共查询到20条相似文献,搜索用时 15 毫秒
1.
H. Ranjith W. Dharmaratne Subramaniam Sotheeswaran Sinnathamby Balasubramaniam 《Phytochemistry》1984,23(11):2601-2603
The petrol extracts of the leaves of Calophyllum lankaensis and C. thwaitesii yielded D:A-friedo-oleanan-3-one, 28-hydroxy-D:A-friedo-oleanan-3-one (canophyllol), 28-oxo-D:A-friedo-oleanan-3-one (canophyllal calozeylanic acid, thwaitesic acid, isothwaitesic acid and apetalactone. Thwaitesic acid and iso-thwaitesic acid are two novel neoflavonoids. 相似文献
2.
Three new D:A friedo-oleanane triterpenes, 3α-p-coumaroyl-D:A-friedo-oleanan-27-oic acid (1), 3α-(3,4-dihydroxycinnamoyl)-D:A-friedo-oleanan-27-oic acid (2), and 3α-(3,4-dihydroxycinnamoyl)-D:A-friedo-oleanan-27,15α-lactone (3) along with three known compounds, trichadenic acid A (4), trichadonic acid (5), and amentoflavone (6), were isolated from the stem barks of Anacolosa poilanei Gagnep. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, and 2D-NMR. Compound 1 exhibited cytotoxicity against LU-1, HepG2, MCF7, and KB cell lines. Compounds 2 and 3 were more active against KB and HepG2 compared to the LU-1 and MCF7 cells. 相似文献
3.
《Journal of Fermentation and Bioengineering》1991,71(3):176-180
Fusarium avenaceum f. sp. fabae IFO 7158 metabolized tricaprin with accumulation of n-nonane-2-one and three unknown minor compounds in the medium. The three compounds were identified to be 8-hydroxy-n-nonane-2-one, 7-hydroxy-n-nonane-2-one, and 6-hydroxy-n-nonane-2-one. The accumulation of the monohydroxy-n-nonane-2-ones took place with a decrease in n-nonane-2-one (C9:0-2-one) once formed from capric acid (C10:0). Thus, it is speculated that hydroxylations of n-nonane-2-one at ω2, ω3, and ω4 carbons gave the 8-hydroxy-, 7-hydroxy-, and 6-hydroxy-n-nonane-2-ones, respectively. Even though the microorganism could utilize well for growth all of the synthetic triglycerides, such as tricaproin, tricaprylin, tricaprin, trilaurin, trimyristin, and tripalmitin, the monohydroxy-n-alkane-2-one was formed exclusively from tricaprin. The maximal accumulation of monohydroxy-n-nonane-2-ones, a mixture of 8-hydroxy-, 7-hydroxy- and 6-hydroxy-n-nonane-2-ones in an approximate ratio of 10:7:0.5, was 139 mg from 1.0 g tricaprin. Finally, a novel metabolic pathway for the medium chain fatty acid in the fungus is discussed. 相似文献
4.
《Phytochemistry》1999,52(5):947-955
Thirteen homoisoflavonoids, nine of which are new: 3-(4-methoxybenzyl)-5,7-dimethoxychroman-4-one, 3-(4-hydroxy-3-methoxybenzyl)-5-hydroxy-7-methoxychroman-4-one, 3-(4-methoxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one, 3-(4-hydroxybenzylidene)-5-hydroxy-7-methoxychroman-4-one, 3-(4-hydroxy-3-methoxybenzyl)-5-hydroxy-6,7-dimethoxychroman-4-one, 3-(3,4-dimethoxybenzyl)-5,7-dihydroxychroman-4-one, 3-(4-methoxybenzyl)-6-hydroxy-5,7-dimethoxychroman-4-one, 3-(4-hydroxybenzyl)-5,6,7-trimethoxychroman-4-one and 3-(4-methoxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one, were isolated from the bulbs of Scilla nervosa together with four known ones and three known stilbene derivatives. The structures of these secondary metabolites were characterized by spectroscopic means and by comparison with published information for known compounds. 相似文献
5.
