共查询到20条相似文献,搜索用时 10 毫秒
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Frankel AD 《Nature structural biology》1999,6(12):1081-1083
The structure of the yeast L30 ribosomal protein bound to its autoregulatory RNA site has been determined by NMR spectroscopy. The intricate architecture of the RNA internal loop and the structure of the binding region of the protein both are stabilized in the complex, highlighting the importance of mutually-induced fit in RNA-protein interactions. 相似文献
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Least-absolute-deviations fits for generalized linear models 总被引:1,自引:0,他引:1
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The modeling of biological wastewater treatment processes has received much attention over the past ten years. Efforts are underway to develop a unified model for these processes which will greatly aid in the design and operation of wastewater treatment facilities. This paper presents a philosophical discussion of model building strategies augmented by a discussion of statistical problems associated with model parameter estimation and model discrimination. This discussion further illustrates with actual data, that goodness of fit is not a sufficient condition for model acceptance. Numerous rival models are examined to illustrate this point. In order to verify a model or to discriminate between rival models, they must be “Put in jeopardy.” If this attitude is not employed in model building efforts, important discrepancies in the proposed model may go undetected. 相似文献
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S J Wallace 《BMJ (Clinical research ed.)》1976,1(6005):333-334
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K Sadhra 《BMJ (Clinical research ed.)》1984,288(6418):681-682
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BACKGROUND: Hissy fits are experienced by physicians and patients alike, yet their full impact has never been studied before. METHODS: Specially trained researchers observed hissy fits at a clinic over 12 months. They interviewed perpetrators, victims and witnesses and recorded their comments because they had to. RESULTS: Hissy fits were common at the clinic and sometimes escalated to riots. Seasonal variations were endured. INTERPRETATION: Nobody likes this behaviour. Efforts should be made to counsel hissy fitters in channeling their angst in other, more positive ways. 相似文献
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RAGE: a single receptor fits multiple ligands 总被引:1,自引:0,他引:1
Fritz G 《Trends in biochemical sciences》2011,36(12):625-632
The receptor for advanced glycation end products (RAGE) is a central signaling molecule in the innate immune system and is involved in the onset and sustainment of the inflammatory response. RAGE belongs to a class of pattern recognition receptors that recognize common features rather than a specific ligand. Recent structural information on the extracellular portion (ectodomain) of RAGE shed new light on this unusual ability. X-ray crystallographic, NMR and biochemical data suggest that ligand binding is driven largely by electrostatic interactions between the positively charged surface of the ectodomain and negatively charged ligands. In this article, I propose a putative mechanism of RAGE ligand recognition of receptor activation. 相似文献
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In this paper, we introduce a novel simplification method for dealing with physical systems that can be thought to consist of two subsystems connected in series, such as a neuron and a synapse. The aim of our method is to help find a simple, yet convincing model of the full cascade-connected system, assuming that a satisfactory model of one of the subsystems, e.g., the neuron, is already given. Our method allows us to validate a candidate model of the full cascade against data at a finer scale. In our main example, we apply our method to part of the squid’s giant fiber system. We first postulate a simple, hypothetical model of cell-to-cell signaling based on the squid’s escape response. Then, given a FitzHugh-type neuron model, we derive the verifiable model of the squid giant synapse that this hypothesis implies. We show that the derived synapse model accurately reproduces synaptic recordings, hence lending support to the postulated, simple model of cell-to-cell signaling, which thus, in turn, can be used as a basic building block for network models. 相似文献
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An innovative procedure of genome-wide association analysis fits studies on germplasm population and plant breeding 总被引:6,自引:0,他引:6
Jianbo He Shan Meng Tuanjie Zhao Guangnan Xing Shouping Yang Yan Li Rongzhan Guan Jiangjie Lu Yufeng Wang Qiuju Xia Bing Yang Junyi Gai 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2017,130(11):2327-2343