma trace element concentrations might not be accurately associated with tumor growth, a clear relationship
was established between the Cu/Zn ratio and tumor size. 相似文献
10.
Feridun Kosar Ibrahim Sahin Nusret Acikgöz Yuksek Aksoy Zehra Kucukbay Sengul Cehreli 《Biological trace element research》2005,107(1):1-9
It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes
in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of
selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients
had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59
μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity
classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We
suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high
Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. 相似文献
11.
Trace elements are known to have a key role in myocardial metabolism. The accumulation (cobalt, arsenic, copper) or deficiency
(selenium, zinc) of trace elements may be responsible for idiopathic dilated cardiomyopathy. We investigated the trace element
concentrations (Cu, Zn, Mg) in sera from patients with dilated cardiomyopathy by atomic absorption spectrophotometry. We observed
that patients with dilated cardiomyopathies have higher copper and lower zinc concentrations in serum than healthy controls.
The magnesium concentrations of patients did not differ significantly from that of control subjects. 相似文献
12.
Michael Krachler Erich Rossipal Dusanka Micetic-Turk 《Biological trace element research》1999,68(2):121-135
Concentrations of trace elements in newborns, infants, and adults may be significantly different from each other. Serum trace element reference ranges for different age groups are of value for diagnostic purposes. Inductively coupled plasma-mass spectrometry was applied to the determination of the 21 trace elements Ba, Be, Bi, Ca, Cd, Co, Cs, Cu, La, Li, Hg, Mg, Mn, Mo, Pb, Rb, Sb, Sn, Sr, TI, and Zn in a total of 117 sera of individuals representing different age groups. After microwave-assisted acid digestion with high-purity reagents, 20 umbilical cord sera, 5 sera of fully breast-fed infants, 6 sera of formula-fed infants, 66 sera of patients suffering internal diseases, and 20 sera of healthy blood donors were analyzed for trace elements. One serum and two whole-blood reference materials were analyzed for quality control. Experimental concentrations were in good agreement with certified values. Umbilical cord serum concentrations of the essential elements Ca, Co, Cu, and Mg and of the nonessential and toxic elements Ba, Be, Li, Pb, and Sb were elevated compared to the elemental concentrations in the sera of infants and adults. Serum levels of Ba, Ca, Co, Mn, Pb, and Sb of infants were much higher and serum Cu was significantly lower than in adults. Serum Cu increased significantly with age (newborns: 353 microg/L; infants: 755 microg/L; healthy adults: 810 microg/L), whereas for other trace elements no age-dependence could be established. 相似文献
13.
Atilla Cayir Hakan Doneray Nezahat Kurt Zerrin Orbak Avni Kaya Mehmet Ibrahim Turan Abdulkadir Yildirim 《Biological trace element research》2014,157(2):95-100
Obesity is a multifactorial disease developing following impairment of the energy balance. The endocrine system is known to be affected by the condition. Serum thyroid hormones and trace element levels have been shown to be affected in obese children. Changes in serum thyroid hormones may result from alterations occurring in serum trace element levels. The aim of this study was to evaluate whether or not changes in serum thyroid hormone levels in children with exogenous obesity are associated with changes in trace element levels. Eighty-five children diagnosed with exogenous obesity constituted the study group, and 24 age- and sex-matched healthy children made up the control group. Serum thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), thyroglobulin (TG), selenium (Se), zinc (Zn), copper (Cu), and manganese (Mn) levels in the study group were measured before and at the third and sixth months of treatment, and once only in the control group. Pretreatment fT4 levels in the study group rose significantly by the sixth month (p?=?0.006). Zn levels in the patient group were significantly low compared to the control group (p?=?0.009). Mn and Se levels in the obese children before and at the third and sixth months of treatment were significantly higher than those of the control group (p?=?0.001, p?=?0.001). In conclusion, fT4, Zn, Cu, Mn, and Se levels are significantly affected in children diagnosed with exogenous obesity. The change in serum fT4 levels is not associated with changes in trace element concentrations. 相似文献
14.
Postpartum scalp hair samples from 82 term-pregnancy mother/neonate pairs were analyzed for their concentration of zinc (Zn),
copper (Cu), cadmium (Cd), and lead (Pb), using inductively coupled plasma-mass spectrometry. Maternal and neonatal Zn concentrations
had geometric means (and 99% confidence intervals) of 122.5 μg/g (117.9–131.5 μg/g) and 146.9 μg (141.5–156.7 μg/g) respectively.