C. Betancor R. Freire A.G. Gonzalez J.A. Salazar C. Pascard T. Prange 《Phytochemistry》1980,19(9):1989-1993
The investigation of stems and leaves of Catha cassinoides afforded, in addition to sitosterol, β-amyrin, ursolic acid, lup-20(29)-en-3β,30-diol and friedelin, three new pentacyclic triterpenes: 30-hydroxyfriedelan-3-one, 29-hydroxyfriedelan-3-one and 3-oxo-friedelan-29-oic acid. The structures ofthese were determined by spectral studies and correlations, and were confirmed by X-ray analysis of 29-hydroxyfriedelan-3-one acetate. 相似文献
6.
The increasing life expectancy in our population makes Parkinson’s disease (PD) a growing public health problem. There is a great need to find a way to prevent and delay the disease. It was shown that selective phosphodiesterase 1 (PDE1) inhibitors and anti-inflammatory agents might be effective in treating PD. Therefore, a novel 1,2,9,11-tetrasubstituted-7H-thieno[2′,3′:4,5]pyrimido[6,1-b]-quinazolin-7-one (1–15) and 1,3,10,12-tetrasubstituted-8H-pyrido[2′,3′:4,5]pyrimido[6,1-b]quinazolin-8-one (16–36) derivatives were synthesized by reported method and investigated for their ability to inhibit PDE1. Most of the synthesized compounds have shown good activity against PDE1 and were less effective than 3-isobutyl-1-methylxanthine. All the compounds were also tested for their in vitro anti-inflammatory activity by carrageenan-induced oedema in rats. In addition, ulcerogenic activity was determined. The combined anti-inflammatory data from in vitro animal model showed that compounds, 9,11-dibromo-1-(2-furyl)-3-(4-tolyl)-8H-pyrido[2′,3′:4,5]pyrimido[6,1-b]quinazolin-8-one 23, 9,11-dibromo-1-(4-methoxy-phenyl)-3-phenyl-8H-pyrido[2′,3′:4,5]pyrimido[6,1-b]quinazolin-8-one 24, 9,11-dibromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2′,3′:4,5]pyrimido[6,1-b]quinazolin-8-one 29 and 9-bromo-1-(4-chloro-phenyl)-3-(4-tolyl)-8H-pyrido[2′,3′:4,5]pyrimido[6,1-b]quinazolin-8-one 36 exhibited even more potent anti-inflammatory activity and low gastric ulceration incidence compare to reference standard Indomethacin. Since compound 23, 24, 29 and 36 exhibits both anti-inflammatory activity and PDE1 inhibition, it needs further detailed studies. 相似文献
7.
Jian Huang Zheng-hong Guo Peng Cheng Bo-hang Sun Hui-Yuan Gao 《Phytochemistry letters》2012,5(3):432-437
To identify the chemical constituents with hypoglycemic activity in Salacia hainanensis Chun et How, this study was carried out on the roots of S. hainanensis. By means of a bioassay-guided method, three new triterpenoids (2β,3β-dihydroxylup-20(29)-ene [compound 1], 30-hydroxy-D:A-friedo-olean-1-en-3-one [compound 2], and 24,25,26-trihydroxytirucall-7-en-3-one [compound 3]) along with three known compounds (olibanumol J [compound 4], 21α-hydroxy-D:A-friedo-olean-3-one [compound 5], and 29-hydroxy-D:A-friedo-olean-3-one [compound 6]) were isolated from the EtOAc part and were shown to have effective α-glucosidase inhibitory activity. Their structures were established on the basis of spectral analysis, especially according to the data obtained by two dimensional nuclear magnetic resonance spectroscopic and high-resolution mass spectra experiments. All compounds with the exception of compound 2 showed much stronger inhibitory activity against α-glucosidase than did the positive control (acarbose, IC50 1.02 μM). 相似文献
8.
From the extract of the fruits of Solanum xanthocarpum (Solanaceae), five new steroidal compounds were isolated and characterized: 4α-methyl-24ξ-ethyl-5α-cholest-7-en-3β,22ξ-diol (1), 3β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (2), 3β-benzoxy-14β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (3), 3β-benzoxy-14α,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (4) and 3β-(p-hydroxy)-benzoxy-22ξ-hydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (5). 相似文献
9.
