共查询到20条相似文献,搜索用时 15 毫秒
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Jue-Liang Hsu Lan-Yu Wang Shu-Ying Wang Ching-Huang Lin Kuo-Chieh Ho Fong-Ku Shi Ing-Feng Chang 《Proteome science》2009,7(1):42
Background
Under conditions of salt stress, plants respond by initiating phosphorylation cascades. Many key phosphorylation events occur at the membrane. However, to date only limited sites have been identified that are phosphorylated in response to salt stress in plants. 相似文献2.
Background
Insects have an efficient self-defense system that is based on innate immunity. Recent findings have disclosed many parallels between human and insect innate immunity, and simultaneously fine differences in the processes between various species have been revealed. Studies on the immune systems of various insect species may uncover the differences in their host defense strategies. 相似文献3.
Thomas A Hawkins Florencia Cavodeassi Ferenc Erdélyi Gábor Szabó Zsolt Lele 《BMC developmental biology》2008,8(1):42
Background
Key molecules involved in notochord differentiation and function have been identified through genetic analysis in zebrafish and mice, but MEK1 and 2 have so far not been implicated in this process due to early lethality (Mek1-/-) and functional redundancy (Mek2-/-) in the knockout animals. 相似文献4.
Niels Rahe-Meyer Christian Weilbach Matthias Karst Matthias Pawlak Aminul Ahmed Siegfried Piepenbrock Michael Winterhalter 《Biomedical engineering online》2007,6(1):1
Background
Current devices for measuring muscle contraction in vivo have limited accuracy in establishing and re-establishing the optimum muscle length. They are variable in the reproducibility to determine the muscle contraction at this length, and often do not maintain precise conditions during the examination. Consequently, for clinical testing only semi-quantitative methods have been used. 相似文献5.
Background
DUX4 is causally involved in the molecular pathogenesis of the neuromuscular disorder facioscapulohumeral muscular dystrophy (FSHD). It has previously been proposed to have arisen by retrotransposition of DUXC, one of four known intron-containing DUX genes. Here, we investigate the evolutionary history of this multi-member double-homeobox gene family in eutherian mammals. 相似文献6.
Michael Tillich Vinh Le Sy Katrin Schulerowitz Arndt Haeseler von Uwe G Maier Christian Schmitz-Linneweber 《BMC evolutionary biology》2009,9(1):201
Background
RNA editing in chloroplasts of angiosperms proceeds by C-to-U conversions at specific sites. Nuclear-encoded factors are required for the recognition of cis -elements located immediately upstream of editing sites. The ensemble of editing sites in a chloroplast genome differs widely between species, and editing sites are thought to evolve rapidly. However, large-scale analyses of the evolution of individual editing sites have not yet been undertaken. 相似文献7.
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Background
The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream of Rac activation and as members of large protein complexes. 相似文献9.
Hui-Hsien Chou Arunee Trisiriroj Sunyoung Park Yue-Ie C Hsing Pamela C Ronald Patrick S Schnable 《BMC bioinformatics》2009,10(1):347
Background
Few microarrays have been quantitatively calibrated to identify optimal hybridization conditions because it is difficult to precisely determine the hybridization characteristics of a microarray using biologically variable cDNA samples. 相似文献10.
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Lisa Bruns Oliver Frey Lars Morawietz Christiane Landgraf Rudolf Volkmer Thomas Kamradt 《Arthritis research & therapy》2009,11(4):R117
Introduction
T-helper (Th) lymphocytes are critically required for the pathogenesis of glucose-6-phosphate isomerase (G6PI)-induced arthritis, but neither the G6PI epitopes recognized by arthritogenic T cells nor their pathogenic effector functions have been fully elucidated to date. We aimed at identifying arthritogenic G6PI peptides. 相似文献12.
Background
Many sequenced bacterial genomes harbor phage-like elements or cryptic prophages. These elements have been implicated in pathogenesis, serotype conversion and phage immunity. The e14 element is a defective lambdoid prophage element present at 25 min in the E. coli K-12 genome. This prophage encodes important functional genes such as lit (T4 exclusion), mcrA (modified cytosine restriction activity) and pin (recombinase). 相似文献13.
Background
Although Aspergillus fumigatus is an important human fungal pathogen there are few expression systems available to study the contribution of specific genes to the growth and virulence of this opportunistic mould. Regulatable promoter systems based upon prokaryotic regulatory elements in the E. coli tetracycline-resistance operon have been successfully used to manipulate gene expression in several organisms, including mice, flies, plants, and yeast. However, the system has not yet been adapted for Aspergillus spp. 相似文献14.
Background
The roles of the Hedgehog (Hh) pathway in controlling vertebrate retinal development have been studied extensively; however, species- and context-dependent findings have provided differing conclusions. Hh signaling has been shown to control both population size and cell cycle kinetics of proliferating retinal progenitors, and to modulate differentiation within the retina by regulating the timing of cell cycle exit. While cell cycle exit has in turn been shown to control cell fate decisions within the retina, a direct role for the Hh pathway in retinal cell fate decisions has yet to be established in vivo. 相似文献15.
Alessandro Paiardini Riccardo Sali Francesco Bossa Stefano Pascarella 《BMC structural biology》2008,8(1):14
Background
A wide variety of stabilizing factors have been invoked so far to elucidate the structural basis of protein thermostability. These include, amongst the others, a higher number of ion-pairs interactions and hydrogen bonds, together with a better packing of hydrophobic residues. It has been frequently observed that packing of hydrophobic side chains is improved in hyperthermophilic proteins, when compared to their mesophilic counterparts. In this work, protein crystal structures from hyper/thermophilic organisms and their mesophilic homologs have been compared, in order to quantify the difference of apolar contact area and to assess the role played by the hydrophobic contacts in the stabilization of the protein core, at high temperatures. 相似文献16.
Manuela Sironi Giorgia Menozzi Giacomo P Comi Matteo Cereda Rachele Cagliani Nereo Bresolin Uberto Pozzoli 《Genome biology》2007,7(12):R120
Background
Transposable elements (TEs) represent more than 45% of the human and mouse genomes. Both parasitic and mutualistic features have been shown to apply to the host-TE relationship but a comprehensive scenario of the forces driving TE fixation within mammalian genes is still missing. 相似文献17.
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Qian-Hao Zhu Mohammad Shamsul Hoque Elizabeth S Dennis Narayana M Upadhyaya 《BMC plant biology》2003,3(1):6