共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Murine nuclear factor of activated T cells (NFAT)2.alpha/beta differ by 42 and 28 unique amino-terminal amino acids and are differentially expressed. Both isoforms share conserved domains that regulate DNA-binding and subcellular localization. A genetic "one-hybrid" assay was used to define two distinct transactivation (TA) domains: in addition to a conserved TAD present in both isoforms, a second, novel TAD exists within the beta-specific amino terminus. Pharmacologic inhibitors G?6976 and rottlerin demonstrate that both conventional and novel protein kinase C (PKC) family members regulate endogenous mast cell NFAT activity, and NFAT2 TA. Overexpression of dominant active PKC (which has been implicated in immune receptor signaling) induces NFAT2.alpha/beta TA. Mutations within the smallest PKC-responsive transactivation domain demonstrate that the PKC effect is at least partially indirect. Significantly, the beta-specific domain confers greater ability to TA in response to treatment with phorbol 12-myristate 13-acetate/ionomycin or lipopolysaccharide, and unique sensitivity to FcepsilonRI signaling. Accordingly, overexpression of NFAT2.beta results in significantly greater NFAT- and interleukin-4 reporter activity than NFAT2.alpha. These results suggest that whereas NFAT2 isoforms may share redundant DNA-binding preferences, there are specialized functional consequences of their isoform-specific domains. 相似文献
12.
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase 总被引:13,自引:0,他引:13
Kirsh O Seeler JS Pichler A Gast A Müller S Miska E Mathieu M Harel-Bellan A Kouzarides T Melchior F Dejean A 《The EMBO journal》2002,21(11):2682-2691
13.
14.
15.
16.
17.
18.
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1 总被引:7,自引:0,他引:7
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hietakangas V Ahlskog JK Jakobsson AM Hellesuo M Sahlberg NM Holmberg CI Mikhailov A Palvimo JJ Pirkkala L Sistonen L 《Molecular and cellular biology》2003,23(8):2953-2968
19.
20.
Arito M Horiba T Hachimura S Inoue J Sato R 《The Journal of biological chemistry》2008,283(22):15224-15231