共查询到20条相似文献,搜索用时 15 毫秒
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Ali M. Banaei-Moghaddam Veit Schubert Katrin Kumke Oda Weiβ Sonja Klemme Kiyotaka Nagaki Ji?í Macas Mónica González-Sánchez Victoria Heredia Diana Gómez-Revilla Miriam González-García Juan M. Vega Maria J. Puertas Andreas Houben 《The Plant cell》2012,24(10):4124-4134
B chromosomes (Bs) are supernumerary components of the genome and do not confer any advantages on the organisms that harbor them. The maintenance of Bs in natural populations is possible by their transmission at higher than Mendelian frequencies. Although drive is the key for understanding B chromosomes, the mechanism is largely unknown. We provide direct insights into the cellular mechanism of B chromosome drive in the male gametophyte of rye (Secale cereale). We found that nondisjunction of Bs is accompanied by centromere activity and is likely caused by extended cohesion of the B sister chromatids. The B centromere originated from an A centromere, which accumulated B-specific repeats and rearrangements. Because of unequal spindle formation at the first pollen mitosis, nondisjoined B chromatids preferentially become located toward the generative pole. The failure to resolve pericentromeric cohesion is under the control of the B-specific nondisjunction control region. Hence, a combination of nondisjunction and unequal spindle formation at first pollen mitosis results in the accumulation of Bs in the generative nucleus and therefore ensures their transmission at a higher than expected rate to the next generation. 相似文献
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The Nature of Genetic Recombination near the Third Chromosome Centromere of DROSOPHILA MELANOGASTER
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Previous studies have indicated that recombination near the third chromosome centromere is associated with negative chromosome interference, a phenomenon for which Green (1975) and Sinclair (1975) suggested gene conversion as a possible mechanism. In this report, we demonstrate that negative chromosome interference is still observed when deficiencies or translocation breakpoints are scored as the middle markers in recombination experiments and the rate of recombination is increased by interchromosomal effect. We argue that these chromosomal rearrangement breakpoints are not subject to conversion. Since neither successive premeiotic and meiotic exchanges, nor negative chromatid interference, can by themselves account for the negative chromosome interference, we conclude that a greater than expected frequency of multiple exchanges actually occurs. We further suggest that negative chromosome interference may be characteristic of all chromosomal regions normally showing very little exchange in relation to physical length. 相似文献
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Mitotic Nondisjunction in the Case of Interchanges Involving the B-Type Chromosome in Maize 总被引:8,自引:0,他引:8
Roman H 《Genetics》1947,32(4):391-409
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《Cell cycle (Georgetown, Tex.)》2013,12(10):1232-1234
One of the key differences between mitosis and meiosis is the necessity for exchange between homologous chromosomes. Crossing-over between homologous chromosomes is essential for proper meiotic chromosome segregation in most organisms, serving the purpose of linking chromosomes to their homologous partners until they segregate from one another at anaphase I. In several organisms it has been shown that occasional pairs of chromosomes that have failed to experience exchange segregate with reduced fidelity compared to exchange chromosomes, but do not segregate randomly. Such observations support the notion that there are mechanisms, beyond exchange, that contribute to meiotic segregation fidelity. Recent findings indicate that active centromere pairing is important for proper kinetochore orientation and consequently, segregation of non-exchange chromosomes. Here we discuss the implications of these findings for the behavior of meiotic chromosomes. 相似文献
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Nondisjunction: localization of the controlling site in the maize B chromosome 总被引:4,自引:1,他引:3
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Ward EJ 《Genetics》1973,73(3):387-391
Nondisjunction of the B chromosome in maize has been considered to be controlled by heterochromatin in its long arm. Experiments reported here indicate that the control site actually lies in a short, relatively euchromatic segment distal to the major heterochromatin of the long arm. 相似文献
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Wayne R. Carlson 《Chromosoma》1970,30(3):356-365
Bianchi et al. (1961) found that sectored losses of B-translocation chromosomes occur at a significant rate during early development of the endosperm and sporophyte. The losses were attributed to nondisjunction of the chromomosome, since B type chromosomes are known to undergo nondisjunction at the second pollen mitosis. Sector formation was further analyzed in the present paper, using the translocation, TB-9b. It was found that losses of the B9 chromosome during early endosperm mitoses occur only if the 9B chromosome is present. In addition, sectors are produced in the sporophyte only if the 9B and B9 chromosomes are inherited from the male parent. Both of these findings suggest that nondisjunction is indeed responsible for the B9 losses (see text). However, cytological observation of sectored plants demonstrates that isochromosome formation, rather than nondisjunction, produces most B9 losses in the sporophyte. The conflicting results can be reconciled by assuming that the same basic event, perhaps stickiness of the B9 chromosome, produces nondisjunction at the second pollen mitosis and isochromosome formation in the developing sporophyte. Observation of the isochromosome in pachytene reveals that a heterochromatic region corresponding to the short arm of the normal B9 is missing. The normal B9 chromosome is, therefore, an acrocentric chromosome. 相似文献
