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Grégoire Stik Ginette Dambrine Sébastien Pfeffer Denis Rasschaert 《Journal of virology》2013,87(1):80-93
Gallid herpesvirus 2 (GaHV-2) is an oncogenic herpesvirus that causes T lymphoma in chicken. GaHV-2 encodes a basic leucine zipper (bZIP) protein of the AP-1 family, Meq. Upon formation of homo- or heterodimers with c-Jun, Meq may modulate the expression of viral and cellular genes involved in lymphomagenesis. GaHV-2 also encodes viral microRNAs (miRNAs) involved in latency and apoptosis escape. However, little is known about cellular miRNA deregulation during the development of GaHV-2-associated lymphoma. We determined the cellular miRNA expression profiles of chickens infected with a very virulent strain (RB-1B) or a vaccine strain (CVI988) or noninfected. Among the most deregulated cellular miRNAs, we focused our efforts on gga-miR-21, which is upregulated during GaHV-2 infection. We mapped the gga-miR-21 promoter to the 10th intron of the TMEM49 gene and found it to be driven by AP-1- and Ets-responsive elements. We show here that the viral oncoprotein Meq binds to this promoter, thereby transactivating gga-miR-21 expression. We confirmed that this miRNA targets chicken programmed death cell 4 (PDCD4) and promotes tumor cell growth and apoptosis escape. Finally, gga-miR-21 was overexpressed only during infection with a very virulent strain (RB-1B) and not during infection with a nononcogenic strain (CVI988), providing further evidence for its role in GaHV-2 lymphomagenesis. Our data therefore suggest an additional role for Meq in GaHV-2-mediated lymphomagenesis through the induction of miR-21 expression. 相似文献
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《Cell cycle (Georgetown, Tex.)》2013,12(20):4200-4212
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An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription 总被引:1,自引:0,他引:1
Knouf EC Garg K Arroyo JD Correa Y Sarkar D Parkin RK Wurz K O'Briant KC Godwin AK Urban ND Ruzzo WL Gentleman R Drescher CW Swisher EM Tewari M 《Nucleic acids research》2012,40(2):499-510
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Transcriptional regulatory elements of the RAS2 gene of Saccharomyces cerevisiae 总被引:2,自引:1,他引:1
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J Lisziewicz J Brown D Breviario T Sreenath N Ahmed R Koller R Dhar 《Nucleic acids research》1990,18(14):4167-4174
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RNA polymerase III transcribes human microRNAs 总被引:1,自引:0,他引:1