首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 0 毫秒
1.
Recent advances in the study of the genetics and genomics of urochordates testify to a renewed interest in this chordate subphylum, believed to be the most primitive extant chordate relatives of the vertebrates. In addition to their primitive nature, many features of their reproduction and early development make the urochordates ideal model chordates for developmental genetics. Many urochordates spawn large numbers of transparent and externally developing embryos on a daily basis. Additionally, the embryos have a defined and well-characterized cell lineage until the end of gastrulation. Furthermore, the genomes of the urochordates have been estimated to be only 5-10% of the size of the vertebrates and to have fewer genes and less genetic redundancy than vertebrates. Genetic screens, which are powerful tools for investigating developmental mechanisms, have recently become feasible due to new culturing techniques in ascidians. Because hermaphrodite ascidians are able to self-fertilize, recessive mutations can be detected in a single generation. Several recent studies have demonstrated the feasibility of applying modern genetic techniques to the study of ascidian biology.  相似文献   

2.
Statistical methods in genetics   总被引:1,自引:0,他引:1  
In recent years, a very large variety of statistical methodologies, at various levels of complexity, have been put forward to analyse genotype data and detect genetic variations that may be responsible for increasing the susceptibility to disease. This review provides a concise account of a number of selected statistical methods for population-based association mapping, from single-marker tests of association to multi-marker data mining techniques for gene-gene interaction detection.  相似文献   

3.
4.
5.
Scientific trends are analyzed in the field of medical genetics in the Ukraine for a twenty-year period. Prospects of further development are outlined for six main problems concerning development and ageing, genetics of endocrine disturbances, immune genetics, oncogenetics, effect of mutagenic and teratogenic factors on man and elaboration of preventive measures against various harmful effects.  相似文献   

6.
The joint analysis of spatial and genetic data is rapidly becoming the norm in population genetics. More and more studies explicitly describe and quantify the spatial organization of genetic variation and try to relate it to underlying ecological processes. As it has become increasingly difficult to keep abreast with the latest methodological developments, we review the statistical toolbox available to analyse population genetic data in a spatially explicit framework. We mostly focus on statistical concepts but also discuss practical aspects of the analytical methods, highlighting not only the potential of various approaches but also methodological pitfalls.  相似文献   

7.
8.
A series of 60 chimpanzees (Pan troglodytes) were tested for their human-type A-B-O blood groups and for ten simian-type blood factors. Of the 60 chimpanzees four were group O and 56 group A; combining this with our previous results, among 274 chimpanzees there were 36 group O and 238 group A. Gene frequency analysis of the V-A-B types (determined by three antisera, anti- V c, anti- A c and anti- B c) of the 60 chimpanzees indicated inheritance by four allelic genes, namely, the amorphic gene v and the three additional alleles vA, vB and V. This theory allows for the existence of ten genotypes but only seven V-A-B phenotypes, since the type V.AB is excluded. Gene frequency analysis confirmed that Cc and cc are contrasting antigens determined by corresponding allelic genes. The distribution of the C-c-E-F types among the 60 chimpanzees, as well as among 133 chimpanzees previously tested, is compatible with the postulation of five allelic genes, namely, the amorph c, and the alleles CE, CF, CEF and the very rare allele C. The blood factor G c appears to define a separate blood group system, independent of the V-A-B and C-E-F systems. The newly defined blood factor Lindsay appears to be related to the V-A-B system, while factor H c may be related to the C-E-F system.  相似文献   

9.
10.
11.
12.
13.
14.
浅谈案例教学法在遗传学教学中的应用   总被引:1,自引:2,他引:1  
吴娟 《生物学杂志》2010,27(3):109-110
"案例教学法"通过有目的、有计划、有针对性地引导学生学习和运用理论知识对具体案例进行观察分析,在互动借鉴中分析问题,实现理论知识与典型事物的有机结合,使学生置身于用理论解决实际问题的的过程中,从而提高其观察能力和思维能力,有利于提高遗传学课程教学的实效性。  相似文献   

15.
16.
A course in medical genetics for first-year medical students was developed with the use of alternative methods of instruction, including audiovisual materials and computer-assisted instruction. The use of this methodology enabled students to consider many significant areas of medical genetics, without a dependency on the traditional lecture-based instructional format. Seventy-eight percent of the students identified the alternative instructional methods as an enhancement to their education. These students performed a mean of 6% better on class examinations.  相似文献   

17.
18.
19.
20.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号