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Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene. 总被引：11，自引：2，他引：9 
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下载免费PDF全文 H Takahashi Y Hakamata Y Watanabe R Kikuno T Miyata S Numa 《Nucleic acids research》1983,11(19):6847-6858
The nucleotide sequence of an 8658-base-pair human genomic DNA segment containing the entire corticotropin-beta-lipotropin precursor gene has been determined, and some sequence features of the gene and its flanking regions have been analysed. The gene is composed of 7665 base pairs including two introns of 3708 and 2886 base pairs. Comparison of the 5'-flanking sequences of the human, bovine and mouse corticotropin-beta-lipotropin precursor genes reveals the presence of a highly conserved region, which contains sequences of 14-15 base pairs homologous with sequences located upstream of the mRNA start site of other glucocorticoid-regulated genes. 相似文献
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J W Innis D J Moore S F Kash V Ramamurthy M Sawadogo R E Kellems 《The Journal of biological chemistry》1991,266(32):21765-21772
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细胞团子IL-1β可以诱导SH-SY5Y神经母细胞瘤细胞中APP基因的转录．为了研究APP基因启动子区的IL-1β反应元件,用含不同长度APP启动子片段的报告基因载体,瞬时转染SH-SY5Y细胞,发现APP启动子在SH-SY5Y细胞中有较强活性,其中-488到-303区为IL-1β诱导APP转录活性增加所必需,这个区域包括1个AP1结合位点和1个HSE元件． 相似文献