Corresponding Cu values were 18.4 μg/g (17.6–23.8 μg/g) and 6.7 μg/g (6.3–7.6 μg/g). Those of Cd were 0.49 μg/g (0.47–0.69
μg/g) in the mothers and 0.57 μg/g (0.55–0.86 μg/g) in the neonates. For Pb, they were 7.95 μg/g (7.60–9.32 μg/g) and 4.56
μg/g (4.39–5.56 μg/g). Cigaret smoking, despite its relatively low prevalence (19.5%), was associated with lower Zn and higher
Cd and Pb concentrations and in lower Zn/Cd and Zn/Pb molar concentration ratios. Smoking also altered interelemental relationships,
particularly those of Zn with Cd and Pb and those between Cd and Pb. Smoking frequency appeared to show negative dose-response
effects on maternal and neonatal Zn concentrations, Zn/Pb molar concentration ratios, and birth weight. Mothers with a history
of oral contraceptive (OC) usage had significantly higher Cu concentrations and lower Zn/Cu molar concentration ratios than
nonusers, with the highest Cu concentrations and lowest Zn/Cu values being associated with third-generation OCs. No similar
effects were elicited in the respective neonatal Cu concentrations. Neither alcohol consumption nor prenatal supplementation
with iron and/or folic acid had discernible effects on the maternal or neonatal elemental concentrations. The data from this
study suggest that in a given population of term-pregnancy mothers and neonates, significant interindividual variations in
hair trace element concentrations can occur, irrespective of commonality of general environment, and that lifestyle factors,
including cigaret smoking and OC usage history, can be significant contributory factors to such variations. The data are discussed
in relation to the effects of smoking-associated exposure to Cd and Pb exposure on Zn availability for placental transfer,
as well as on the quantitative maternal Zn supply levels to the fetus resulting from the known tendency of smokers to have
lower dietary intakes of Zn. The higher Cu concentrations in OC users are discussed in relation to altered Cu metabolism,
characterized by increased synthesis of the Cu-binding protein, ceruloplasmin, as an acute-phase antioxidant response to altered
lipid profile and increased lipid oxidation. 相似文献
15.
Reye’s syndrome (Rs) is an acute illness in children manifested by encephalopathy and fatty degeneration of the liver. The
syndrome may be secondary to injury of mitochondria following a toxic insult in a susceptible individual with a viral illness.
Since the response to infection often involves a change in trace metals, we investigated the metal status of patients with
Rs. Decreased levels of serum and liver selenium (Se) and copper (Cu) were demonstrated via PIXE analysis, in addition to
an increase in serum iron (Fe) and zinc (Zn). In a subsequent study using a rat animal model of Rs, the hepatotoxin 4-pentenoic
acid (4-PA) produced similar changes in serum and liver trace metals. Serum and liver Se levels were also significantly depleted
in rats exposed to another toxin, valproic acid (VPA). Aspirin, known to complex metals, may also be associated with Rs. Rats
chronically exposed to aspirin had decreased serum Se, Fe, and Zn compared to controls. Selenium was also decreased in liver,
as was Cu. Atomic absorption spectrophotometric analysis of serum and liver Cu for mice exposed to aspirin and influenza A
virus were also studied. In liver, Cu was significantly decreased in mice on Cu-deficient diets but, not in control mice exposed
to virus, or aspirin and virus. For the Se-deficient animals, liver Cu was not different from controls, but there was an increase
in tissue Cu for Se-sufficient mice exposed to virus and aspirin; Cu levels were decreased in sera of this latter group. Serum
Cu was increased in Cu-sufficient mice exposed to virus and aspirin. The above data are of biologic and toxicologic interest
because of metalloenzyme localization in the mitochondrial matrix, the cellular compartment showing the greatest degree of
pathologic change in Rs. In particular, Se-dependent gluthathione peroxidase is a major deterent of peroxidative damage of
lipid membranes. The accumulated evidence suggests that alteration of trace metals, e.g., decrease in Se, may promote peroxidation
of mitochondrial membranes in patients with Rs. 相似文献
16.
