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1.
The reference ranges of the trace elements Al, As, Be, B, Cd, Co, Cu, Fe, Mn, Mo, Ni, Pb, Li, Rb, Se, Sr, and Zn were determined
by inductively coupled plasma-mass spectrometry (ICP-MS) in sera of a group of free-ranging plains viscachas of the pampa
grasslands of Argentina. The values were compared with those of a small group of captive plains viscachas of the Zurich Zoo
with diabetes and bilateral cataracts. In addition, a method for digestion of whole-blood samples is described for the trace
element determination. Significant differences in the concentration of trace elements in the two groups of animals are discussed.
No correlation was found between the levels of selenium and of other trace elements compared to the formation of cataracts. 相似文献
2.
Gellein K Garruto RM Syversen T Sjøbakk TE Flaten TP 《Biological trace element research》2003,96(1-3):39-60
Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) are neurodegenerative disorders that occurred
with extremely high frequency among the native population on Guam, especially in the 1950s and 1960s, but have substantially
declined over the last half-century. The etiology of these diseases is unknown, but the most plausible hypothesis centers
on imbalances in essential and toxic metals. We have determined the concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in
formalin-fixed brain tissue collected during the period 1979–1983 from eight Guamanian patients with ALS, four with PDC, and
five control subjects using high-resolution inductively coupled plasma-mass spectrometry. The concentrations of Cd are markedly
and significantly elevated both in gray and white matter in ALS, but not in PDC patients. The concentrations of Zn are elevated
for both patient groups, in both gray and white matter, but only the difference in gray matter for PDC is significant. For
the other metals, no significant differences are found. 相似文献