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1.
LTR (long terminal repeat) retrotransposons are the main components of higher plant genomic DNA. They have shaped their host genomes through insertional mutagenesis and by effects on genome size, gene expression and recombination. These Class I transposable elements are closely related to retroviruses such as the HIV by their structure and presumptive life cycle. However, the retrotransposon life cycle has been closely investigated in few systems. For retroviruses and retrotransposons, individual defective copies can parasitize the activity of functional ones. However, some LTR retrotransposon groups as a whole, such as large retrotransposon derivatives and terminal repeats in miniature, are non-autonomous even though their genomic insertion patterns remain polymorphic between organismal accessions. Here, we examine what is known of the retrotransposon life cycle in plants, and in that context discuss the role of parasitism and complementation between and within retrotransposon groups. 相似文献
2.
Barbara K. Mable Sarah P. Otto 《BioEssays : news and reviews in molecular, cellular and developmental biology》1998,20(6):453-462
Sexual eukaryotic organisms are characterized by an alternation between haploid and diploid phases. In vascular plants and animals, somatic growth and development occur primarily in the diploid phase, with the haploid phase reduced to the gametic cells. In many other eukaryotes, however, growth and development occur in both phases, with substantial variability among organisms in the length of each phase of the life cycle. A number of theoretical models and experimental studies have shed light on factors that may influence life cycle evolution, yet we remain far from a complete understanding of the diversity of life cycles observed in nature. In this paper we review the current state of knowledge in this field, and touch upon the many questions that remain unanswered. BioEssays 20 :453–462, 1998. © 1998 John Wiley & Sons, Inc. 相似文献
3.
The life cycle of Podocoryne carnea (Coelenterata, Anthomedusae) shows several distinct stages which differ considerably in terms of their ecology, morphology, cellular composition, and ultrastructure. Previously these stages had even been described as separate species. Using two-dimensional gel electrophoresis and a new method of double-label autoradiography, we show here for the first time for metagenic hydrozoans that only minor differences in gene expression exist between the various life cycle stages. Our results demonstrate the high resolution power of these techniques and show that the different life stages of P. carnea remain rather similar on the protein level. Most of the prominent spots of the two-dimensional gel protein patterns are common to all stages studied. These data show that the hydrozoan life cycle and development are regulated by only minor distinctions in gene expression which possibly explains the great morphogenetic repertoire of these animals described in many studies. 相似文献
4.
Naturalists and scientists have been captivated by the diversity of marine larval forms since they were discovered following the advent of the microscope. Because they often bear little resemblance to adults, larvae were identified initially as new life forms, classified into different groups based on the similarity of their body plans and given new names that are still with us today. The radically different body plans and lifestyles of marine larvae and adults have led most investigators historically to study the two phases of complex life cycles in isolation. More recently, important ecological insights have sprung from taking a holistic view of marine life cycles. Meanwhile, the evolutionary (phenotypic and genetic) links among life-history phases remain less appreciated. In this review, our objective is to evaluate the evolutionary links within marine life cycles, and explore their ecological and evolutionary consequences. We provide a brief overview of marine life histories, discuss the phenotypic and genetic links between the two phases of the life cycle and pose challenges to advance our understanding of the evolutionary constraints acting on marine life histories. 相似文献
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6.
Norihiro Itsubo Masaji Sakagami Koichi Kuriyama Atsushi Inaba 《The International Journal of Life Cycle Assessment》2012,17(4):488-498
Purpose
Weighting is one of the steps involved in life cycle impact assessment (LCIA). This enables us to integrate various environmental impacts and facilitates the interpretation of environmental information. Many different weighting methodologies have already been proposed, and the results of many case studies with a single index have been published. However, a number of problems still remain. Weighting factors should be based on the preferences of society as a whole so that the life cycle assessment (LCA) practitioner can successfully apply them to every product and service. However, most existing studies do not really measure national averages but only the average of the responses obtained from the people actually sampled. Measuring the degree of uncertainty in LCIA factors is, therefore, one of the most important issues in current LCIA research, and some advanced LCIA methods have tried to deal with the problem of uncertainty. However, few weighting methods take into account the variability between each individual’s environmental thoughts. LIME2, the updated version of life cycle impact assessment method based on endpoint modeling (LIME), has been developed as part of the second LCA national project of Japan. One of the aims of LIME2 is to develop new weighting factors which fulfill the following requirements: (1) to accurately represent the environmental attitudes of the Japanese public, (2) to measure the variability between each individual’s environmental thoughts and reflect them in the choice of suitable weighting factors. 相似文献7.
