共查询到20条相似文献,搜索用时 15 毫秒
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Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template
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Lu H Pise-Masison CA Fletcher TM Schiltz RL Nagaich AK Radonovich M Hager G Cole PA Brady JN 《Molecular and cellular biology》2002,22(13):4450-4462
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Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
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Guidez F Howell L Isalan M Cebrat M Alani RM Ivins S Hormaeche I McConnell MJ Pierce S Cole PA Licht J Zelent A 《Molecular and cellular biology》2005,25(13):5552-5566
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Suhara W Yoneyama M Kitabayashi I Fujita T 《The Journal of biological chemistry》2002,277(25):22304-22313
Infections of bacteria and viruses induce host defense reactions known as innate responses including the activation of interferon regulatory factor-3 (IRF-3), critical for the activation of type I interferon system. Upon immediate early signals triggered by the infection, IRF-3 is phosphorylated and a homodimer results. The homodimer complexes with the coactivator CREB-binding protein (CBP)/p300 in the nucleus; thus, holocomplex of IRF-3 competent in DNA binding is generated. We showed CBP/p300 to be indispensable for the DNA binding activity of the holocomplex and to aid the binding through direct interaction with the DNA. We demonstrated that p300 binds with the IRF-3 homodimer via a Q-rich domain and that an intact histone acetyltransferase (HAT) domain is indispensable for the DNA binding of the holocomplex along with a CH3 domain, which connects the HAT and Q-rich domains. These results highlight a novel function of CBP/p300: direct involvement in sequence-specific DNA binding. Furthermore, the critical function of these domains in virus-induced gene activation was demonstrated in vivo by using p300 mutants. 相似文献
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Balasubramanyam K Varier RA Altaf M Swaminathan V Siddappa NB Ranga U Kundu TK 《The Journal of biological chemistry》2004,279(49):51163-51171
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Chakraborty S Senyuk V Sitailo S Chi Y Nucifora G 《The Journal of biological chemistry》2001,276(48):44936-44943
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Gusterson RJ Jazrawi E Adcock IM Latchman DS 《The Journal of biological chemistry》2003,278(9):6838-6847
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