Cigarette smoking has been established as a major risk factor for atherosclerosis and also for lung cancer. Nicotine is one of the major components of cigarette smoke which is believed to be partly responsible for the deleterious effect of cigarette smoke. There was significant alteration in the concentration of glycosaminoglycans (GAG) in rats exposed to cigarette smoke. Administration of nicotine to rats has been found to decrease many of GAG fractions in the aorta, liver and heart and increase in the lungs. The increase in GAG now observed in lung tissue in rats administered nicotine and those exposed to cigarette smoke may be involved in the increased incidence of lung cancer in smokers. Increased activity of many of GAG hydrolysing enzymes indicates increased degradation of GAG. Sulphate metabolism in the liver is also significantly altered by nicotine. Thus administration of nicotine to rats caused alteration in the metabolism of GAG which are similar to those observed on exposure of rats to cigarette smoke, indicating that nicotine content of the tobacco smoke may partly be responsible for the effect on GAG observed on exposure to cigarette smoke. 相似文献
17.
The effects of a zinc-deficient (ZD) diet on the growth and trace element concentrations of various organs (body hair, liver,
kidney, gastrocnemius muscle, and femur) of male rats were studied. Furthermore, these trace element concentrations of the
above-mentioned organs in male rats neonatally treated with l-monosodium glutamate (MSG) are compared with those of the ZD rats.
The ZD rats showed growth retardation compared to rats fed a zincadequate diet (controls). The feed efficiency of the ZD rats
was only one-fifth of the controls. This is one reason why the ZD rats showed retarded growth. Body hair concentration of
zinc (Zn) in the ZD rats was significantly lower than in the controls. On the other hand, copper (Cu), manganese (Mn), and
iron (Fe) concentrations in the body hair were significantly higher in the ZD rats than in the controls. Moreover, the apparent
absorption rate of these trace elements was significantly higher in the ZD rats than in the controls. The reason for the decrease
in Zn contents of the body hair in the ZD rats is probably the reduced dietary Zn intake. Liver and kidney concentrations
of Zn in the ZD rats were significantly lower than in the controls. Femur Zn concentrations in the control rats showed higher
values than in the ZD rats. Cu and Mn concentrations in the femur in the ZD rats showed higher values than in the controls.
Ninh et al. suggested that growth retardation in ZD rats is the result of a decrease in protein biosynthesis. The results
of this study support their theory.
The reasons for the use of MSG-treated rats in this study are as follows. (1) We reported on the head hair concentration of
the above-mentioned elements from pituitary dwarfism (human growth hormone deficient) patients. In that study, the sample
was restricted to head hair from pituitary dwarfism patients. More detailed physiological data may be obtained by the used
of MSG-treated rats. (2) We took notice of many resemblances between the pituitary dwarfism patients and the MSG-treated rats
in morbidity.
The MSG-treated rats showed a severe growth retardation compared to NaCl-treated controls. Zn concentration in the body hair
was significantly higher in the MSG-treated rats than in the NaCl-treated controls. For the other trace element concentrations,
there were no significant differences between the MSG-treated rats and the NaCl-treated controls. The concentrations of these
trace elements in the liver of the MSG-treated rats were lower than in the NaCl-treated controls. In the MSG-treated rats,
the concentrations of Zn and Cu in the femur were higher than in the NaCl-treated controls. However, the Fe concentration
in the femur of the MSG-treated rats showed lower values compared with NaCl-treated controls.
The results of this study suggest that the reduction of rat growth hormone (rGH) secretion and/or its synthesis are a consequence
of the impairment of rGH anabolic effects. Furthermore it indicates that MSG-treated rats are useful as an in vivo model for
the study of the effects of GH. 相似文献
18.
Domej W Krachler M Goessler W Maier A Irgolic KJ Lang JK 《Biological trace element research》2000,78(1-3):53-66
In this study, a number of selected trace elements and clinically relevant parameters were compared between thoracic empyemata
and the corresponding sera for a better understanding of the trace element distribution between these two compartments. Serum-empyema
pairs were obtained from 13 patients and quantified for selected and essential trace elements, namely copper (Cu), zinc (Zn),
manganese (Mn), rubidium (Rb), and magnesium (Mg), by inductively coupled plasma-mass spectrometry (ICP-MS). In addition,
the concentrations of the following clinical laboratory parameters were analyzed by standard methods: total protein, leukocyte
count, lactate dehydrogenase, glucose, pH, and the C-reactive protein.