8.
《Biochimica et Biophysica Acta - Proteins and Proteomics》2020,1868(8):140441
Dengue represents a substantial public health burden, particularly in low-resource countries. Non-structural protein 3 (NS3) is a multifunctional protein critical in the virus life cycle and has been identified as a promising anti-viral drug target. Despite recent crystallographic studies of the NS3 helicase domain, only subtle structural nucleotide-dependent differences have been identified, such that its coupled ATPase and helicase activities remain mechanistically unclear. Here we use molecular dynamics simulations to explore the nucleotide-dependent conformational landscape of the Dengue virus NS3 helicase and identify substantial changes in the protein flexibility during the ATP hydrolysis cycle. We relate these changes to the RNA-protein interactions and proposed translocation models for other monomeric helicases. Furthermore, we report a novel open-loop conformation with a likely escape route for Pi after hydrolysis, providing new insight into the conformational changes that underlie the ATPase activity of NS3. 相似文献
9.
Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy 总被引:1,自引:1,他引:0
The mechanisms underlying hepatitis C virus (HCV) morphogenesis remain elusive, but lipid droplets have recently been shown to be important organelles for virus production. We investigated the interaction between HCV-like particles and lipid droplets by three-dimensional reconstructions of serial ultrathin electron microscopy sections of cells producing the HCV core protein. The budding of HCV-like particles was mostly initiated at membranes close to the lipid droplets rather than at membranes directly apposed to the lipid droplets. This may have important implications for our understanding of the complex relationship between HCV and lipids and may make easier to dissect out the HCV life cycle. 相似文献
10.
Patterns of phenotypic evolution can abruptly shift as species move between adaptive zones. Extant salamanders display three distinct life cycle strategies that range from aquatic to terrestrial (biphasic), to fully aquatic (paedomorphic) and to fully terrestrial (direct development). Life cycle variation is associated with changes in body form such as loss of digits, limb reduction or body elongation. However, the relationships among these traits and life cycle strategy remain unresolved. Here, we use a Bayesian modelling approach to test whether life cycle transitions by salamanders have influenced rates, optima and integration of primary locomotory structures (limbs and trunk). We show that paedomorphic salamanders have elevated rates of limb evolution with optima shifted towards smaller size and fewer digits compared to all other salamanders. Rate of hindlimb digit evolution is shown to decrease in a gradient as life cycles become more terrestrial. Paedomorphs have a higher correlation between hindlimb digit loss and increases in vertebral number, as well as reduced correlations between limb lengths. Our results support the idea that terrestrial plantigrade locomotion constrains limb evolution and, when lifted, leads to higher rates of trait diversification and shifts in optima and integration. The basic tetrapod body form of most salamanders and the independent losses of terrestrial life stages provide an important framework for understanding the evolutionary and developmental mechanisms behind major shifts in ecological zones as seen among early tetrapods during their transition from water to land. 相似文献
11.
Henry G. Burger 《The Journal of steroid biochemistry and molecular biology》1999,69(1-6):31-35
Menopause is defined as the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. Ovarian primordial follicle numbers decrease with increasing age up to about age 38 following which there is a much steeper decline in the last 12 or so years of reproductive life. At the time of the menopause itself, few follicles remain within the ovary. The recent availability of assays specific for the dimeric inhibins A and B has permitted clarification of the endocrine events leading up to and occurring around the time of final menses. Those women who show clear elevations in serum FSH above age 40, while continuing to cycle regularly have significantly lower inhibin B levels than those whose FSH levels remain in the range seen earlier in reproductive life. Early in the menopause transition, when cycle irregularity is first observed, the initial event is a decline in circulating inhibin B levels in the early follicular phase. In the late perimenopause, levels of estradiol and inhibin A also fall, inhibin B levels remain low and FSH is markedly elevated. The variability of hormone levels in women in their 40s, even in those who are continuing to cycle regularly makes FSH and estradiol unreliable markers of menopausal status. Serum androgen levels appear to fall with age rather than having any clear cut relationship to the menopause transition or menopause. The endocrine changes which occur during the menopausal transition and early postmenopausal period have clinical consequences in terms of symptoms and changes in bone mass. 相似文献
12.
