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Børud B Hoang T Bakke M Jacob AL Lund J Mellgren G 《Molecular endocrinology (Baltimore, Md.)》2002,16(4):757-773
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Teyssier C Ou CY Khetchoumian K Losson R Stallcup MR 《Molecular endocrinology (Baltimore, Md.)》2006,20(6):1276-1286
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Arai S Ogawa K Yamachika S Nishihara T Nishikawa J 《Biochimica et biophysica acta》2001,1518(1-2):7-18
The factors SRC-1, TIF2 and ACTR were identified as interacting with nuclear receptors in a highly ligand-dependent manner. Because the molecular mass of each of these factors is approximately 160 kDa, they are collectively termed p160 coactivators. So far, p160 coactivators have been cloned from human, mouse and Xenopus. We report here the cloning of the chicken homologues of p160 coactivator members. As in human and mouse, chicken has three p160 coactivators. Each gene encodes an approximately 160 kDa protein which exhibits 70-80% amino acid sequence identity to human and mouse p160 coactivators. Chicken p160 coactivators also have the property of interacting with several liganded nuclear receptors. Moreover, we describe an imperfect LXXLL sequence, termed NR box 4, which is located downstream of NR box 3 and conserved between evolutionarily diverse species. The loss of NR box 4 results in a decrease of interaction with the nuclear receptor, which indicates that NR box 4 is required for efficient interaction. 相似文献