Individual concentrations of the elements determined in the empyemata were frequently higher than in pleural effusions of
any other benign or malignant condition except for Cu. Serum Cu exceeded the normal range (600–1400 μg/kg) in 6 out of 13
patients (median 1410 μg/kg). In the empyemata, Zn concentrations (median 2000 μg/kg) were characteristically higher than
in the sera (median 450 μg/kg) and exceeded the upper limit for serum (1200 μg/kg) in 8 of the 13 patients. Manganese concentrations
in the empyemata (median 2.7 μg/kg) were also higher compared to corresponding sera, although they stayed within the limits
considered normal for serum of healthy adults (upper limit 2.9 μg/kg). Rubidium was also moderately higher in most empyemata
(median 290 μg/kg) and exceeded the upper limit for serum (560 μg/kg) in two patients. The median concentration of the essential
element magnesium was higher in the empyemata (23 mg/kg) than in the sera (21 mg/kg). However, all serum Mg concentrations
except three remained within the normal range (17–22 mg/kg).
Removal of large amounts of empyematous fluid may deprive the body of trace elements and can cause suboptimal or deficient
trace element status and homeostasis. Recuperation will be accelerated by compensatory supplementation of trace elements.
Therefore, selective medication with adequate trace element compounds in patients with thoracic empyema can be generally recommended
for zinc. The other elements need not necessarily be monitored or substituted, because of their stable concentrations in the
serum. Rb may have a biological impact, but deficiency symptoms in man are not clearly defined.
Deceased. 相似文献
19.
Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children 总被引:2,自引:0,他引:2
Armutcu F Ozerol E Gurel A Kanter M Vural H Yakinci C Akyol O 《Biological trace element research》2004,102(1-3):1-10
Antiepileptic drugs could cause changes in the trace element status of the body. Valproic acid (VPA) is a very effective anticonvulsant
agent widely used in the management of various forms of epilepsy. Nail trace element content is a reliable index of trace
element nutritional status of the body. To determine whether some of the side effects of antiepileptic drugs could be the
result of zinc (Zn) depletion within tissues, Zn concentrations as well as copper (Cu) concentrations in nail and serum in
59 children having various types of epilepsy receiving valproate and 31 controls were assessed. Although serum Zn level in
epileptic patients was found to be decreased, there was no difference in nail samples when compared to controls. There was
a statistically significant increase in nail Cu level in epileptic patients when compared to controls. On the other hand,
serum Cu levels were not different between the groups. Although none of our patients showed any symptoms of Cu elevation and
Zn depletion, we should pay attention to potential body trace element changes in patients with epilepsy under VPA treatment.
In conclusion, our results indicate that serum trace metal homeostasis might be affected by VPA therapy, but not by the convulsive
disorder itself. 相似文献
20.
Ying Li Zhen-Long Kang Na Qiao Lian-Mei Hu Yong-Jiang Ma Xiao-Huan Liang Ji-Long Liu Zeng-Ming Yang 《Biological trace element research》2017,175(1):10-16
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, which mainly involves the joints. RA is prevalent worldwide with increasing prevalence in elderly people. The mechanism of RA pathogenesis is still undefined, and it is interplaying between genetic susceptibility and environmental factors. Although risk factors for RA are not fully established, various studies have focused on the role of trace elements in association with RA. Trace elements act as co-factors for most of the enzymes, and their deficiency is associated with many untoward effects on human health. The homeostatic alterations in the metabolism of trace elements may partly be due to inflammatory response in RA. The objective of the present study was to determine the serum concentrations and correlation of zinc, copper, and iron in RA patients and healthy controls. The study comprised of 61 RA patients and 61 age- and sex-related healthy individuals of Pakistani population. Serum levels of Zn, Cu, and Fe were measured in all the participants by atomic absorption spectrophotometer. Serum Zn and Fe were significantly reduced in the RA patients than those in the healthy controls. Serum Cu concentrations were found elevated in the RA patients. Correlation studies of trace elements determine that there was negative correlation between Zn and Cu in the RA patients and no correlation in the control group. It is very important to explore the deficiency of essential trace metals in biological samples of the RA patients in different populations which may be helpful for diagnosis and supplementary management of rheumatoid arthritis patients. 相似文献