Nomadic behaviour and colony fission in a cooperative spider: life history evolution at the level of the colony? 总被引:1,自引:0,他引:1
LETICIA AVILÉS 《Biological journal of the Linnean Society. Linnean Society of London》2000,70(2):325-339
The concept of colony-level life history evolution is introduced for the cooperative spiders by describing the life cycle and demography of Atbuhna binotata (Araneae: Dictynidae), a species living in groups containing up to several dozen adult females plus their offspring. In a life cycle remarkably similar to that of army ants, the colonies of A binotata were found to reproduce by fission and to alternate nomadic and sedentary phases in tight association with their internal demography. Colonies of other cooperative spiders, on the other hand, remain stationary as they grow for a number of generations before producing propagules that are relatively small subsets of the maternal colony. It is suggested that A. binotata!% peculiar life cycle may have unfolded as a consequence of the two-dimensional architecture of its nests. Expanding two-dimensional nests may fragment more easily than the three-dimensional nests characteristic of other species. A long distance group migration or nomadic phase, described here for the first time for a spider, may have followed as a mechanism to cope with potential disadvantages of fission while selecting for strict synchronization of individual life cycle stages within the nests. It is shown, however, that, as in other cooperative spiders, A. binotatd% sex ratio is also highly female biased. The theoretical implications of biased sex ratios in a species with fissioning colonies are briefly discussed. 相似文献
13.
The hepatitis C virus NS2/3 protease 总被引:1,自引:0,他引:1
The hepatitis C virus NS2/3 protein is a highly hydrophobic protease responsible for the cleavage of the viral polypeptide between non-structural proteins NS2 and NS3. However, many aspects of the NS2/3 protease's role in the viral life cycle and mechanism of action remain unknown. Based on the recently elucidated crystal structure of NS2, NS2/3 has been proposed to function as a cysteine protease despite its lack of sequence homology to proteases of known function. In addition, although shown to be required for HCV genome replication and persistent infection in a chimpanzee, the role of NS2/3 cleavage in the viral life cycle has not yet been fully investigated. However, several recent studies are beginning to clarify possible roles of the cleaved NS2 protein in modulation of host cell gene expression and apoptosis. 相似文献
14.
Synchronous cultures of Chlorella pyrenoidosa have been used in studies of the action of UV-irradiation during different stages in the life cycle on cell division capacity. These experiments show that there is a considerably higher sensitivity to UV-irradiation during the first hours of the life cycle. The variations in photoreactivating capacity of UV-damaged cells during a life cycle have been investigated. The results from these investigations show that the photoreactivating capacity varies and that it is higher in young daughter cells (autospores) and 12–15 hour cells. These variations can be due to variations in the activity of the photoreactivating enzyme during the life cycle. 相似文献
15.
《International journal for parasitology》2022,52(1):65-75
The remodelling of flagella into attachment structures is a common and important event in the trypanosomatid life cycle. Lotmaria passim and Crithidia mellificae can parasitize Apis mellifera, and as a result they might have a significant impact on honeybee health. However, there are details of their life cycle and the mechanisms underlying their pathogenicity in this host that remain unclear. Here we show that both L. passim promastigotes and C. mellificae choanomastigotes differentiate into haptomonad stages covering the ileum and rectum of honeybees. These haptomonad cells remain attached to the host surface via zonular hemidesmosome-like structures, as revealed by transmission electron microscopy. This work describes for the first known time the haptomonad morphotype of these species and their hemidesmosome-like attachments in A. mellifera, a key trait used by other trypanosomatid species to proliferate in the insect host hindgut. 相似文献
16.
The evolution of an annual life cycle in killifish: adaptation to ephemeral aquatic environments through embryonic diapause
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Andrew I. Furness 《Biological reviews of the Cambridge Philosophical Society》2016,91(3):796-812
An annual life cycle is characterized by growth, maturity, and reproduction condensed into a single, short season favourable to development, with production of embryos (seeds, cysts, or eggs) capable of surviving harsh conditions which juveniles or adults cannot tolerate. More typically associated with plants in desert environments, or temperate‐zone insects exposed to freezing winters, the evolution of an annual life cycle in vertebrates is fairly novel. Killifish, small sexually dimorphic fishes in the Order Cyprinodontiformes, have adapted to seasonally ephemeral water bodies across much of Africa and South America through the independent evolution of an annual life history. These annual killifish produce hardy desiccation‐resistant eggs that undergo diapause (developmental arrest) and remain buried in the soil for long periods when fish have perished due to the drying of their habitat. Killifish are found in aquatic habitats that span a continuum from permanent and stable to seasonal and variable, thus providing a useful system in which to piece together the evolutionary history of this life cycle using natural comparative variation. I first review adaptations for life in ephemeral aquatic environments in killifish, with particular emphasis on the evolution of embryonic diapause. I then bring together available evidence from a variety of approaches and provide a scenario for how this annual life cycle evolved. There are a number of features within Aplocheiloidei killifish including their inhabitation of marginal or edge aquatic habitat, their small size and rapid attainment of maturity, and egg properties that make them particularly well suited to the colonization of ephemeral waters. 相似文献
17.