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Alberto L. Rosa Sergio D. Haedo Esteban D. Temporini Graciela A. Borioli Mario R. Mautino 《Fungal genetics and biology : FG & B》1997,21(3):315-322
Chromosome translocation breakpoints, RFLP heterozygosity in partial chromosome duplications, and RFLP-marked crossover events have been used as chromosomal landmarks to find the position and orientation of cloned regions flanking centromere I ofNeurospora crassa.Determination of physical:genetic ratios in genomic regions flanking the locimei-3, un-2,andhis-2supports previous evidence indicating that recombinational activity is lower in regions flanking centromere I than in the generalN. crassagenome. The homogeneous distribution of crossover events found in these regions suggests that there is not a gradient of crossover inhibition in the vicinity of centromere I. Thus, a largely extended centromeric effect and/or a general crossover inhibitory effect operating on linkage group I (LGI) could constitute the basis of these abnormal physical:genetic ratios. A DNA element containing about 76% A + T was isolated from the centromeric end of a cloned region on LGIR. The fragment includes a previously undescribed DNA sequence, highly repeated in theNeurosporagenome, which may correspond to centromeric DNA. 相似文献
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玉米B染色体特异RAPD分子标记的染色体定位 相似文献
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Meiotic Nondisjunction and Recombination of Chromosome III and Homologous Fragments in Saccharomyces Cerevisiae 总被引:2,自引:1,他引:1
A yeast strain, in which nondisjunction of chromosome III at the first-meiotic division could be assayed, was constructed. Using chromosome fragmentation plasmids, chromosomal fragments (CFs) were derived in isogenic strains from six sites along chromosome III and one site on chromosome VII. Whereas the presence of the CFs derived from chromosome III increased considerably the meiosis I nondisjunction of that chromosome, the CF derived from chromosome VII had no effect on chromosome III segregation. The effects of the chromosome III-derived fragments were not linearly related to fragment length. Two regions, one of 12 kb in size located at the left end of the chromosome, and the other of 5 kb, located at the center of the right arm, were found to have profound effects on chromosome III nondisjunction. Most disomics arising from meioses in strains containing chromosome III CFs did not contain the CF; thus it appears that the two chromosome III homologs had segregated away from the CF. Among the disomics, recombination between the homologous chromosomes III was lower than expected from the genetic distance, while recombination between one of the chromosomes III and the fragment was frequent. We suggest that there are sites along the chromosome that are more involved than others in the pairing of homologous chromosomes and that the pairing between fragment and homologs involves recombination among these latter elements. 相似文献
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Journey to the Center of the Genome: Complete Sequence of the Rice Chromosome 8 Centromere 总被引:1,自引:0,他引:1
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Nancy A. Eckardt 《The Plant cell》2004,16(4):789-791
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Centromere Binding and a Conserved Role in Chromosome Stability for SUMO-Dependent Ubiquitin Ligases
Loes A. L. van de Pasch Antony J. Miles Wilco Nijenhuis Nathalie A. C. H. Brabers Dik van Leenen Philip Lijnzaad Markus K. Brown Jimmy Ouellet Yves Barral Geert J. P. L. Kops Frank C. P. Holstege 《PloS one》2013,8(6)
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Most Uv-Induced Reciprocal Translocations in SORDARIA MACROSPORA Occur in or near Centromere Regions
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In fungi, translocations can be identified and classified by the patterns of ascospore abortion in asci from crosses of rearrangement x normal sequence. Previous studies of UV-induced rearrangements in Sordaria macrospora revealed that a major class (called type III) appeared to be reciprocal translocations that were anomalous in producing an unexpected class of asci with four aborted ascospores in bbbbaaaa linear sequence (b = black; a = abortive). The present study shows that the anomalous type III rearrangements are, in fact, reciprocal translocations having both breakpoints within or adjacent to centromeres and that bbbbaaaa asci result from 3:1 disjunction from the translocation quadrivalent.-Electron microscopic observations of synaptonemal complexes enable centromeres to be visualized. Lengths of synaptonemal complexes lateral elements in translocation quadrivalents accurately reflect chromosome arm lengths, enabling breakpoints to be located reliably in centromere regions. All genetic data are consistent with the behavior expected of translocations with breakpoints at centromeres.-Two-thirds of the UV-induced reciprocal translocations are of this type. Certain centromere regions are involved preferentially. Among 73 type-III translocations, there were but 13 of the 21 possible chromosome combinations and 20 of the 42 possible combinations of chromosome arms. 相似文献