促性腺激素释放激素的种类,作用及调节

促性腺激素释放激素的种类、作用及调节禹龙香李远友（湖南农业大学医院,长沙４１０１２８）（中山大学生物系,广州５１０２７５）促性腺激素释放激素（ＧｎＲＨ）是由脊椎动物的脑（主要是视前—下丘脑）产生的一类十肽激素,它在脑垂体促性腺激素（ＧｔＨ）的合成和分...     

神经内分泌讲座（三）：———促性腺激素释放激素

１概述对促性腺激素释放激素（ＧｎＲＨ）的研究始于６０年代初,当时哈里斯（Ｈａｒｒｉｓ）将动物下丘脑提取物注入家兔或鼠的腺垂体时,可以引起促黄体生成素（ＬＨ）的分泌并发生排卵。体外垂体培养时加入这种提取物可使培养液中的ＬＨ和促卵泡生成激素（ＦＳＨ）浓度...     

蛙类下丘脑—脑垂体—性腺轴的内分泌调节

本文从“下丘脑－脑垂本－性腺”轴方面,综述了蛙类生殖内分泌学研究领域所限得的主要成就和研究进展。对于今后的工作,从理论和生产方面提出了一些看法。     

促性腺激素释放激素受体及其基因表达调控

促性腺激素释放激素（ＧｎＲＨ,ＬＨＲＨ）在体内的重要功能是由ＧｎＲＨ受体介导的。ＧｎＲＨ受体是近年神经分内分泌和生殖生物学研究的热点之一,本文从ＧｎＲＨ受体的分子结构,ＧｎＲＨ受体基因表达调控,ＧｎＲＨ受体分布及表达,调节ＲｎＲＨ受体的因素以及ＧｎＲＨ受体介导的细胞信号转导等几个方面对ＧｎＲＨ受体近年来的研究进展进行了综述,对ＧｎＲＨ受体的研究,将有助于人们进一步了解ＧｎＲＨ受体在生殖调节和恶性肿     

脊椎动物促性腺激素释放激素的分子结构变异型和功能多样性

综述了近十几年来有关对脊椎动物促性腺激素释放激素的结构和功能的研究进展,阐明促性腺激素释放激素分子结构的变异型和它们在脊椎动物的分布和进化,分析促性腺激素释放激素的多种功能及其受体的结构与特异性。     

大鼠颌下腺促性腺激素释放激素及其mRNA的免疫组织化学与原位杂交 …

用免疫组织化学及原位杂交法,研究了促性腺激素释放激素及其ｍＲＮＡ在大鼠颌下腺的分布。结果显示,大鼠颌下腺的浆液腺泡的上皮细胞,各级导和的上皮细胞及副交感神经节细胞均呈促性腺激素释和激素免疫反应阳性,阳生反应物质分布在胞质,胞核呈阴性反应。     

Preliminary Studies on Controlling Graft Union Through Plant Hormones

The influences of IBA and 6-BA on the formation of grafting were studied by using explanted internode autografting of cucumber (Cucumis sativus) cultured in vitro, which was a simpler procedure for grafting with lower chance of contamination than the ordinary explanted internode grafting. Colour changes, root initiation and callus formation of the explanted internode graf related to the concentration of plant hormones added to the medium. Plant hormones controlled the formation of graft unions through influencing the time and the number of vascular bridges formation between the stock and the scion. In authors experiments, the optimal condition of plant hormone control was achieved when IBA 1.2 mg/L was added in the scion medium and 6-BA 0.3 mg/L was added to scion and stock medium.     

Character Displacement in Frogs

Additional evidence has accumulated over the past 20 years regardingthe significance of the anuran mating call and regarding reinforcementof this premating isolating mechanism when hybridization occursin zones of symnatry. No two sympatric species have the samecall. That the mating call is a home-specific mate attractanthas been demonstrated in five major anuran families. Discriminationagainst hybrid calls versus homospecific calls has been demonstratedin Bufo and Hyla. Principal examples of presumed reinforcementcontinue to be in Gastrophryne, Acris, and the Australian Hylaewingi group. Reinforcement may be the basis for striking differentiationof some populations of Scaphiopus bombifrons. Sympatric speciespairs of anurans show greater differentiation in call than doallopatric pairs in the same group. One hybridizing situationin Bufo appears to have changed over 30 years to discrete populationswithout intermediate calls. Effective call differences can evolvewithout sympatry, and there are sympatric situations in whichno reinforcement is evident.     

促性腺激素释放激素激动剂治疗子宫内膜异位症的临床疗效观察

目的:探讨促性腺激素释放激素激动剂(GnRH-a)治疗子宫内膜异位症的临床疗效.方法:将2007年8月～2012年1月本医务室收治的102例教师子宫内膜异位症患者随机分为三组,其中50例行GnRH-a加反向添加法治疗(Ⅰ组),28例行GnRH-a退缩疗法(Ⅱ组),24例作为对照组(Ⅲ组),对比三组治疗的临床疗效、垂体-卵巢轴内分泌变化及副反应.结果:Ⅰ组和Ⅱ组的治疗总有效率分别为96.0％和85.7％,均明显高于Ⅲ组(75.0％,P＜0.05).Ⅰ组和Ⅱ组治疗后患者的血清E2、FSH、LH、P的水平较治疗前均明显下降(P均＜0.05),Ⅰ组和Ⅱ组之间治疗有效率及治疗后血清E2、FSH、LH、P的水平均无明显差异(P均＞0.05),且三组治疗前后骨密度均无显著变化,治疗后三组之间骨密度亦无明显差异(P均＞0.05).结论:运用GnRH-a加反向添加法或退缩疗法治疗子宫内膜异位症,可显著改善患者的内分泌功能,临床效果明显优于常规处理,且副作用较小,值得临床推广应用.     

Effects of Gonadotropin-Releasing Hormone Analogue Surfagon on Pain Sensitivity in Rats

Journal of Evolutionary Biochemistry and Physiology - We investigated the effects of the synthetic gonadotropin-releasing hormone agonistic analogue surfagon on the spinal and supraspinal mechnisms...     

Ultrastructure of Cytotoxic Cells in Frogs

Our previous work gave evidence that leopard frogs ( Rana pipiens ) possess inducible killer (IK) cells (CTL-like) and spontaneous killer (SK) cells (NK-like) that can destroy allogeneic RBC. To further characterize these cytotoxic cells we have examined their ultrastructural morphology and effector cell-target cell membrane contacts. We also studied the sensitivity of these two effector cells to low temperature (4°C). Our results showed that SK effector cells are lymphocytes (10 μm) which contain numerous vacuoles and osmiophilic granules, while IK effectors are another lymphocyte population (up to 12 μm) with a small amount of cytoplasm and few mitochondria. Both IK- and SK-mediated lytic responses were suppressed significantly by low temperature. These observations allow us to propose that frog SK and IK cells may be homologous to mammalian NK and CTL.