Enrique Meléndez-Hevia Thomas G. Waddell Marta Cascante 《Journal of molecular evolution》1996,43(3):293-303
The evolutionary origin of the Krebs citric acid cycle has been for a long time a model case in the understanding of the origin and evolution of metabolic pathways: How can the emergence of such a complex pathway be explained? A number of speculative studies have been carried out that have reached the conclusion that the Krebs cycle evolved from pathways for amino acid biosynthesis, but many important questions remain open: Why and how did the full pathway emerge from there? Are other alternative routes for the same purpose possible? Are they better or worse? Have they had any opportunity to be developed in cellular metabolism evolution? We have analyzed the Krebs cycle as a problem of chemical design to oxidize acetate yielding reduction equivalents to the respiratory chain to make ATP. Our analysis demonstrates that although there are several different chemical solutions to this problem, the design of this metabolic pathway as it occurs in living cells is the best chemical solution: It has the least possible number of steps and it also has the greatest ATP yielding. Study of the evolutionary possibilities of each one-taking the available material to build new pathways-demonstrates that the emergence of the Krebs cycle has been a typical case of opportunism in molecular evolution. Our analysis proves, therefore, that the role of opportunism in evolution has converted a problem of several possible chemical solutions into asingle-solution problem, with the actual Krebs cycle demonstrated to be the best possible chemical design. Our results also allow us to derive the rules under which metabolic pathways emerged during the origin of life. 相似文献
18.
Yi-Wen Chiu Sangwon Suh Stephan Pfister Stefanie Hellweg Annette Koehler 《The International Journal of Life Cycle Assessment》2012,17(1):16-24
Purpose
Though the development of biofuel has attracted numerous studies for quantifying potential water demand applying life cycle thinking, the impacts of biofuel water consumption still remain unknown. In this study, we aimed to quantify ecological impact associated with corn-based bioethanol water consumption in Minnesota in responding to different refinery expansion scenarios by applying a life cycle impact assessment method. 相似文献19.
During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late stages of the retrovirus life cycle, consisting of virus replication and egress, have been partly unraveled, the early steps remain largely enigmatic. These early steps consist of a long and perilous journey from the cell surface to the nucleus where the proviral DNA integrates into the host genome. Retroviral particles must bind specifically to their target cells, cross the plasma membrane, reverse-transcribe their RNA genome, while uncoating the cores, find their way to the nuclear membrane and penetrate into the nucleus to finally dock and integrate into the cellular genome. Along this journey, retroviruses hijack the cellular machinery, while at the same time counteracting cellular defenses. Elucidating these mechanisms and identifying which cellular factors are exploited by the retroviruses and which hinder their life cycle, will certainly lead to the discovery of new ways to inhibit viral replication and to improve retroviral vectors for gene transfer. Finally, as proven by many examples in the past, progresses in retrovirology will undoubtedly also provide some priceless insights into cell biology. 相似文献
20.
Susana M. Coelho Olivier Godfroy Alok Arun Gildas Le Corguillé Akira F. Peters J. Mark Cock 《Plant signaling & behavior》2011,6(11):1858-1860
The life cycle of an organism is one of its most elemental features, underpinning a broad range of phenomena including developmental processes, reproductive fitness, mode of dispersal and adaptation to the local environment. Life cycle modification may have played an important role during the evolution of several eukaryotic groups, including the terrestrial plants. Brown algae are potentially interesting models to study life cycle evolution because this group exhibits a broad range of different life cycles. Currently, life cycle studies are focused on the emerging brown algal model Ectocarpus. Two life cycle mutants have been described in this species, both of which cause the sporophyte generation to exhibit gametophyte characteristics. The ouroboros mutation is particularly interesting because it induces complete conversion of the sporophyte generation into a functional, gamete-producing gametophyte, a class of mutation that has not been described so far in other systems. Analysis of Ectocarpus life cycle mutants is providing insights into several life-cycle-related processes including parthenogenesis, symmetric/asymmetric initial cell divisions and sex determination. 相似文献