[4 -14C]-Progesterone was applied to the leaves of growing pea plants, Pisum sativum. After 3 weeks, about 50% of the administered steroid was reduced, about 20% being reduced to 5α-pregnane-3α,20β-diol as the major metabolite. The radioactivities of 5α-pregnane-3α,20α-diol and 5α-pregnane-3α,20β-diol after 3 weeks were more than twice those after one week. The following radioactive metabolises were also isolated: 5α-pregnane-3,20-dione; 20α-hydroxy-4- pregnen-3-one; 20β-hydroxy-4-pregnen-3-one; 3α-hydroxy-5α-pregnan-20-one; 3α-hydroxy-5β-pregnan-20-one; 3β-hydroxy- 5α-pregnan-20-one; 20β-hydroxy-5α-pregnan-3-one; 5α-pregnane-3β,20β-diol; and 5β-pregnane-3α,20β-diol. The radioactivities of the 5α-pregnane derivatives were considerably higher than those of the corresponding 5β-pregnane derivatives. 相似文献
10.
Estrogen-primed female rats were administered progesterone, 5 a-pregnan-3,20-dione, 5a-pregnan-3a-ol-20-one, 5a-pregnan-3β-ol-20-one, 4-pregnen-20a-ol-3-one, and 5a-pregnan-20a-ol-3-one in oil or oil alone and tested for the display of lordosis behavior 3 and 5 hr after progestin treatment. Progesterone was the most effective progestin in facilitating lordosis behavior. 5a-Pregnan- 3,20-dione and 5a-pregnan-3a-ol-20-one were partially effective, while the other progestins were no more effective than oil. The data suggest that the neuronal system which controls lordosis behavior is not entirely specific for progesterone. 相似文献
11.
E. A. Piir G. E. Morozevich F. V. Drozdov V. P. Timofeev A. Yu. Misharin 《Russian Journal of Bioorganic Chemistry》2006,32(5):497-503
(22E)-3β-Hydroxysitosta-5,22-dien-7-one, (22R,23R)-3β,22,23-trihydroxysitost-5-en-7-one, and (22R,23R)-3β-hydroxy-22,23-isopropylidenedioxysitost-5-en-7-one were synthesized. The cytotoxicity and effects on cholesterol biosynthesis of the resulting 7-ketosterols, 7-ketocholesterol, and (22S,23S)-3β-hydroxy-22,23-oxidositost-5-en-7-one were studied in hepatoblastoma Hep G2 cells. 相似文献
12.
《Bioorganic & medicinal chemistry letters》2014,24(5):1358-1361
A new cytotoxic β-carboline alkaloid, 1-methyl-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)-cyclopentanol (1), was isolated from roots of Galianthe thalictroides, together with the alkaloid 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)-cyclopentanol (2), the anthraquinones 1-methyl-alizarin and morindaparvin-A, the coumarin scopoletin, homovanillic alcohol, (−)-epicatechin, and the steroids stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, 6-β-hydroxy-stigmast-4-en-3-one, stigmasterol, campesterol, β-sitosterol, and β-sitosterol-3-O-β-d-glucopyranoside. Among the previously known compounds, homovanillic alcohol is a novel finding in Rubiaceae, while 1-methyl-alizarin, morindaparvin-A, scopoletin, stigmast-4-en-3-one, 4,22-stigmastadien-3-one, campest-4-en-3-one, stigmast-4-en-3,6-dione, and 6-β-hydroxy-stigmast-4-en-3-one is reported for the first time in the genus Galianthe. The cytotoxic β-carboline alkaloids 1 and 2 exhibited potent antitopoisomerase I and IIα activities and strong evidence is provided for their action as topoisomerase IIα poisons and redox-independent inhibitors. 相似文献
13.
Samson O. Famuyiwa Kwenga F. Sichilongo Samuel O. Yeboah Berhanu M. Abegaz 《Phytochemistry letters》2012,5(3):591-595
Eight homoisoflavonoids, two of which are new: 3-(4′-methoxybenzyl)-5,6,7-trimethoxychroman-4-one (1); 3-(4′-methoxybenzyl)-5,7-dimethoxychroman-4-one (2); 3-(4′-methoxybenzyl)-7-hydroxy-5,6-dimethoxychroman-4-one (3); 3-(4′-methoxybenzyl)-6-hydroxy-5,7-dimethoxychroman-4-one (4); 3-(3′-hydroxy-4′-methoxybenzyl)-5,7-dihydroxy-6-methoxychroman-4-one (5); 3-(3′-hydroxy-4′-methoxybenzyl)-5,7-dihydroxychroman-4-one (6); 3-(4′-hydroxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one (7) and 3-(4′-hydroxybenzylidene)-5,7-dihydroxychroman-4-one (8), were isolated from the yellow Inter-bulb deposits from Scilla nervosa. The structures of these compounds were elucidated and characterized by 1D- and 2D-NMR and mass spectrometry. The structures of the known compounds were compared to those ones in literature. 相似文献
14.
