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Transactivation by the adenovirus E1A gene 总被引:3,自引:0,他引:3
J R Nevins P Raychaudhuri A S Yee R J Rooney I Kovesdi R Reichel 《Biochimie et biologie cellulaire》1988,66(6):578-583
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Identification of a nuclear factor that binds to a conserved sequence of the I-A beta gene 总被引:8,自引:0,他引:8
A Celada M Shiga M Imagawa J Kop R A Maki 《Journal of immunology (Baltimore, Md. : 1950)》1988,140(11):3995-4002
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Partial purification of a nuclear protein that binds to the CCAAT box of the mouse alpha 1-globin gene. 总被引:32,自引:16,他引:16
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We enriched a fraction from nuclear extracts of murine erythroleukemia cells which contains a protein able to form stable complexes with the promoter region of the alpha 1-globin gene. Binding activity, which is present in mouse brain and a variety of cultured mouse and human cell lines, is not erythroid cell specific. Binding studies with alpha-globin gene promoter deletion mutants as well as DNase I footprinting and dimethyl sulfate protection studies showed that the factor bound specifically to the CCAAT box of the alpha 1 promoter. Enriched factor preparations exhibited weak binding to the promoter region of the beta maj-globin gene. This suggests that this protein could bind differentially to these two promoters in vivo. The enriched factor may be a ubiquitous nuclear protein involved in the differential regulation of the alpha 1- and beta maj-globin genes. 相似文献
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