共查询到20条相似文献,搜索用时 31 毫秒
1.
Felix Eckstein Wolfgang Wirth Martin I Hudelmaier Susanne Maschek Wolfgang Hitzl Bradley T Wyman Michael Nevitt Marie-Pierre Hellio Le Graverand David Hunter 《Arthritis research & therapy》2009,11(3):R90-10
Introduction
The aim was to investigate the relationship of cartilage loss (change in medial femorotibial cartilage thickness measured with magnetic resonance imaging (MRI)) with compartment-specific baseline radiographic findings and MRI cartilage morphometry features, and to identify which baseline features can be used for stratification of fast progressors. 相似文献2.
Miriam Bellido Laura Lugo Jorge A Roman-Blas Santos Castañeda Jose R Caeiro Sonia Dapia Emilio Calvo Raquel Largo Gabriel Herrero-Beaumont 《Arthritis research & therapy》2010,12(4):R152-11
Introduction
Osteoporosis (OP) increases cartilage damage in a combined rabbit model of OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at subchondral bone aggravates cartilage damage in this experimental model. 相似文献3.
Shawn P Grogan Shigeru Miyaki Hiroshi Asahara Darryl D D'Lima Martin K Lotz 《Arthritis research & therapy》2009,11(3):R85
Introduction
Recent findings suggest that articular cartilage contains mesenchymal progenitor cells. The aim of this study was to examine the distribution of stem cell markers (Notch-1, Stro-1 and VCAM-1) and of molecules that modulate progenitor differentiation (Notch-1 and Sox9) in normal adult human articular cartilage and in osteoarthritis (OA) cartilage. 相似文献4.
Kuroki H Nakagawa Y Mori K Kobayashi M Yasura K Okamoto Y Suzuki T Nishitani K Nakamura T 《Arthritis research & therapy》2008,10(4):R78
Introduction
There is a lack of data relating the macroscopic appearance of cartilage to its ultrasound properties. The purpose of the present study was to evaluate degenerated cartilage and healthy-looking cartilage using an ultrasound system. 相似文献5.
Koga H Shimaya M Muneta T Nimura A Morito T Hayashi M Suzuki S Ju YJ Mochizuki T Sekiya I 《Arthritis research & therapy》2008,10(4):R84
Introduction
Current cell therapy for cartilage regeneration requires invasive procedures, periosteal coverage and scaffold use. We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect. 相似文献6.
Hui Geng Stefan Carlsen Kutty Selva Nandakumar Rikard Holmdahl Anders Aspberg Åke Oldberg Ragnar Mattsson 《Arthritis research & therapy》2008,10(6):R134
Introduction
Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice. 相似文献7.
David Pretzel Dirk Pohlers Sönke Weinert Raimund W Kinne 《Arthritis research & therapy》2009,11(1):R25-20
Introduction
Activated synovial fibroblasts are thought to play a major role in the destruction of cartilage in chronic, inflammatory rheumatoid arthritis (RA). However, profound insight into the pathogenic mechanisms and the impact of synovial fibroblasts in the initial early stages of cartilage destruction is limited. Hence, the present study sought to establish a standardised in vitro model for early cartilage destruction with native, intact cartilage in order to analyse the matrix-degrading capacity of synovial fibroblasts and their influence on cartilage metabolism. 相似文献8.
Kristin Andreas Thomas Häupl Carsten Lübke Jochen Ringe Lars Morawietz Anja Wachtel Michael Sittinger Christian Kaps 《Arthritis research & therapy》2009,11(1):R15-14
Introduction
Rheumatoid arthritis (RA) leads to progressive destruction of articular cartilage. This study aimed to disclose major mechanisms of antirheumatic drug action on human chondrocytes and to reveal marker and pharmacological target genes that are involved in cartilage dysfunction and regeneration. 相似文献9.
Jonathan B Catterall Daniel Barr Michael Bolognesi Robert D Zura Virginia B Kraus 《Arthritis research & therapy》2009,11(2):R55
Introduction
Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically modified amino acids in the form of isomerized aspartate and that its liberation due to osteoarthritis (OA)-related cartilage degradation could reflect OA severity. 相似文献10.