The isolation of six known and two new D:A-friedooleananes is reported from the bark of Elaeodendron glaucum. The structures of the new nor-triterpenes, elaeodendrol and elaeodendradiol, were established respectively as 17β- hydroxy-28-norfriedelan-3-one and l7β,25-dihydroxy-28-norfriedelan-3-one by a study of the methyl chemical shifts in their 1H NMR spectra. 相似文献
15.
Francisco García Gonzalez Manuel Gómez Guillén Juan A. Galbis Pérez Emilio Román Galán 《Carbohydrate research》1980,80(1):37-43
Acid-catalysed dehydration of the polyhydroxyalkyl chain of 6,6-dimethyl-2-(d-gluco-pentitol-l-yl)-4,5,6,7-tetrahydroindol-4-one and of 6,6-dimethyl-2-(d-manno-pentitol-l-yl)-4,5,6,7-tetrahydroindol-4-one gave 2-α-d-arabinofuranosyl-6,6-dimethyl-4,5,6,7-tetrahydroindol-4-one (3). In a similar way, 2-β-d-lyxopyranosyl-6,6-dimethyl-4,5,6,7-tetrahydroindol-4-one (8) and 2-β-d-lyxopyranosyl-4,5,6,7-tetrahydroindol-4-one (9) were obtained by dehydration of 6,6-dimethyl-2-(d-galacto-pentitol-l-yl)-4,5,6,7-tetrahydroindol-4-one and 2-(d-galacto-pentitol-l-yl)-4,5,6,7-tetrahydroindol-4-one, respectively. The structures of the new C-nucleosides described (3, 8, and 9) were elucidated by chemical and physical methods. 相似文献
16.
Heating of D-glucose with diethylammonium tartrate to about 130° gave a dark-brown reaction mixture from which 3,5- dihydroxy-6-mothyl-2H-pyran-2-one and the cyclic amino reductones were isolated. The major amino reductone 4-(diethylamino)-1,3-dihydroxy-1-methyl-3-cyclopenten-2-one was determined by g.l.c. after treatment with methanol-p-toluenesulfonic acid to give 3-hydroxy-1,4-dimethoxy-1-methyl-3-cyclopenten-2-one and 1,3,4-trimethoxy-1-methyl-3-cyclopenten-2-one. 相似文献
17.
《Journal of steroid biochemistry》1976,7(5):377-379
Human cornea excised from patients with wounded eyes were incubated in vitro for a 5-day period in the presence of [4-14C]-progesterone. The following C21 steroid metabolites were identified by paper chromatography, derivative formation, and crystallizations to specific activities: 20α-hydroxy-4-pregnen-3-one, 20β-hydroxy-4-pregnen-3-one, and 5α-pregnan-3,20-dione. 相似文献
18.
A.A. Leslie Gunatilaka N.P. Dhammika Nanayakkara M. Uvais S. Sultanbawa Sinnathamby Balasubramaniam 《Phytochemistry》1982,21(8):2061-2063
Three triterpenes obtained from the inner bark of Kokoona zeylanica have been identified as friedelin, D:A-friedo-olean-3, 21-dione and 21α-hydroxy- D:A-friedo-olean-3-one by spectroscopic properties and chemical interconversions. Their chemotaxonomic significance is emphasized. 相似文献
19.
Wickramasinghe M. Bandaranayake 《Phytochemistry》1980,19(2):255-257
The following terpenoids were identified in the oleoresin, bark and timber of Canarium zeylanicum: 3β-hydroxyurs-12-en-11-one, 3β-hydroxyolean-12-en-11-one, olean-12-en-3,11-dione, urs-12-en-3,11-dione, α- and β-amyrin, α- and β-amyrenone, taraxerol, sitosterol, canaric acid, elemene, elemol, α-pinene, α- and β-phellandrene, limonene, terpineol and carvone. 相似文献
20.
A phenanthrene derivative, aristololactam N-β-d-glucoside, and the steroids 3β-hydroxy-stigmast-5-en-7-one and 6β-hydroxy-stigmast-4-en-3-one have been isolated from Aristolochia indica. 相似文献