Andreas K Lübke C Häupl T Dehne T Morawietz L Ringe J Kaps C Sittinger M 《Arthritis research & therapy》2008,10(1):R9
Background
Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic autoimmune disease that leads to progressive cartilage destruction. Advances in the treatment of RA-related destruction of cartilage require profound insights into the molecular mechanisms involved in cartilage degradation. Until now, comprehensive data about the molecular RA-related dysfunction of chondrocytes have been limited. Hence, the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction of cartilage that are expressed by human chondrocytes. 相似文献11.
Otsuki S Taniguchi N Grogan SP D'Lima D Kinoshita M Lotz M 《Arthritis research & therapy》2008,10(3):R61
Introduction
Changes in sulfation of cartilage glycosaminoglycans as mediated by sulfatases can regulate growth factor signaling. The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes. 相似文献12.
Miyamoto T Muneta T Tabuchi T Matsumoto K Saito H Tsuji K Sekiya I 《Arthritis research & therapy》2010,12(6):R206
Introduction
Synovial mesenchymal stem cells (MSCs) have high proliferative and chondrogenic potentials, and MSCs transplanted into the articular cartilage defect produce abundant extracellular matrix. Because of similarities between the articular cartilage and the intervertebral disc cartilage, synovial MSCs are a potential cell source for disc regeneration. Here, we examined the effect of intradiscal transplantation of synovial MSCs after aspiration of nucleus pulposus in rabbits. 相似文献13.
Karsdal MA Madsen SH Christiansen C Henriksen K Fosang AJ Sondergaard BC 《Arthritis research & therapy》2008,10(3):R63
Introduction
Physiological and pathophysiological cartilage turnover may coexist in articular cartilage. The distinct enzymatic processes leading to irreversible cartilage damage, compared with those needed for continuous self-repair and regeneration, remain to be identified. We investigated the capacity of repair of chondrocytes by analyzing their ability to initiate an anabolic response subsequent to three different levels of catabolic stimulation. 相似文献14.
15.
Pineda C Amezcua-Guerra LM Solano C Rodriguez-Henríquez P Hernández-Díaz C Vargas A Hofmann F Gutiérrez M 《Arthritis research & therapy》2011,13(1):R4
Introduction
In this study, we aimed to investigate ultrasonographic (US) changes suggestive of gouty arthritis in the hyaline cartilage, joints and tendons from asymptomatic individuals with hyperuricemia. 相似文献16.
Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats
Introduction
The effect of intra-articular injection of matrix metalloproteinase (MMP)-3 inhibitor was investigated in a rat model to understand the role of MMP-3 in cartilage degradation induced by excessive loading from running. 相似文献17.
García S Forteza J López-Otin C Gómez-Reino JJ González A Conde C 《Arthritis research & therapy》2010,12(6):R224
Introduction
Rheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases (MMPs) implicated in homeostasis of the extracellular matrix play a central role in cartilage degradation. However, the role of specific MMPs in arthritis pathogenesis is largely unknown. The aim of the present study was to investigate the role of Mmp-8 (collagenase-2) in an arthritis model. 相似文献18.
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
Ian D Welch Matthew F Cowan Frank Beier Tully M Underhill 《Arthritis research & therapy》2009,11(1):R14
Introduction
Osteoarthritis (OA) is a debilitating disease with poorly defined aetiology. Multiple signals are involved in directing the formation of cartilage during development and the vitamin A derivatives, the retinoids, figure prominently in embryonic cartilage formation. In the present study, we examined the expression of a retinoid-regulated gene in murine models of OA. 相似文献19.
Simulating the swelling and deformation behaviour in soft tissues using a convective thermal analogy
Background
It is generally accepted that cartilage adaptation and degeneration are mechanically mediated. Investigating the swelling behaviour of cartilage is important because the stress and strain state of cartilage is associated with the swelling and deformation behaviour. It is well accepted that the swelling of soft tissues is associated with mechanical, chemical, and electrical events. 相似文献20.
Nelson AE Shi XA Schwartz TA Chen JC Renner JB Caldwell KL Helmick CG Jordan JM 《Arthritis research & therapy》2011,13(2):R37